New-to-Nature Chemical Tools for Studying Bacterial Glycans and Its Transport
Speaker: Dr. Ran Xie 谢然
Chemical Biology, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center, Nanjing University
Invited by Dr. Lu Zhang
Time: 14:30, Oct. 27 (Tuesday), 2020
Venue: B808 at Y Building 人字楼 B808
Glycosylation plays pivotal roles in various cellular processes. In biology, glycosylation mainly refers in particular to the enzymatic process that attaches glycans to proteins, or other organic molecules. This enzymatic process produces one of the fundamental biopolymers found in cells (along with DNA, RNA, and proteins). Glycosylation is a form of co-translational and post-translational modification. Glycans serve a variety of structural and functional roles in membrane and secreted proteins. Employing new-to-nature chemistry to decipher biological functions of glycan, as well as to fulfil glycan-based therapeutic need, remains a major challenge.
In this seminar, we will present the recent development of liposaccharide membrane-to-membrane movement system. A brief report on how cutting-edge chemical tools are used to study its transport function will also be discussed.