科学研究

2023

  1. Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling. Yafang Wang(1);Mingyue Yao(1,2,3);Cheng Li (1,4);Kexin Yang(4,5);Xiaolong Qin(1,4);Lansong Xu(1,2,3);Shangxuan Shi(1,4);Chengcheng Yu(3,5);Xiangjun Meng(6,7,8);Chengying Xie(1,4,5);2023;12; EXPERIMENTAL HEMATOLOGY & ONCOLOGY; 2023-12-16

  2. Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Wang, Haofeng(1,2,3);Yang, Qi(4);Liu, Xiaoce(1,2,3);Xu, Zili(5,6);Shao, Maolin(1,2,3);Li, Dongxu(1,2,3);Duan, Yinkai(1,2,3);Tang, Jielin(4);Yu, Xianqiang(1,2,6);Zhang, Yumin(7);Hao, Aihua(8,9);Wang, Yajie(8,9);Chen, Jie(1,2,3);Zhu, Chenghao(1,2);Guddat, Luke(10);Chen, Hongli(1,2,6);Zhang, Leike(7);Chen, Xinwen(4);Jiang, Biao(1,2,6);Sun, Lei(8,9);Rao, Zihe(1,2,3,4,11,12,13,14,15);Yang, Haitao(1,2,3);2023;14; NATURE COMMUNICATIONS; 2023-11-21

  3. Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs. Han, Wenyan(1);Qiu, Hou-Yuan(2);Sun, Shangwu(1,3);Fu, Zhi-Can(4,5);Wang, Guo-Quan(2);Qian, Xiaowen(6);Wang, Lijie(7);Zhai, Xiaowen(6);Wei, Jia(5);Wang, Yichuan(7);Guo, Yi-Lin(5);Cao, Guo-Hua(2);Ji, Rui-Jin(2);Zhang, Yi-Zhou(2);Ma, Hongxia(7);Wang, Hongsheng(6);Zhao, Mingli(1);Wu, Jing(1);Bi, Lili(2);Chen, Qiu-Bing(2);Li, Zifeng(6);Yu, Ling(6);Mou, Xiaodun(7);Yin, Hao(2,8,9,12);Yang, Li(5);Chen, Jia(1,10,11);Yang, Bei(1,3,10);Zhang, Ying(2,12);2023;30; CELL STEM CELL; 2023-11

  4. Tunable Hydrogel Confinement via On-Chip 3D Printing for Studying Cancer Cell Migration. Qian, Shuyi(1,2,3);Dong, Yixiao(1,2,3);Qu, ju(1,3);Wang, Xuechun(1,3);Zhang, Wang(1,2,3);Chen, Jia(1,2);Xu, Fan(5);Cui, Meihua(1);Giomo, Monica(4);Liao, Chenhan(1,2,3);Hu, Manli(1);Xu, Juan(8);Hu, Ganlu(1,2);Zheng, Jie(5,6);Zhu, Xianmin(1,2);Urciuolo, Anna(4,7);Fan, Guoping(1,2,10);Elvassore, Nicola(1,4,9); ACS MATERIALS LETTERS; 2023-11-09

  5. DeepSA: a deep-learning driven predictor of compound synthesis accessibility. Shihang Wang(1);Lin Wang(1);Fenglei Li(2);Fang Bai(1,2,3);2023;15; JOURNAL OF CHEMINFORMATICS; 2023-11-02

  6. A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains. Yao, Hebang(1);Wang, Hongyang(1);Zhang, Zhaoyong(2);Lu, Yuchi(1,3);Zhang, Zhiying(1);Zhang, Yu(1);Xiong, Xinyi(1);Wang, Yanqun(2,4);Wang, Zhizhi(1);Yang, Haitao(1,3);Zhao, Jincun(2,3,5,6,7);Xu, Wenqing(1); 2023;4; MEDCOMM; 2023-10-26

  7. Structural biology and inhibition of the Mtb cell wall glycoconjugates biosynthesis on the membrane. Zhang, Lu(1);Rao, Zihe(2); 2023;82; CURRENT OPINION IN STRUCTURAL BIOLOGY; 2023-10-01

