Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
School of Life Science and Technology, ShanghaiTech University
Professor of Cell Biology, of Genetics, and of Ob-Gyn
Director, Yale Stem Cell Center
Yale University School of Medicine
Phone: (203) 785-6239
Fax: (203) 785-430z
Laboratory: Lab of Stem Cell Biology
Dr. Lin received his BS degree from Fudan University (1982), and his Ph.D. degree from Cornell University (1990). Following his postdoctoral research at the Carnegie Institution of Washington, he joined the faculty of Duke University Medical School in 1994, where he rose to the rank of Full Professor. He founded and directed the Duke Stem Cell Research Program (2005-2006), and moved to Yale in 2006 to establish and direct the Yale Stem Cell Center.
Dr. Lin’s work is focused on the self-renewing mechanism of stem cells, using Drosophila germline stem cells, mouse germline and embryonic stem cells, human embryonic stem cells, and Hydra stem cells as models. He also studies germline development and stem cell-related cancers.
Dr. Lin has made key contributions to the demonstration of stem cell asymmetric division, the proof of the stem cell niche theory, the discovery of the Argonuate/PIWI gene family and their essential function in stem cell self-renewal and germline development, as well as the discovery of a novel class of non-coding small RNAs called PIWI-interacting RNAs (piRNAs), which was hailed by the Science Magazine as one of the Ten Scientific Breakthroughs in 2006. He proposed and demonstrated the crucial role of piRNAs in epigenetic programming.
Dr. Lin has provided numerous services to the scientific community and beyond. Currently, he serves on 12 national and international advisory boards or equivalents, including Treasurer, Executive committee, and Board of Directors of the International Society for Stem Cell Research. He also serves on the editorial boards of seven international academic journals.
Dr. Lin received many awards and honors, including the Jane Coffin Childs Fellowship for Medical Research (1990), American Cancer Society Junior Faculty Research Award (1996), the March of Dimes Basil O'Connor Scholar Research Award (1996), the David and Lucile Packard Fellowship for Science and Engineering (1996), Member of the Connecticut Academy of Science and Engineering (2007-), the G. Harold and Leila Y. Mathers Award (2007, 2011), the American Society of Andrology Lecturer Award (2008), the Laura Hartenbaum Breast Cancer Foundation’s Legacy for Hope Award (2009), the Ellison Medical Foundation Senior Scholar Award (2010), the NIH Director’s Pioneer Award (2010), the NIH MERIT Award (2012), and the Ray Wu Award from the Chinese Biological Investigators Society (2013). He is an Elected Fellow of the American Association for the Advancement of Science (2010-).
1: Watanabe T, Lin H. Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs. Mol Cell. 2014 Oct 2;56(1):18-27. doi:
10.1016/j.molcel.2014.09.012. Review. PubMed PMID: 25280102; PubMed Central PMCID: PMC4185416.
2: Ross RJ, Weiner MM, Lin H. PIWI proteins and PIWI-interacting RNAs in the soma. Nature. 2014 Jan 16;505(7483):353-9. doi: 10.1038/nature12987. Review. PubMed PMID: 24429634; PubMed Central PMCID: PMC4265809.
3: Juliano CE, Reich A, Liu N, G tzfried J, Zhong M, Uman S, Reenan RA, Wessel GM, Steele RE, Lin H. PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):337-42. doi: 10.1073/pnas.1320965111. Epub 2013 Dec 23. PubMed PMID: 24367095; PubMed Central PMCID: PMC3890812.
4: Cheng EC, Lin H. Repressing the repressor: a lincRNA as a MicroRNA sponge in embryonic stem cell self-renewal. Dev Cell. 2013 Apr 15;25(1):1-2. doi: 10.1016/j.devcel.2013.03.020. PubMed PMID: 23597480; PubMed Central PMCID: PMC3906851.
