Peixiang Ma, Ph.D.


  Peixiang Ma, Ph.D.

Research Assistant Professor

B.Sc./ M.Sc. Biochemical Engineering, Beijing Institute of Technology, China 2007

Ph.D., Biology, Department of Physical Biology, Heinrich Heine Universit t Düsseldorf, Germany, 2010 (Helmholtz-DAAD Fellowship)

Postdoc, Institute of Complex Systems-6 (Strukturbiochemie), Forschungzentrum Jülich, Germany. 2011 (Helmholtz Research Fellowship)

Postdoc, Research Engineer, Institut de Biologie Structurale (IBS), France. 2012-2014

Scientist, Institute of Complex Systems-6 (Strukturbiochemie), Forschungzentrum Jülich, Germany. 2014

Research Interest:

1.    Synthetic biology for functional protein ( e.g. antibody, toxin) selection
2.    DNA encoding library for functional small molecule selection
3.    Protein engineering.

Representative publications:

11. Wang W#, Ma P#, Krause H, Zhang Y, Dong H, Willbold D, Andreas Offenhaeusser A, Gu Z, A Magnetic Nanoparticles Relaxation Sensor for Protein-Protein Interaction Detection at Ultra-low Magnetic Field, Biosens Bioelectron. 2016 15(80):661-5. (#contributed equally)

10. Ma P#, Xue Y#, Coquelle N, Haller JD, Yuwen T, Ayala I, Mikhailovskii O, Willbold D, Colletier JP, Skrynnikov NR, Schanda P. Observing the overall rocking motion of a protein in a crystal. (2015) Nat Commun. 5;6:8361. (#contributed equally)

9. Ma P, Schillinger O, Schwarten M, Lecher J, Hartmann R, Stoldt M, Mohrlüder J, Olubiyi O, Strodel B, Willbold D, Weiergräber OH.(2015) Conformational Polymorphism in Autophagy-Related Protein GATE-16. Biochemistry. 8;54(35):5469-79.

8. Sólyom Z, Ma P, Schwarten M, Bosco M, Polidori A, Durand G, Willbold D, Brutscher B. The Disordered Region of the HCV Protein NS5A: Conformational Dynamics, SH3 Binding, and Phosphorylation. (2015) Biophys J. 6;109(7):1483-96.
7. Ma P, Haller JD, Zajakala J, Macek P, Sivertsen A, Willbold D, Boisbouvier J,  Schanda P.  Probing Transient Conformational States of Proteins by Solid-State R1rho Relaxation-Dispersion NMR Spectroscopy.(2014) Angew Chem Int Ed Engl. 22;53(17):4312-7. VIP (very important paper)

6. Ma P#, Schwarten M#, Schneider L, Boeske A, Henke N, Lisak D, Weber S, Mohrlüder J, Stoldt M, Strodel B, Methner A, Hoffmann S, Weiergräber OH, Willbold D. (2013) Interaction of Bcl-2 with the Autophagy-Related Protein GABARAP -- Biophysical Characterization and Functional Implications. J Biol Chem. 288(52):37204-15.  (#contributed equally)

5. Wang W, Dong H, Pacheco V, Willbold D, Zhang Y, Hartmann R, E.Weirich T, Ma P, Krause H-J, Gu Z. (2011) Relaxation behavior study of Ultra-small superparamagnetic iron oxide nanoparticles at Ultra-Low and Ultra-high Magnetic fields. J. Phys. Chem. B. 115 (49): 14789–14793

4. Ma P, Mohrlüder J, Schwarten M, Stoldt M, Singh SK, Hartmann R, Pacheco V, Willbold D. (2010) Preparation of a functional GABARAP-lipid conjugate in nanodiscs and its investigation by solution NMR spectroscopy. Chembiochem. 11(14):1967-70.

3. Pacheco V, Ma P, Thielmann Y, Hartmann R, Weiergräber OH, Mohrlüder J, Willbold D. (2010) Assessment of GABARAP self-association by its diffusion properties. J Biomol NMR. 48(1):49-58.

2. Schwarten M, Mohrlüder J, Ma P, Stoldt M, Thielmann Y, Stangler T, Hersch N, Hoffmann B, Merkel R, Willbold D. (2009) Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy. Autophagy. 5(5):690-8.

1. Thielmann Y, Weiergräber OH, Ma P, Schwarten M, Mohrlüder J, Willbold D. (2009) Comparative modeling of human NSF reveals a possible binding mode of GABARAP and GATE-16. Proteins. 77(3):637-46.