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SIAIS Laboratory of ADC Chemistry Publish a Volume for Zinc Finger Proteins on Methods in Molecular Biology

Research Associate Professor Jia Liu from Prof. Biao Jiangs Laboratory of ADC Chemistry in SIAIS has completed editing the 1867 volume of Methods in Molecular Biology (MiMB) with a volume title of Zinc Finger Proteins: Methods and Protocols. This volume of MiMB has been available from Springer, Amazon and other booksellers.

The MiMB book series was founded by the series editor John Walker in 1983. MiMB provides methods and protocols in molecular biology and is well known for providing step-by-step experimental procedures. The first MiMB volume specialized on zinc finger proteins (ZFPs) was edited by Prof. Joel Mackay and Prof. David Segal in 2010. Recent years we have seen notable progress on both the basic research and therapeutic applications of ZFPs. The new MiMB volume on ZFPs covers the methods and protocols of cutting-edge ZFPs technologies, providing thorough guidance for researchers in the ZFPs field.

ZFPs are the most abundant transcription factors in eukaryotes, playing important roles in a variety of biological functions such as DNA methylation, DNA transcription, cell cycle, cell division, tumorigenesis and others. ZFPs bind zinc ions via cysteine and histidine residues and can be categorized into C2H2C4 and CCHC type ZFPs according to different means of chelating zinc ions. Decades studies have deciphered the DNA recognition of ZFPs. Artificial ZFPs along with the newly emerged TALE and CRISPR systems have been widely used in gene regulation and genome engineering fields. Recent studies also proved that zinc finger nucleases, which contains ZFPs as the DNA binding domain, are safe in human trials, shedding the light on the potential of ZFPs for biomedical applications.

    This MiMB volume of ZFPs contains three parts consisting 19 chapters, covering the topics on the basic biological functions, design of artificial ZFPs, evaluation of the cytotoxicity, delivery methods and others. This volume of MiMB will facilitate both the basic ZFP research and development of next-generation ZFPs therapeutics.


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