药物发现平台科学主任 教授 研究员 课题组长 免疫化学研究所执行所长 所在学院 免疫化学研究所 生命科学与技术学院 研究方向 病原微生物与宿主相互作用、药物开发 荣誉称号 国家级重大人才计划特聘教授、国家973计划首席科学家（青年） 联系方式 yanght@@shanghaitech.edu.cn 
个人简介
1997—2001，四川大学，学士 2001—2006，清华大学，博士 2006—2011，耶鲁大学，博士后 2011—2013，耶鲁大学，Associate Research Scientist 2013—2017，天津大学，教授、副院长 2013—至今，天津国际生物医药联合研究院，研究员、抗感染药物研发中心主任 2018—2022/11，上海科技大学生命科学与技术学院、免疫化学研究所，研究员、副教授(TENURE-TRACK) 2022/11—至今，上海科技大学生命科学与技术学院、免疫化学研究所，教授(TENURE-TRACK) 2020—2021，上海科技大学免疫化学研究所，副所长 2021—至今，上海科技大学免疫化学研究所，执行所长
主要研究内容
病毒和细菌都是非常重要的病原体，它们可引发多种严重传染病。就病毒而言，有史以来关于病毒性疾病的记载最早可追溯至5700年前，在古埃及的象形文字中对瘫痪的小儿麻痹症患者的描述。在现代社会中，新冠肺炎、“非典”、艾滋病、寨卡综合征和流感等一系列由病毒引发的重大传染病严重危害人类健康，并产生一系列经济问题和社会问题。在细菌方面，结核分枝杆菌是细菌类病原体的典型代表。全世界约有四分之一的人口被结核杆菌感染，而因结核病致死的人数甚至已超过了艾滋病。
研究组长期从事上述重要病原体引发的重大疾病的研究，并针对性的开展全新药物开发工作。主要涉及的研究方向包括：1、重要病原体的关键药物靶点的结构和功能研究；2、病原体入侵宿主过程中二者之间的精确相互作用和分子机制，特别关注宿主免疫系统与病原体之间“抑制与拮抗”的复杂斗争过程；3、针对关键药物靶点开展合理药物设计、先导药物的高通量筛选以及临床前评价。
研究成果展示 杨海涛教授担任了国家重点研发计划总体专家组专家、国家“重大新药创制”科技重大专项评审专家、法国国家科研署基金外审专家、波兰国家科学基金外审专家、香港特区政府研究资助局评审专家、中国博士后科学基金特别资助专项评审专家、教育部全国博士学位论文抽检评议专家、国家重点基础研究发展计划（973计划）青年项目首席科学家；担任了Nature、The Lancet Infectious Diseases、Nature Chemical Biology、Nature Communications、Science Advances、Angewandte Chemie、Chemical Science、Journal of Medicinal Chemistry、ACS Catalysis、The Lancet's EBioMedicine和Journal of Antimicrobial Chemotherapy等十余种国际知名杂志的审稿人；担任了中国期刊Cell Research、Protein & Cell、Science Bulletin和Journal of Molecular Cell Biology的审稿人。获得了中国产学研合作促进奖、中国侨界贡献奖、科学中国人年度人物、谈家桢生命科学创新奖、树兰青年医学奖、Promega Award for Biochemistry和药明康德生命化学杰出成就奖等奖项。近期研究成果包括： 1、在结核杆菌关键药物靶点的结构和药物发现的研究中取得进展，论文发表于Cell、Science等杂志，并入选2019年度“中国高校十大科技进展”和2019年度“中国生命科学十大进展”。 2、在新型冠状病毒关键药物靶点的结构和药物开发的研究中取得进展，相关研究论文先后在Nature、Science（封面论文）、Cell和Nature Structural & Molecular Biology等杂志发表，并入选2020年度富林沃斯（Falling Walls）生命科学领域十项进展、2020年度“中国生命科学十大进展”。除此之外，相关研究亦与我国其他抗疫成果一起集体入选“2020年度中国科学十大进展”。
奖励
1. ，2020年度中国生命科学十大进展 2. ，药明康德生命化学杰出成就奖 3. ，2020年度富林沃斯（Falling Walls）生命科学领域十项年度进展 4. ，谈家桢生命科学创新奖 5. ，2019年度“中国高校十大科技进展” 6. ，2019年度“中国生命科学十大进展” 7. ，树兰青年医学奖 8. ，普洛麦格生物化学奖(Promega Award for Biochemistry) 9. ，中国侨界贡献奖 10. ，中国产学研合作促进奖 11. ，科学中国人年度人物
代表性论文（*第一作者，#通讯作者） Yao Zhao#*; Yan Zhu*; Xiang Liu*; Zhenming Jin; Yinkai Duan; Qi Zhang; Chengyao Wu; Lu Feng; Xiaoyu Du; Jinyi Zhao; Maolin Shao; Bing Zhang; Xiuna Yang; Lijie Wu; Xiaoyun Ji; Luke W. Guddat; Kailin Yang; Zihe Rao#; Haitao Yang#.Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 05 Apr 2022. 119(16):e2117142119.