  8. Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Gao, Chao(1);Jiang, Jingwen(1);Tan, Yuyan(1);Chen, Shengdi(1,2); 2023;8; SIGNAL TRANSDUCTION AND TARGETED THERAPY; 2023-09-22

  9. Claudin18.2 bispecific T cell engager armed oncolytic virus enhances antitumor effects against pancreatic cancer. Liu, Shiyu(1,2,3,4,5);Li, Fan(2,3,4,5);Deng, Li(4,5);Ma, Qiongqiong(2,3,4,5);Lu, Wenyi(6);Zhao, Zhuoqian(1,2,3,4,5);Liu, Huanzhen(1);Zhou, Yixuan(7);Hu, Manli(1);Wang, Hui(4,5);Yan, Yingbin(7);Zhao, Mingfeng(6);Zhang, Hongkai(1,2,3,4,5);Du, Mingjuan(1); 2023;30; MOLECULAR THERAPY-ONCOLYTICS; 2023-09-21

  10. Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Duan, Yinkai(1,2,3);Zhou, Hao(1,2,3);Liu, Xiang(4);Iketani, Sho(5,6);Lin, Mengmeng(1,2,7);Zhang, Xiaoyu(1,2,3,8);Bian, Qucheng(1,2,3);Wang, Haofeng(1,2,3);Sun, Haoran(1,2,3);Hong, Seo Jung(9);Culbertson, Bruce(10,11,12);Mohri, Hiroshi(5,6);Luck, Maria I.(5,6);Zhu, Yan(1,2,3);Liu, Xiaoce(1,2,3);Lu, Yuchi(1,2,3,8);Yang, Xiuna(1,2,3);Yang, Kailin(13);Sabo, Yosef(5,6);Chavez, Alejandro(9,12);Goff, Stephen P.(5,14,15);Rao, Zihe(1,2,16,17,18,19,20);Ho, David D.(5,6,14);Yang, Haitao(1,2,3); 2023;622; NATURE; 2023-09-11

  11. Development of a MMAE-based antibody-drug conjugate targeting B7-H3 for glioblastoma. Mao, Yurong(1,2);Wei, Ding(1,2);Fu, Fengqing(4,5);Wang, Huihui(1,2);Sun, Ziyu(1,2);Huang, Ziyi(4);Wang, Yan(5,7);Zhang, Guangbo(4);Zhang, Xueguang(4,5,6);Jiang, Biao(1,2,3);Chen, Hongli(1,2,3); 2023;257; EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; 2023-09-05

  12. Applications of macrocyclic molecules in cancer therapy: Target cancer development or overcome drug resistance. Xiaoling Song(1);Yifan Wu(1,2);Xiaojuan Qu(1,2);Biao Jiang(1,3); 2023;2; MEDCOMM-ONCOLOGY; 2023-09-04

  13. Molecular recognition of trehalose and trehalose analogues by  Mycobacterium tuberculosis  LpqY-SugABC. Liang, Jingxi(1,2,3);Liu, Fengjiang(4);Xu, Peng(5);Shangguan, Wei(5);Hu, Tianyu(2,3);Wang, Shule(2,3);Yang, Xiaolin(2,3);Xiong, Zhiqi(6);Yang, Xiuna(2,3,7);Guddat, Luke W.(8);Yu, Biao(5);Rao, Zihe(1,2,3,4,6,7);Zhang, Bing(2,3,7);2023;120; PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; 2023-08-21

  14. Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs. Niu, Jun(1,2,3,4);Wang, Qi(1,2);Zhao, Wenwen(1,2);Meng, Bing(1,2);Xu, Youwei(1,2);Zhang, Xianfang(1,2);Feng, Yi(5);Qi, Qilian(1,2);Hao, Yanling(5);Zhang, Xuan(1,2);Liu, Ying(5);Xiang, Jiangchao(1,2);Shao, Yiming(5,6);Yang, Bei(1,2,7); 2023;14; NATURE COMMUNICATIONS; 2023-08-04

