The state-of-the-art services the platform carry out include synthetic molecules characterization, protein identification/quantitation, protein-protein interaction, and protein structure, dynamics analysis, Glycosylation analysis, etc.
•Protein Identification service. The service identify proteins from solutions or gel bands.
•Quantitative proteomics analysis. The service measure relative protein abundance using Label free, SILAC, iTRAQ and TMT techniques. We accept samples from cells, tissues and serum.
•Protein Structure Analysis. Both chemical crosslinking MS and HDX-MS techniques are employed to study dynamic protein conformation, protein-protein interactions, and protein-small molecular interactions.
•Metabolites characterization. We provide identification services for metabolites mixtures and quantification services for target metabolites.
•Synthetic molecules characterization. We provide both identification and quantification services for synthetic molecules and oligonucleotides by using LC-MS, GCMS and NMR techniques.
•Antibody characterization services.
1.Accurate mass determination for mAb, ADC, biosimilars, fusion proteins
2.Disulfide bond mapping
3.mAb denovo sequencing
4.PTM mapping including glycosylation
5.Aggregation, purity and charge variants characterization
Table 1. Functions of SIAIS Analytical Platform