Haofeng Wang*; Yunjie Xiao*; Xia Chen*; Mengwen Zhang; Guangxin Sun; Feng Wang; Lin Wang; Hanxiao Zhang; Xiaoyu Zhang; Xin Yang; Wenling Li; Cheng Chen; Wei Shen; Dan Su; Fang Bai; Jinhai Huang; Sheng Ye; Lei Zhang; Xiaoyun Ji; Wei Wang#; Zefang Wang#; Mark Hochstrasser#; Haitao Yang#.Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue.NATURE COMMUNICATIONS. 25 Mar 2022. 13(1):1608.
Hangtian Guo*, Yan Gao, Tinghan Li, Tingting Li, Yuchi Lu, Le Zheng, Yue Liu, Tingting Yang, Feiyang Luo, Shuyi Song, Wei Wang, Xiuna Yang, Henry C. Nguyen, Hongkai Zhang, Ailong Huang#, Aishun Jin#, Haitao Yang#, Zihe Rao#, Xiaoyun Ji#, Structures of Omicron Spike complexes and implications for neutralizing antibody development, Cell Reports, 15 April 2022, 110770.
Lu Lu*; Su Shan; Yang Haitao#; Jiang Shibo#.Antivirals with common targets against highly pathogenic viruses.CELL. 18 Mar 2021. 184(6):1604-1620.
Haitao Yang#*; Zihe Rao#.Structural biology of SARS-CoV-2 and implications for therapeutic development.NATURE REVIEWS MICROBIOLOGY. 17 Sep 2021.
Yunjie Xiao*; Hongli Chen*; Haofeng Wang*; Mengwen Zhang*; Xia Chen; Jason M. Berk; Lilin Zhang; Yi Wei; Wenling Li; Wen Cui; Fenghua Wang; Qianfan Wang; Can Cui; Ting Li; Cheng Chen; Sheng Ye; Lei Zhang; Xiaoyun Ji; Jinhai Huang; Wei Wang#; Zefang Wang#; Mark Hochstrasser#; Haitao Yang#.Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021. 118(41).
Cui,Wen*; Braun,Elisabeth*; Wang,Wei*; Tang,Jinhong*; Zheng,Yanyan*; Slater,Benjamin; Li,Na; Chen,Cheng; Liu,Qingxiang; Wang,Bin; Li,Xiu; Duan,Yinkai; Xiao,Yunjie; Ti,Rujiao; Hotter,Dominik; Ji,Xiaoyun; Zhang,Lei; Cui,Jun; Xiong,Yong; Sauter,Daniel#; Wang,Zefang#; Kirchhoff,Frank#; Yang,Haitao#.Structural basis for GTP-induced dimerization and antiviral functioin of guanylate-binding proteins.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 13 Apr 2021. 118(15).
Li Tingting*; Han Xiaojian*; Gu Chenjian*; Guo Hangtian*; Zhang Huajun; Wang Yingming; Hu Chao; Wang Kai; Liu Fengjiang; Luo Feiyang; Zhang Yanan; Hu Jie; Wang Wang; Li Shenglong; Hao Yanan; Shen Meiying; Huang Jingjing; Long Yingyi; Song Shuyi; Wu Ruixin; Mu Song; Chen Qian; Gao Fengxia; Wang Jianwei; Long Shunhua; Li Luo; Wu Yang; Gao Yan; Xu Wei; Cai Xia; Qu Di; Zhang Zherui; Zhang Hongqing; Li Na; Gao Qingzhu; Zhang Guiji; He Changlong; Wang Wei; Ji Xiaoyun; Tang Ni; Yuan Zhenghong; Xie Youhua#; Yang Haitao#; Zhang Bo#; Huang Ailong#; Jin Aishun#.Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.NATURE COMMUNICATIONS. 02 Nov 2021. 12(1):6304.
Amporndanai, Kangsa*; Meng, Xiaoli; Shang, Weijuan; Jin, Zhenming; Rogers, Michael; Zhao, Yao; Rao, Zihe; Liu, Zhi-Jie; Yang, Haitao#; Zhang, Leike#; O'Neill, Paul M#; Hasnain, S. Samar#.Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.NATURE COMMUNICATIONS. 24 May 2021. 12(1).