  15. Structural biology of SARS-CoV-2 Mpro and drug discovery. Duan, Yinkai(1,2);Wang, Haofeng(1,2);Yuan, Zhenghong(3,4);Yang, Haitao(1,2); 2023;82; CURRENT OPINION IN STRUCTURAL BIOLOGY; 2023-08-04

  16. Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group. Ren, Pengxuan(1,2);Li, Hui(3,4);Nie, Tianqing(4);Jian, Xiaoqin(5);Yu, Changyue(4);Li, Jian(4);Su, Haixia(4);Zhang, Xianglei(1,2);Li, Shiwei(1,2);Yang, Xin(1,2);Peng, Chao(6);Yin, Yue(6);Zhang, Leike(5);Xu, Yechun(4,7);Liu, Hong(3,4,7);Bai, Fang(1,2,8,9); JOURNAL OF MEDICINAL CHEMISTRY; 2023-08-01

  17. Class I histone deacetylase complex: Structure and functional correlates. Wang, Xiao(1,2);Wang, Yannan(1);Liu, Simiao(3);Zhang, Yi(1);Xu, Ke(1,2);Ji, Liting(1,2);Kornberg, Roger D.(1,4);Zhang, Heqiao(1); 2023;120; PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; 2023-07-17

  18. Enolate-Azide [3+2]-Cycloaddition Reaction Suitable for DNA-Encoded Library Synthesis. Pan, Kangyin(1);Yao, Ying(1);Zhang, Yiyuan(1);Gu, Yuang(1);Wang, Yan(1);Ma, Peixiang(2);Hou, Wei(3);Yang, Guang(1);Zhang, Shuning(1);Xu, Hongtao(1); 2023;34; BIOCONJUGATE CHEMISTRY; 2023-07-01

  19. Cryo-EM structures of a prokaryotic heme transporter CydDC. Zhu, Chen(1,2,3);Shi, Yanfeng(1,2);Yu, Jing(1,2);Zhao, Wenhao(1,2);Li, Lingqiao(1,2);Liang, Jingxi(5);Yang, Xiaolin(1,2,3);Zhang, Bing(1,2);Zhao, Yao(1,2,3);Gao, Yan(1,2);Chen, Xiaobo(1,2);Yang, Xiuna(1,2);Zhang, Lu(1,2);Guddat, Luke W.(7);Liu, Lei(3);Yang, Haitao(1,2);Rao, Zihe(1,2,3,4,5,6);Li, Jun(1,2,3); 2023;14; PROTEIN & CELL; 2023-05-01

  20. MolFilterGAN: a progressively augmented generative adversarial network for triaging AI-designed molecules. Liu, Xiaohong(1,2,3,4);Zhang, Wei(2,3);Tong, Xiaochu(2,3);Zhong, Feisheng(2,3);Li, Zhaojun(4);Xiong, Zhaoping(1,2,3);Xiong, Jiacheng(2,3);Wu, Xiaolong(2,6);Fu, Zunyun(2);Tan, Xiaoqin(2,3,5);Liu, Zhiguo(4);Zhang, Sulin(2,3);Jiang, Hualiang(1,2,3);Li, Xutong(2,3);Zheng, Mingyue(2,3,7); 2023;15; JOURNAL OF CHEMINFORMATICS; 2023-04-08

  21. Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation (vol 223, 113645, 2021). Liu, Haixia(1,3,5);Ding, Xinyu(1,2,5);Liu, Linyi(4);Mi, Qianglong(1,2);Zhao, Quanju(1);Shao, YuBao(6);Ren, Chaowei(1,2);Chen, Jinju(1);Kong, Ying(1);Qiu, Xing(7);Elvassore, Nicola(1);Yang, Xiaobao(1);Yin, Qianqian(1);Jiang, Biao(1,7,8);2023;252; EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; 2023-04-05

