​Recently, the Laboratory of Structural Biochemistry at SIAIS, led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao, published a research article entitled “Class I histone deacetylase complex: structure and functional correlates” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a 3.2 Å resolution cryo-EM structure of the class I histone deacetylase (HDAC) complex.

​Recently, a group led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao of the laboratory of structure biochemistry at SIAIS, published a paper entitled “Structure of the NuA4 histone acetyltransferase complex” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a near-atomic resolution structure of the NuA4 complex in eukaryotes obtained by cryo-electron microscopy (cryo-EM).

Assistant Professor Liu Jia’s group at SIAIS along with his collaborator, Professor Qu Jieming at Ruijin Hospital designed a novel surfaceome CRISPR library and identified OLFML3 as a novel host factor of rhinovirus (RV).

SIAIS Prof. Katsuhiko Mikoshiba with research team led by Prof. Hideki Nishitoh at Miyazaki University revealed a new mechanism ofbrain atrophy regulated by ER chaperon Derlin which involves in cholesterol metabolism. published in iScience in July 23rd2021.Cells degrade the unfolded proteins in order to prevent accumulation of misfolded proteins due to pathological endoplasmic reticulum (ER) stress. Derlin as a member of ER-associated degradation (ERAD) complex eliminates the misfolded proteins