饶子和 博士

发布者:冯明静发布时间:2019-11-14浏览次数:195

  饶子和 博士

所在学院 免疫化学研究所

              生命科学与技术学院

研究方向 蛋白质机器与新药

联系方式 raozh@@shanghaitech.edu.cn

              raozh@@mail.tsinghua.edu.cn

备注 中国科学院院士


主要研究内容

饶子和教授主要利用X-ray和Cro-EM等现代生物物理技术手段,研究人类新发、再发传染病病原体的蛋白质机器的结构与功能,以及基于结构的创新药物开发。他的研究重点关注结核分枝杆菌的关键药物靶点,包括细胞壁合成、呼吸链和转录、复制相关的超级分子机器。同时,饶子和教授长期从事SARS病毒、流感病毒、艾滋病病毒、肝炎病毒、疱疹病毒、小RNA病毒和黄病毒等重要病原体在宿主入侵、复制和组装过程中起关键作用的分子机器的研究,并针对性的开发新型抗病毒药物和疫苗。                                     


代表性论文

  1. Wang Q*, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P*, Rao Z* (2020). Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell. doi: https://doi.org/10.1016/j.cell.2020.05.034.   

  2. Zhenming Jin#, Yao Zhao#, Yuan Sun#, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W. Guddat, Gengfu Xiao, Leike Zhang*, Haitao Yang* & Zihe Rao. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol (2020). https://doi.org/10.1038/s41594-020-0440-6

  3.  Yan Gao#, Liming Yan#, Yucen Huang#, Fengjiang Liu#, Yao Zhao, Lin Cao, Tao Wang, Qianqian Sun, Zhenhua Ming, Lianqi Zhang, Ji Ge, Litao Zheng, Ying Zhang, Haofeng Wang, Yan Zhu, Chen Zhu, Tianyu Hu, Tian Hua, Bing Zhang, Xiuna Yang, Jun Li, Haitao Yang, Zhijie Liu, Wenqing Xu, Luke W. Guddat, Quan Wang*, Zhiyong Lou*, Zihe Rao*. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science  10 Apr 2020:DOI: 10.1126/science.abb7498

  4. Zhenming Jin#, Xiaoyu Du#, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W. Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zhengli Shi, Hualiang Jiang, Zihe Rao, Haitao Yang. Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature (2020) Published: 09 April 2020

  5. Wang L, Wu J, Li J, Yang H, Tang T, Liang H, Zuo M, Wang J, Liu H, Liu F, Chen J, Liu Z, Wang Y, Peng C, Wu X, Zheng R, Huang X, Ran Y, Rao Z, Ge B. (2020)Host-mediated ubiquitination of a mycobacterial protein suppresses immunity. Nature. 2020 Jan; 577(7792):682-688. doi: 10.1038/s41586-019-1915-7. Epub 2020 Jan 15.

  6. Wang N#, Zhao D#, Wang J#, Zhang Y#, Wang M, Gao Y, Li F, Wang J, Bu Z*, Rao Z*, Wang X*., Architecture of African swine fever virus and implications for viral assembly. Science. 2019 Nov 1;366(6465):640-644. doi: 10.1126/science.aaz1439. ISSN: 0033-3131.

  7. Wang S#, Zhou K, Yang X, Zhang B, Zhao Y, Xiao Y, Yang X, Yang H, Guddat LW, Li J*, Rao Z*. Structural insights into substrate recognition by the type VII secretion system. Protein & Cell. 2019 Nov 23. doi: 10.1007/s13238-019-00671-z. ISSN:1674-8018.

  8. Wang M, Guo X, Yang X, Zhang B, Ren J, Liu A, Ran Y, Yan B, Chen F, Guddat LW, Hu J, Li J and Rao Z., Mycobacterial dynamin-like protein IniA mediates membrane fission. Nat Commun. 2019 Aug 29;10(1):3906. doi: 10.1038/s41467-019-11860-z.ISSN:2041-1723.

  9. Zhang B, Li J*, Yang X, Wu L, Zhang J, Yang Y, Zhao Y, Zhang L, Yang X, Yang X, Cheng X, Liu Z, Jiang B, Jiang H, Guddat LW, Yang H*, Rao Z*., Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24;176(3):636-648.e13. ISSN:0092-8674.

  10. Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F*, Wang Q*, Rao Z*., An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science. 2018 Oct 25. pii: eaat8923. doi: 10.1126/science.aat8923

  11. Yuan S, Wang J, Zhu D, Wang N, Gao Q, Chen W, Tang H, Wang J, Zhang X, Liu H*, Rao Z* and Wang X*. Cryo-EM structure of a Herpesvirus capsid at 3.1 ÅScience. 2018 Apr 6;360(6384).

  12. Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z*, Lou Z*, Xie D*. DWARF14 is a non-canonical hormone receptor for strigolactone. Nature. 2016 Aug 1;536(7617):469-473

  13. Wang X, Ren J, Gao Q, Hu Z, Sun Y, Li X, Rowlands DJ, Yin W, Wang J*, Stuart DI*, Rao Z* & Fry EE*. The structure of hepatitis A virus and the origins of picornaviruses. Nature. 2015 Jan 1;517(7532):85-8.

  14. Yuan P, Bartlam M, Lou Z, Chen S, Zhou J, He X, Lv Z, Ge R, Li X, Deng T, Fodor E, Rao Z* & Liu Y*.  Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature, 2009 ;458(7240) :909-13

  15. He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A., Zeng Z, Ge R, Rao Z* & Liu YF*. Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature, 2008 ;454(7208) :1123-6

  16. Sun F, Huo X, Zhai YJ, Wang AJ, Xu JX, Su D, Bartlam M Rao Z*. Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex Ⅱ. Cell, 2005; 121: 1043-1057

  17. Rao Z, Belyaev A, Fry E, Jones I, Roy P & Stuart D. Crystal structure of SIV matrix antigen and implications for virus assembly. Nature,1995 ;378(6558):743-747

  18. Rao Z, Handford P, Mayhew M, Knott V, Brownlee G & Stuart D. The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions. Cell, 1995;82(1):131-141