Co-Principal Investigator, Research Associate Professor
Laboratory: Lab of Structural Biochemistry
Research Interest: Elucidation the molecular mechanism of eukaryotic transcriptional regulation by transcriptional activators and Mediator complex through Cryo-EM. The molecular mechanism of histone modifications.
Email: zhanghq@@shanghaitech.edu.cn 
Biography:
2019.04-2020.09 Visiting scholar, Department of Structural Biology, School of Medicine, Stanford University, USA. 2017.12-2018.06 Visiting associate professor, Department of Structural Biology, School of Medicine, Stanford University, USA. 2021.07-present Research Associate Professor, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, China. 2017.01-2021.07 Research Assistant Professor, Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, China. 2016.07-2016.12 Senior Scientist, Shanghai Hengrui Pharmaceutical CO. LTD., Shanghai, China. 2013.09–2016.06 Ph.D., School of Life sciences, Tsinghua University (Supervisor: Prof. Jijie Chai), Beijing, China. 2010.09–2013.06 M.S., Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. 2006.09–2010.06 B.S., Hebei University of Technology, Tianjin, China. 
Selected Scholarships, Awards, & Honors: 2016.06 Life Science Research Award,Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. 2014.10 Comprehensive Excellent Scholarship, Tsinghua University, Beijing, China.
Selected publications:
1. Ji, L., Zhao, L., Xu, K., Gao, H., Zhou, Y., Kornberg, R.D #., and Zhang, H #. (2022). Structure of the NuA4 histone acetyltransferase complex. Proc Natl Acad Sci U S A 119, e2214313119. (#Co-corresponding author). 2. Zhang, H*., Chen, D.H., Mattoo, R.U.H., Bushnell, D.A., Wang, Y., Yuan, C., Wang, L., Wang, C., Davis, R.E., Nie, Y., Roger D. Kornberg. (2021). Mediator structure and conformation change. Mol Cell 81, 1781-1788 e1784. (*first author). 3. Wang, Y., Graham, L.A., Han, Z., Eves, R., Gruneberg, A.K., Campbell, R.L., Zhang, H #., and Davies, P.L. # (2020). Carrot 'antifreeze' protein has an irregular ice-binding site that confers weak freezing point depression but strong inhibition of ice recrystallization. Biochem J 477, 2179-2192. (# Co-corresponding author). 4. Wang, Y., Zhang, F., Nie, Y #., Shang, G #., and Zhang, H#. (2019). Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis.Biochem Biophys Res Commun 516, 540-545. (# Co-corresponding author). 5. Zhang, H *., Lin, X *., Han, Z., Qu, L.J., and Chai, J. (2016). Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs. Cell Res 26, 543-555. (*co-first author). 6. Zhang, H *., Lin, X *., Han, Z., Wang, J., Qu, L.J., and Chai, J. (2016). SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular Development. Mol Plant 9, 1406-1414. (*co-first author). 7. Zhang, H *., Han, Z., Song, W., and Chai, J. (2016). Structural Insight into Recognition of Plant Peptide Hormones by Receptors. Mol Plant 9, 1454-1463. (*first author). 8. Lu, D*., Shang, G*., Zhang, H*., Yu, Q*., Cong, X., Yuan, J., He, F., Zhu, C., Zhao, Y., Yin, K., et al. (2014). Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism. Mol Microbiol 92, 1092-1112. (*co-first author). 9. Zhang, X., Liu, W., Nagae, T.T., Takeuchi, H., Zhang, H., Han, Z., Higashiyama, T., and Chai, J. (2017). Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun 8, 1331. 10. Ma, C., Liu, Y., Bai, B., Han, Z., Tang, J., Zhang, H., Yaghmaiean, H., Zhang, Y., and Chai, J. (2017). Structural basis for BIR1-mediated negative regulation of plant immunity. Cell Res 27, 1521-1524. 11. Wu, Z., Liang, S., Song, W., Lin, G., Wang, W., Zhang, H., Han, Z., and Chai, J. (2017). Functional and Structural Characterization of a Receptor-Like Kinase Involved in Germination and Cell Expansion in Arabidopsis. Front Plant Sci 8, 1999. 12. Ma, R., Han, Z., Hu, Z., Lin, G., Gong, X., Zhang, H., Nasrallah, J.B., and Chai, J. (2016). Structural basis for specific self-incompatibility response in Brassica. Cell Res 26, 1320-1329. 13. Song, W., Liu, L., Wang, J., Wu, Z., Zhang, H., Tang, J., Lin, G., Wang, Y., Wen, X., Li, W., et al. (2016). Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Res 26, 674-685. 14. Liu, S., Wang, J., Han, Z., Gong, X., Zhang, H., and Chai, J. (2016). Molecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP.Structure 24, 1192-1200. 15. Wang, J., Li, H., Han, Z., Zhang, H., Wang, T., Lin, G., Chang, J., Yang, W., and Chai, J. (2015). Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature 525, 265-268. 16. Song, W., Wang, J., Han, Z., Zhang, Y., Zhang, H., Wang, W., Chang, J., Xia, B., Fan, S., Zhang, D., et al. (2015). Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nat Struct Mol Biol 22, 782-787. 17. Tang, J., Han, Z., Sun, Y., Zhang, H., Gong, X., and Chai, J. (2015). Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1. Cell Res 25, 110-120. 18. Albert, I., Bohm, H., Albert, M., Feiler, C.E., Imkampe, J., Wallmeroth, N., Brancato, C., Raaymakers, T.M., Oome, S., Zhang, H., et al. (2015). An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity. Nat Plants 1, 15140. 19. Wang, J., Wang, W., Song, W., Han, Z., Zhang, H., Chai, J., Wang, H., and Wang, J. (2015). An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data. Protein Cell 6, 919-923.
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