​Recently, a group led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao of the laboratory of structure biochemistry at SIAIS, published a paper entitled “Structure of the NuA4 histone acetyltransferase complex” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a near-atomic resolution structure of the NuA4 complex in eukaryotes obtained by cryo-electron microscopy (cryo-EM).

Assistant Professor Liu Jia’s group at SIAIS along with his collaborator, Professor Qu Jieming at Ruijin Hospital designed a novel surfaceome CRISPR library and identified OLFML3 as a novel host factor of rhinovirus (RV).

SIAIS Prof. Katsuhiko Mikoshiba with research team led by Prof. Hideki Nishitoh at Miyazaki University revealed a new mechanism ofbrain atrophy regulated by ER chaperon Derlin which involves in cholesterol metabolism. published in iScience in July 23rd2021.Cells degrade the unfolded proteins in order to prevent accumulation of misfolded proteins due to pathological endoplasmic reticulum (ER) stress. Derlin as a member of ER-associated degradation (ERAD) complex eliminates the misfolded proteins

SIAIS Prof. Katsuhiko Mikoshiba with research team led by Prof. Schuichi Koizumi of Yamanashi Univ.unraveled the mechanism ofsequential activation of glial cells (microglia and then astrocyte) constitutesa cause of epileptogenesis, where IP3Receptor type 2 (IP3R2) in astrocyte plays a major role in the increased susceptibility to seizures published in J. Clinical Investigations in May 21st 2021. Epileptogenesis is a common sequel of brain insults such as brain injury.Status epilepticus is a cond