I. Development of therapeutic antibody against specific targets by combinatorial antibody libraries:
Human combinatorial antibody libraries contain 1011 diversity. We apply this antibody libraries to therapeutic targets in major diseases such as cancer, diabetes and neuronal diseases. New functional antibodies may provide novel therapeutic strategies for diseases.
II. Unbiased functional antibody screening by combinatorial antibody libraries:
We have established an efficient method for identification of novel therapeutic targets by using combinatorial antibody libraries. In this method, we screen functional antibodies against specific disease models and identify the targets by proteomic analysis. By this approaches, we are aiming to discover novel therapeutic targets and propose new functional antibodies.