Michael Levitt, Ph.D.

发布者:免疫所发布时间:2019-11-15浏览次数:22

  Michael Levitt, Ph.D.

Distinguished Adjunct Professor

Principal Investigator
Lab of Computational Biology

Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University

Research Area: Computaional Biology
Email: mlevitt@@shanghaitech.edu.cn

Biography

1964-1967 B.Sc. Special Degree in Physics, King's College, London, UK.
1968-1971 Ph.D. in Biophysics, MRC Laboratory of Molecular Biology and Cambridge University, Cambridge, UK.
1972-1974 EMBO Postdoctoral Fellow with Shneior Lifson, Weizmann Institute, Rehovot, Israel
1974 - 1979 Staff Scientist, MRC Laboratory Molecular Biology, Cambridge, England.
1977 - 1979 Visiting Scientist with Francis Crick, Salk Institute, La Jolla, California.
1979 - 1987 Associate & Full Professor of Chemical Physics, Department of Chemical Physics,Weizmann Institute, Israel. Chair from 1980-1983; Full Professor from 1984.
1987 - Professor of Structural Biology, Department of Structural Biology, Stanford University School of Medicine, Stanford. Chair from 1993 till 2004.
April 4,2018- Distinguished Professor-in-Residence , SIAIS, ShanghaiTech University

Research Interests

Methodology for Simulation of Biological Macromolecules; Predicting protein structure from sequence; Modeling and prediction of RNA structure; Mesoscale modeling of large macromolecular complexes; Combinatorial Homology Modeling; Protein Structure, Sequence & Function; Antibody Modeling and Humanized Antibody Therapeutics

Selected Publications

  

Chopra, G., Summa, C., Levitt, M.  Solvent Dramatically Affects Protein Structure Refinement. Proc.  Natl. Acad. Sci. USA, 105: 20239-20244 (2008).

Chopra, G. Levitt, M.  Remarkable patterns of surface water ordering around polarized buckminsterfullerene. Proc. Natl. Acad. Sci. USA, 108: 14455-14460 (2011).

Sim, A. Y. L., Levitt, M.  Clustering to identify RNA conformations constrained by secondary structure. Proc. Natl. Acad. Sci. USA, 108: 3590-3595 (2011).

Bernauer, J., Huang, X., Sim, A. Y. L., Levitt, M.  Fully differentiable coarse-grained and all-atom knowledge-based potentials for RNA structure evaluation. RNA 17: 1066-1075(2011).

Bray, J. K., Weiss, D. R., Levitt, M.  Optimized Torsion-Angle Normal Modes Reproduce Conformational Changes More Accurately Than Cartesian Modes. Biophysical J., 101: 2966-9 (2011).

Minary, P., Levitt, M.  Training-Free Atomistic Prediction of Nucleosome Occupancy. Proc. Natl. Acad. Sci. USA111: 6293-6298 (2014).

Silva, D.A., Weiss, D.R., Avila, F.P., Da, T.T., Levitt, M., Wang, D., Huang, X.  Millisecond dynamics of RNA polymerase II translocation at atomic resolution. Proc. Natl. Acad. Sci. USA111, 7665-7670 (2014).

Levitt, M.  Birth and Future of Multiscale Modeling for Macromolecular Systems (Nobel Lecture). Angew. Chem. Int. Ed. doi:10.1002/anie.201403691 (2014).

Kalisman, N., Adams C. M., Levitt, M.  Subunit Order of Eukaryotic TRiC/CCT Chaperonin by Cross-linking, Mass Spectrometry and Combinatorial Homology Modeling. Proc. Natl. Acad. Sci. USA, 109: 2884-2889 (2012).

Brunger, A. T., Adams, P. D., Fromme, P., Fromme, R., Levitt, M., Schröder, G. F.  Improving the Accuracy of Macromolecular Structure Refinement at 7 Å Resolution. Structure 20: 957-966 (2012).

Zhang, J., Minary, P., Levitt, M.  Multi-scale Natural Moves Refine Macromolecules Using Single-particle Electron Microscopy Projection Images. Proc. Natl. Acad. Sci. USA 109:9845-50 (2012).

Kalisman, N., Schröder, G. F., Levitt, M.  The Crystal Structures of the Eukaryotic Chaperonin CCT Reveal its Functional Partitioning. Structure 21: 540-9 (2013).

Murakami, K., Elmlund, H., Kalisman, N., Bushnell, D. A., Adams, C. M., Azubel, M., Elmlund, D., Levi-Kalisman, Y., Liu, X., Gibbons, B. J., Levitt, M., Kornberg, R. D.  Architecture of an RNA polymerase II transcription pre-initiation complex. Science 342: 1238724 (2013).