Sebastian Martewicz, Ph.D.

publisher:董怡霄publishTime:2019-11-26Views:192

  Sebastian Martewicz, Ph.D. 


Research Assistant Professor
Laboratory: Lab of Biological Engineering

E-mail: smartewicz@@shanghaitech.edu.cn



Research Interests: 

Mechanobiology of the cell nucleus: molecular mechanisms of nuclear shape changes during differentiation of immune system cells and cancer cell in 3D environments.

Stem cell cardiac differentiation and cardiac disease modeling with hPSCs. 

Biography: 

2019-Present: Research Assistant Professor, SIAIS, ShanghaiTech University, Shanghai, China
2016-2019: Postdoctoral Researcher, SIAIS, ShanghaiTech University, Shanghai, China

2015-2016: Postdoctoral Researcher, University of Padua, Italy

2015 Ph.D. in Biosciences and Biotechnology, University of Padua, Italy

2014 Visiting PhD student, Sanford-Burnham Medical Research Institute, La Jolla, California, USA

2010-2011 Research assistant University of Padua, Italy
2010 M.Sc. in Industrial Biotechnology, University of Padua, Italy
2008 B.Sc. in Biotechnology, University of Padua, Italy

Selected Grants, Honors and Awards:

2018 Excellent Employee Award, ShanghaiTech University, Shanghai, China

2012-2014 PhD Fellowship by Citta’ della Speranza Foundation, Padua, Italy

 

Publications:

·        Martewicz S*, Magnussen M, Elvassore N. “Beyond Family: modeling non-hereditary heart diseases with human pluripotent stem cell-derived cardiomyocytes” Frontiers in Physiology. 2020 doi: 10.3389/fphys.2020.00384

·        Beninatto R, Barbera C, De Lucchi O, Borsato G, Serena E, Guarise C, Pavan M, Luni C, Martewicz S, Galesso D, Elvassore N. “Photocrosslinked hydrogels from coumarin derivatives of hyaluronic acid for tissue engineering applications” Materials Scince and Engineering C. 2019 doi:10.1016/j.msec.2018.11.052

·        Martewicz S#, Luni C#, Serena E, Pavan P, Chen HSV, Rampazzo A, Elvassore N. “Transcriptomic characterization of a human in vitro model of arrhythmogenic cardiomyopathy under topological and mechanical stimuli” Annals of Biomedical Engineering, 2019 doi:10.1007/s10439-018-02134-8

·        Martewicz S, Gabrel G, Campesan M, Canton M, DiLisa F, Elvassore N.
 “Live cell imaging in microfluidic device proves resistance to oxygen/glucose deprivation in hiPS-CMs” Analytical Chemistry, 2018
doi:10.1021/acs.analchem.7b05347 

·        Martewicz S, Serena E, Zatti S, Keller G, Elvassore N.
 “Substrate and mechanotransduction influence SERCA2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performance” Stem Cell Research, 2017
doi:10.1016/j.scr.2017.10.011

·        Grespan E, Martewicz S, Serena E, Le Houérou V, Ruehe J, Elvassore N. Analysis of calcium dynamics and uni-axial contraction force in single human embryonic stem cell derived-cardiomyocytes  on micro-structured elastic substrate with spatially controlled surface chemistries Langmuir, 2016 doi:10.1021/acs.langmuir.6b03138

·        Giobbe G, Michielin F, Luni C, Giulitti S, Martewicz S, Dupont S, Floreani A, Elvassore N. “Functional differentiation of human pluripotent stem cells on a chip.” Nature Methods. 2015  doi:10.1038/nmeth.3411

·        Zatti S, Martewicz S, Serena E, Uno N, Giobbe G, Kazuki Y, Oshimura M, Elvassore N. Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne Muscular Dystrophy patient-derived cardiomyocytesMolecular Therapy – Methods and Clinical Development, 2014 doi:10.1038/mtm.2013.1

·        Martewicz S#, Michielin F#, Serena E, Zambon A, Mongillo M, Elvassore N. Reversible alteration of calcium dynamics in cardiomyocytes during acute hypoxia transient in a microfluidic platform”. Integrative Biology (Camb). 2012  doi: 10.1039/c1ib00087j