5: Peng JC, Lin H. Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism. Curr Opin Cell Biol. 2013 Apr;25(2):190-4. doi: 10.1016/j.ceb.2013.01.010. Epub 2013 Mar 4. Review. PubMed PMID: 23465540; PubMed
Central PMCID: PMC3651849.
6: Huang XA, Yin H, Sweeney S, Raha D, Snyder M, Lin H. A major epigenetic programming mechanism guided by piRNAs. Dev Cell. 2013 Mar 11;24(5):502-16. doi: 10.1016/j.devcel.2013.01.023. Epub 2013 Feb 21. PubMed PMID: 23434410; PubMed Central PMCID: PMC3600162.
7: Lin H. Capturing the cloud: UAP56 in nuage assembly and function. Cell. 2012 Nov 9;151(4):699-701. doi: 10.1016/j.cell.2012.10.026. PubMed PMID: 23141532; PubMed Central PMCID: PMC4234066.
8: Beyret E, Liu N, Lin H. piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism. Cell Res. 2012 Oct;22(10):1429-39. doi: 10.1038/cr.2012.120. Epub 2012 Aug 21. PubMed PMID: 22907665; PubMed Central PMCID: PMC3463270.
9: Yin H, Sweeney S, Raha D, Snyder M, Lin H. A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. PLoS Genet. 2011 Dec;7(12):e1002380. doi: 10.1371/journal.pgen.1002380. Epub 2011 Dec 15.
PubMed PMID: 22194694; PubMed Central PMCID: PMC3240582.
10: Gangaraju VK, Yin H, Weiner MM, Wang J, Huang XA, Lin H. Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nat Genet. 2011 Feb;43(2):153-8. doi: 10.1038/ng.743. Epub 2010 Dec 26. PubMed PMID: 21186352;
PubMed Central PMCID: PMC3443399.
11: McKay RD, van der Kooy D, Zwaka TP, Lin H. Stem cells in 2009. Cell Stem Cell. 2009 Nov 6;5(5):483-9. doi: 10.1016/j.stem.2009.10.012. PubMed PMID:19896440.
12: Szakmary A, Reedy M, Qi H, Lin H. The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster. J Cell Biol. 2009 May 18;185(4):613-27. doi: 10.1083/jcb.200903034. Epub 2009 May
11. PubMed PMID: 19433453; PubMed Central PMCID: PMC2711570. 13: Gangaraju VK, Lin H. MicroRNAs: key regulators of stem cells. Nat Rev Mol Cell Biol. 2009 Feb;10(2):116-25. doi: 10.1038/nrm2621. Review. PubMed PMID:
19165214; PubMed Central PMCID: PMC4118578.
14: Lin H. Cell biology of stem cells: an enigma of asymmetry and self-renewal. J Cell Biol. 2008 Jan 28;180(2):257-60. doi: 10.1083/jcb.200712159. PubMed PMID: 18227277; PubMed Central PMCID: PMC2213586.
15: Thomson T, Lin H. The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. Annu Rev Cell Dev Biol. 2009;25:355-76. doi: 10.1146/annurev.cellbio.24.110707.175327. Review. PubMed PMID: 19575643; PubMed Central PMCID: PMC2780330.
16: Yin H, Lin H. An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature. 2007 Nov 8;450(7167): 304-8. Epub 2007 Oct 21. PubMed PMID: 17952056.
17: Lin H. piRNAs in the germ line. Science. 2007 Apr 20;316(5823):397. Review. PubMed PMID: 17446387.
18: Wang Z, Lin H. Nanos maintains germline stem cell self-renewal by preventing differentiation. Science. 2004 Mar 26;303(5666):2016-9. Epub 2004 Feb 19. PubMed PMID: 14976263.
19: Lin H. Stem cells: to be and not to be. Nature. 2003 Sep 25;425(6956):353-5. PubMed PMID: 14508468.
20: Lin H. The stem-cell niche theory: lessons from flies. Nat Rev Genet. 2002 Dec;3(12):931-40. Review. PubMed PMID: 12459723.