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SIAIS Hosts 2017 BioForum

Author£ºSIAIS
Date£º30 November 2017


SIAIS hosted a successful 2017 ShanghaiTech-SIAIS BioForum at ShanghaiTech¡¯s brand-new conference center from November 13th to 16th.Read more



3rd ShanghaiTech-SIAIS BioForum a Success

Author£ºSIAIS
Date£º13 November 2016


Shanghai Institute for Advanced Immunochemical Studies (SIAIS) in collaboration with Amgen Biopharmaceutical (Shanghai) Co., Ltd successfully held the 2016 Bio-Forum in Pudongfrom November 7th to 10th.Twenty scientists from the world¡¯s top universities and research institutions, including Nobel laureates and academicians from Chinese Academy of Science were invited to attend as distinguished speakers and more than 300 researchers and representatives of biological medicine industry attended this year¡¯s Bio-Forum.Read more



ShanghaiTech-SIAIS BioForum 2015 Convened

Author£ºSIAIS
Date£º13 November 2015


Shanghai Institute for Advanced Immunochemical Studies (SIAIS) held the 2015 Bioforum in collaboration with Amgen Biopharmaceutical (Shanghai) Co., Ltd from November 10th-12th. Vice President and Provost Yin Jie, Deputy Director of Pudong Science and Technology Commission Gu Bing and Head of hi-tech development department of Pudong Science and Technology Commission Kong Lingyi attended the forum.Read more



ShanghaiTech-SIAIS Bioforum 2014 Held in Shanghai

Author£ºSIAIS
Date£º23 November 2014


From November 17th to 20th, 2014 ShanghaiTech-SIAIS Bioforum was held by SIAIS in partnership with Amgen, which attracted more than 300 representatives from industry and academia around the worldRead more



The SIAIS Scientific Governance Board Held its Annual Meeting

Author£ºSIAIS
Date£º23 November 2014


On November 17th, the SIAIS Scientific Governance Board Annual Meeting 2014 was held in ShanghaiTech University withboard members including Mianheng Jiang, President of ShanghaiTech and Shanghai Branch of Chinese Academy of Sciences(CAS).Read more

 
Research


ShanghaiTech Researchers Discover a New Electron Transfer Mechanism from a Mycobacterial Respiratory Supercomplex

Author£ºSIAIS Date£º2018-10-30


On October 25, 2018, the Science published online the research article from the team led by ShanghaiTech Distinguished Professor-in-Residence Rao Zihe with the title ¡°An electron transfer path connects subunits of a mycobacterial respiratory supercomplex¡±.   
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Lab of stem cell biology reveals the mechanism of Wnt/¦Â-catenin signaling pathway activation in triple negative breast cancer

Author£ºSIAIS Date£º2018-10-12


Recently, stem cell biology group has revealed a new mechanism of Wnt/¦Â-catenin signaling pathway activation in triple-negative breast cancer. The research was published in Journal of Molecular Cell Biology as ¡°Cover story¡± with the title of MiR-221/222 activate the Wnt/beta-catenin signaling to promote triple negative breast cancer.
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SIAIS Laboratory of ADC Chemistry Publish a Volume for Zinc Finger Proteins on Methods in Molecular Biology

Author£ºSIAIS Date£º2018-10-10


Research Associate Professor Jia Liu from Prof. Biao Jiang¡¯s Laboratory of ADC Chemistry in SIAIS has completed editing the 1867 volume of Methods in Molecular Biology (MiMB) with a volume title of Zinc Finger Proteins: Methods and Protocols. This volume of MiMB has been available from Springer, Amazon and other booksellers.  
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Laboratory of T Cell Engineering at SIAIS and collaborators report new technology for genome editing in CAR T cell

Author£ºSIAIS Date£º2018-10-10


Recently, Research Associate Professor Xuekai Zhu from T Cell Engineering Laboratory at SIAIS, and Professor Xingxu Huang from SLST have developed a new technology for the preparation of genome-edited chimeric antigen receptor (CAR) T cells based on non-viral vectors. The researchers used the CRISPR/Cas9 system to achieve efficient knockout of the PD-1 gene in human T cells, while stably integrating and expressing CD133-specific CAR via the transposon system. The study was published in the journal Human Gene Therapy titled with Nucleofection with Plasmid DNA for CRISPR/Cas9-Mediated Inactivation of Programmed Cell Death Protein 1 in CD133-Specific CAR T Cells.
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From the Phenotypic Screening group of Guang Yang, a hope for the treatment of a rare disease

Author£º Date£º2017-9-21


Keracthitis ¨C Ichtyosis ¨C Deafness (KID) Syndrome, is a rare genetic disease, caused by mutations of GJB2 gene, which produce severe phenotypes in skin and inner ear. Connexin 26 (Cx26) proteins, encoded by GJB2, olygomerize to form gap junction channels, which allow direct communication between two cells, or connexin hemichannels, which function as regular membrane channels. Connexin hemichannels are normally close in physiological condition, but can open in response to a variety of electrochemical stimuli. Several point mutations of Cx26 that lead to KID syndrome have been shown to produce hemichannels which do not correctly close in physiological conditions (hyperactive hemichannels).
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Events


Mirror Bisulfite Sequencing: A Method for Single-Base Resolution of Hydroxymethylcytosine


Author£ºDr. Xueguang Sun
Date£º3:00 pm, Dec. 14th(Friday), 2018

While the role of 5-methylcytosine has been well studied, the biological role of 5-hydroxymethylcytosine still remains unclear due to the limited...  Read more


First SIAIS Happy Friday Seminar Successfully Held


Author£ºDr. Liu Jia
Date£º3:30 pm, Dec. 7th(Friday), 2018

December 7th Friday, Dr. Jia Liu from SIAIS presented in SIAIS Happy Friday Seminar a talk with a title ¡°CRISPR Babies, CCR5 Knockout and Beyond-Does the X-Man World Finally Come?¡±.  Read more


TGF-¦Â Signal Transduction in Human Diseases


Author£ºProf. Peter ten Dijke
Date£º10:00 am, Dec. 6(Thu), 2018

TGF-¦Â family members, which includes TGF-¦Âs, activins and BMPs, are pleiotropic cytokines that elicit cell type-specific effects in a highly context-dependent manner... Read more


Welcome to the DNA Zoo


Author£ºDr. Erez Lieberman Aiden
Date£º10:30-11:30, Dec. 3(Monday), 2018

A central challenge in creating high-quality genomes is cost. Although the cost of sequencing short intervals of DNA has plummeted...  Read more


Therapeutic antibody development with synthetic antibody technology


Author£ºDr. Xincheng Hou
Date£º3:30 pm, Nov. 23(Friday), 2018

Synthetic antibody technology has proven to generate high specific and functional antibodies against a broad range of molecules.  Read more


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