Shin-Chen Hou, Ph. D.

发布者:免疫所发布时间:2019-11-15浏览次数:10

  Shin-Chen Hou, Ph. D.
Research Assistant Professor, Lab of Antibody Engineering

Address: Room 307, Building 6, No.99 Haike Road, Pudong District, Shanghai, China

Email: houxc@@shanghaitech.edu.cn


Education:

Ph.D Molecular Biology, Genetics, and Development, Academia Sinica / National Defense Medical Center, Taipei, Taiwan, 2009

MS    Molecular Biology, National Taiwan University, Taipei, Taiwan, 2001

BS     Chung Hsing, University, Taichung, Taiwan, 1999


Professional:

July 2016-present, Research Assistant professor, Shanghai Advanced Immunochemical Studies (SIAIS), Shanghaitech University, Shanghai, China

May 2016-June 2016, Senior scientist, OBI pharma Inc., Taipei, Taiwan

June 2011-May 2016, Postdoctoral Fellow, Academia Sinica, Genomics Research Center, Taipei, Taiwan

Oct. 2010-May 2011, Postdoctoral Fellow, China Medical University, Department of Biological Science and Technology, Taichung, Taiwan

Feb. 2009-Sept. 2009, Postdoctoral Fellow, Academia Sinica, Institute of Molecular Biology, Taipei, Taiwan


Research Interest:

Therapeutic antibody development, Synthetic antibody, Antibody engineering and Cancer biology.


Patents:

1. Yang AS, Chen HS, Hou SC. 2015. A phage-displayed antibody library. under International application.
2. Yang AS, Hou SC, Chen HS, Yu CM. 2016. A high-throughput antibody engineering platform for discovering and optimizing antibodies in antibody-guided drug delivery systems. under provisional application


Publications:

1. Liu JJ, Hou SC, and Shen CK. 2003. Erythroid gene suppression by NF-kappa B. J Biol Chem. 278 (21): 19534-40.
2. Hou SC, Chan LW, Chou YC, Su CY, Chen X, Shih YL, Tsai PC, and Shen CK, Yan YT. 2009. Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis. FEBS Lett. 583 (17): 2765-71.
3. Wu LS*, Cheng WC*, Hou SC*, Yan YT, Jiang ST, and Shen CK. 2010. TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis. Genesis 48 (1): 56-62. (*Wu, Cheng, and Hou. Equal contribution to this paper)
4. Wang IF, Chang HY, Hou SC, Liou GG, Way TD, and Shen CKJ. 2012. The self-interaction of native TDP-43 C terminus inhibits its degradation and contributes to early proteinopathies. Nat. Commun. 3:766.
5. Lin HY, Hou SC, Chen SC, Kao MC, Yu CC, Funayama S, Ho CT, and Way TD. 2012. (-)-Epigallocatechin gallate induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling in head and neck squamous cell carcinoma cells. J Agric Food Chem. 60(10): 2480-2489.
6. Chang HJ, Jian JW, Hsu HJ, Lee YC, Chen HS, Yu CJ, Hou SC, Shao CY, Chen YJ, Chiu KP, Peng HP, Lee KH, and Yang AS. 2014. Loop-Sequence Features and Stability Determinants in Antibody Variable Domains by High-Throughput Experiments. Structure 22(1): 9-21
7. Chang HY, Hou SC, Way TD, Wong CH, Wang IF. 2014. Heat-shock protein dysregulation is associated with functional and pathological TDP-43 aggregation. Nat. Commun. 4: 2757.
8. Lin YC, Hou SC, Hung CM, Lin JN, Chen WC, Ho CT, Kuo SC, Way TD. 2015. Inhibition of the insulin-like growth factor 1 receptor by CHM-1 blocks proliferation of glioblastoma multiforme cells. Chem Biol Interact. 231:119-26
9. Chen HS*, Hou SC*, Jian JW, Goh KS, Shen ST, Lee YC, You JJ, Peng HP, Kuo WC, Chen ST, Peng MC, Wang HJ, Yu CM, Chen IC, Tung CP, Chen TH, Chiu KP, Ma C, Wu CY, Lin SW, Yang AS. 2015. Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens. Scientific Reports 5:12411. (*Chen, and Hou. Equal contribution to this paper)
10. Hou SC*, Chen HS*, Lin HW, Chao WT, Chen YS, Fu CY, Yu CM, Huang YF, Andrew H.-J. Wang A HJ, Yang AS. 2016. High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries. Scientific Reports 6:31878. (*Hou, and Chen. Equal contribution to this paper)


Oral presentations in conferences:

1. Hou SC. 2000. Isolation and characterization of a t-dna tagged mutant with altered root development in response to n-starvation. The 6th International Congress of Plant Molecular Biology, section 8-18, International Society for Plant Molecular Biology (ISPMB), 18-24 June 2000.Quebec City, Canada.
2. Hou SC. 2008. The role of Ankrd17 in mouse embryonic development. Developmental Retreat sponsored by Institute of Molecular Biology, Academia Sinica, Department of Genetics, National Yang-Ming University, and Department of Life Sciences, National Chung Hsing University. 28 August 2008. Taichung, Taiwan.