Jin, Zhenming*; Du, Xiaoyu*; Xu, Yechun*; Deng, Yongqiang*; Liu, Meiqin*; Zhao, Yao; Zhang, Bing; Li, Xiaofeng; Zhang, Leike; Peng, Chao; Duan, Yinkai; Yu, Jing; Wang, Lin; Yang, Kailin; Liu, Fengjiang; Jiang, Rendi; Yang, Xinglou; You, Tian; Liu, Xiaoce; Yang, Xiuna; Bai, Fang; Liu, Hong; Liu, Xiang; Guddat, Luke W.; Xu, Wenqing; Xiao, Gengfu; Qin, Chengfeng; Shi, Zhengli; Jiang, Hualiang#; Rao, Zihe#; Yang, Haitao#.Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors.NATURE. 09 Apr 2020. 582(7811):289–293.
Dai, Wenhao*; Zhang, Bing*; Jiang, Xia-Ming*; Su, Haixia*; Li, Jian; Zhao, Yao; Xie, Xiong; Jin, Zhenming; Peng, Jingjing; Liu, Fengjiang; Li, Chunpu; Li, You; Bai, Fang; Wang, Haofeng; Cheng, Xi; Cen, Xiaobo; Hu, Shulei; Yang, Xiuna; Wang, Jiang; Liu, Xiang; Xiao, Gengfu; Jiang, Hualiang; Rao, Zihe; Zhang, Lei-Ke#; Xu, Yechun#; Yang, Haitao#; Liu, Hong#.Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.SCIENCE. 19 Jun 2020. 368(6497):1331-1335.
Jin, Zhenming*; Zhao, Yao*; Sun, Yuan*; Zhang, Bing; Wang, Haofeng; Wu, Yan; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Du, Xiaoyu; Duan, Yinkai; Yu, Jing; Yang, Xiaobao; Yang, Xiuna; Yang, Kailin; Liu, Xiang; Guddat, Luke W.; Xiao, Gengfu; Zhang, Leike#; Yang, Haitao#; Rao, Zihe.Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.NATURE STRUCTURAL & MOLECULAR BIOLOGY. 07 May 2020. 27(6):529-532.
Wang, Quan#*; Wu, Jiqin*; Wang, Haofeng*; Gao, Yan*; Liu, Qiaojie*; Mu, An; Ji, Wenxin; Yan, Liming; Zhu, Yan; Zhu, Chen; Fang, Xiang; Yang, Xiaobao; Huang, Yucen; Gao, Hailong; Liu, Fengjiang; Ge, Ji; Sun, Qianqian; Yang, Xiuna; Xu, Wenqing; Liu, Zhijie; Yang, Haitao; Lou, Zhiyong; Jiang, Biao; Guddat, Luke W.; Gong, Peng#; Rao, Zihe#.Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.CELL. 23 Jul 2020. 182(2):417.
Gao, Yan*; Yan, Liming*; Huang, Yucen*; Liu, Fengjiang*; Zhao, Yao; Cao, Lin; Wang, Tao; Sun, Qianqian; Ming, Zhenhua; Zhang, Lianqi; Ge, Ji; Zheng, Litao; Zhang, Ying; Wang, Haofeng; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Hua, Tian; Zhang, Bing; Yang, Xiuna; Li, Jun; Yang, Haitao; Liu, Zhijie; Xu, Wenqing; Guddat, Luke W.; Wang, Quan#; Lou, Zhiyong#; Rao, Zihe#.Structure of the RNA-dependent RNA polymerase from COVID-19 virus.SCIENCE. 15 May 2020. 368(6492):779-+.
Zhang, Lu*; Zhao, Yao*; Gao, Yan; Wu, Lijie; Gao, Ruogu; Zhang, Qi; Wang, Yinan; Wu, Chengyao; Wu, Fangyu; Gurcha, Sudagar S.; Veerapen, Natacha; Batt, Sarah M.; Zhao, Wei; Qin, Ling; Yang, Xiuna; Wang, Manfu; Zhu, Yan; Zhang, Bing; Bi, Lijun; Zhang, Xian'en; Yang, Haitao; Guddat, Luke W.; Xu, Wenqing; Wang, Quan#; Li, Jun#; Besra, Gurdyal S.#; Rao, Zihe#.Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.SCIENCE. 12 Jun 2020. 368(6496):1211.
Zhang, Bing*; Li, Jun#*; Yang, Xiaolin; Wu, Lijie; Zhang, Jia; Yang, Yang; Zhao, Yao; Zhang, Lu; Yang, Xiuna; Yang, Xiaobao; Cheng, Xi; Liu, Zhijie; Jiang, Biao; Jiang, Hualiang; Guddat, Luke W.; Yang, Haitao#; Rao, Zihe#.Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.CELL. 24 Jan 2019. 176(3):636-+.
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