  22. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Ren, Pengxuan(1);Yu, Changyue(2);Zhang, Ruxue(3);Nie, Tianqing(2,4);Hu, Qiaoyu(1,6);Li, Hui(2,4);Zhang, Xianglei(1);Zhang, Xueyuan(1);Li, Shiwei(1);Liu, Lu(1);Dai, Wenhao(2);Li, Jian(2);Xu, Yechun(2,4,5);Su, Haixia(2);Zhang, Leike(3);Liu, Hong(2,4,5);Bai, Fang(1,7,8); 2023;249; EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; 2023-03-05



2022

  1. Discovery and characterization of novel potent BCR-ABL degraders by conjugating allosteric inhibitor. Liu, Haixia(1,3,5);Mi, Qianglong(1,2);Ding, Xinyu(1,2,5);Lin, Chencen(1,3,5);Liu, Linyi(4);Ren, Chaowei(1,2,5);Shen, Shu Ting(1,2,5);Shao, Yu Bao(6);Chen, Jinju(1);Zhou, Yongqi(1);Ji, Liting(1);Zhang, Heqiao(1);Bai, Fang(1);Yang, Xiaobao(1,8);Yin, Qianqian(1);Jiang, Biao(1,7). 2022-12-15. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

  2. Structure of the NuA4 histone acetyltransferase complex. Liting Ji(1);Lixia Zhao(1);Ke Xu(1);Huihan Gao(1);Yang Zhou(1);Roger D. Kornberg(2);Heqiao Zhang(1). 2022.11. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

  3. Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin. Chen, Zhuozhi(1);Duan, Rongdi(1);Xiao, Yunjie(1);Wei, Yi(1);Zhang, Hanxiao(1);Sun, Xinzhao(1);Wang, Shen(1);Cheng, Yingying(1);Wang, Xue(1);Tong, Shanwei(1);Yao, Yunxiao(1);Zhu, Cheng(1);Yang, Haitao(1,2,3);Wang, Yanyan(1);Wang, Zefang(1,2). 2022-11-21. NATURE COMMUNICATIONS

  4. DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs. Li, Fenglei(1,2);Hu, Qiaoyu(1);Zhang, Xianglei(1);Sun, Renhong(3);Liu, Zhuanghua(2);Wu, Sanan(1);Tian, Siyuan(1,4);Ma, Xinyue(1,2);Dai, Zhizhuo(4);Yang, Xiaobao(3);Gao, Shenghua(2);Bai, Fang(1,2,4,5). 2022-11-21. NATURE COMMUNICATIONS

  5. A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Yan, Liming(1);Huang, Yucen(1,3);Ge, Ji(1,2);Liu, Zhenyu(1,4,5);Lu, Pengchi(6);Huang, Bo(7);Gao, Shan(1);Wang, Junbo(1);Tan, Liping(1);Ye, Sihan(1);Yu, Fengxi(3);Lan, Weiqi(4,5);Xu, Shiya(1);Zhou, Feng(7);Shi, Lei(7);Guddat, Luke W.(8);Gao, Yan(4,5);Rao, Zihe(1,2,4,5,9,10,11);Lou, Zhiyong(1). 2022-11-10. CELL

  6. Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir. Iketani, Sho(1,2);Mohri, Hiroshi(1,2);Culbertson, Bruce(3,4);Hong, Seo Jung(5);Duan, Yinkai(6,7);Luck, Maria, I(1,2);Annavajhala, Medini K.(2);Guo, Yicheng(1,2);Sheng, Zizhang(1,2);Uhlemann, Anne-Catrin(2);Goff, Stephen P.(1,8,9);Sabo, Yosef(1,2);Yang, Haitao(6,7);Chavez, Alejandro(5);Ho, David D.(1,2,8). 2022-11-09. NATURE

  7. Antigenic mapping reveals sites of vulnerability on alpha-HCoV spike protein. Xiang, Jiangchao(1,2,3);Su, Jie(1);Lan, Qiaoshuai(4);Zhao, Wenwen(1);Zhou, Yu(1);Xu, Youwei(1);Niu, Jun(1);Xia, Shuai(4);Qi, Qilian(1);Sidhu, Sachdev(5);Lu, Lu(4);Miersch, Shane(5);Yang, Bei(1,6). 2022-11-04. COMMUNICATIONS BIOLOGY

  8. PPI-Miner: A Structure and Sequence Motif Co-Driven Protein-Protein Interaction Mining and Modeling Computational Method. Wang, Lin(1);Li, Feng-lei(1);Ma, Xin-yue(1);Cang, Yong(2);Bai, Fang(1,3). 2022-11-01. JOURNAL OF CHEMICAL INFORMATION AND MODELING

  9. Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3. Hu, Tianyu(1,2,7,8);Yang, Xiaolin(1,2);Liu, Fengjiang(3);Sun, Shan(1,2);Xiong, Zhiqi(4);Liang, Jingxi(5);Yang, Xiaobao(1,2);Wang, Haofeng(1,2);Yang, Xiuna(1,2,9);Guddat, Luke W.(6);Yang, Haitao(1,2,9);Rao, Zihe(1,2,3,4,5,9);Zhang, Bing(1,2,9). 2022-10-06. STRUCTURE

  10. Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Han, Qi-lei(1);Zhang, Xiang-lei(2);Ren, Peng-xuan(2,3);Mei, Liang-he(4);Lin, Wei-hong(1);Wang, Lin(2,3);Cao, Yu(2,3);Li, Kai(1);Bai, Fang(2,3,5,6).2022-10.ACTA PHARMACOLOGICA SINICA

  11. PiLSL: pairwise interaction learning-based graph neural network for synthetic lethality prediction in human cancers. Liu, Xin(1);Yu, Jiale(1);Tao, Siyu(1);Yang, Beiyuan(1);Wang, Shike(1);Wang, Lin(2,3);Bai, Fang(1,2,3);Zheng, Jie(1,4). 2022-09-16. BIOINFORMATICS

  12. Metal-Free and Open-Air Arylation Reactions of Diaryliodonium Salts for DNA-Encoded Library Synthesis. Xu, Hongtao(1);Tan, Tingting(1);Zhang, Yiyuan(1);Wang, Yan(1);Pan, Kangyin(1);Yao, Ying(1);Zhang, Shuning(1);Gu, Yuang(1);Chen, Wanting(1);Li, Jie(1);Dong, Hewei(2);Meng, Yu(2);Ma, Peixiang(1,3);Hou, Wei(2);Yang, Guang(1). 2022-09-15. ADVANCED SCIENCE

  13. Construction of a Deep Neural Network Energy Function for Protein Physics. Yang, Huan(1);Xiong, Zhaoping(1);Zonta, Francesco(1). 2022-09-13. JOURNAL OF CHEMICAL THEORY AND COMPUTATION

  14. In Silico Maturation of a Nanomolar Antibody against the Human CXCR2. Buratto, Damiano(1,2);Wan, Yue(1,3);Shi, Xiaojie(1);Yang, Guang(1);Zonta, Francesco(1). 2022-09. BIOMOLECULES

  15. Selenylation Chemistry Suitable for On-Plate Parallel and On-DNA Library Synthesis Enabling High-Throughput Medicinal Chemistry. Xu, Hongtao(1);Wang, Yan(1);Dong, Hewei(2,3);Zhang, Yiyuan(1);Gu, Yuang(1);Zhang, Shuning(1);Meng, Yu(2,3);Li, Jie(1);Shi, Xiao Jie(1);Ji, Qun(1);Liu, Lili(1);Ma, Peixiang(1,4,5);Ma, Fei(1);Yang, Guang(1);Hou, Wei(2,3). 2022-08-26. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

  16. Reactive oxygen species-responsive Pre-PROTAC for tumor-specific protein degradation.  Liu, Haixia(1,2);Ren, Chaowei(1,3);Sun, Renhong(1);Wang, Huihui(1,3);Zhan, Yuexiong(1);Yang, Xiaobao(1,4);Jiang, Biao(1,2,3,5);Chen, Hongli(1). 2022-08-12. CHEMICAL COMMUNICATIONS

  17. Discovery and characterization of novel potent BCR-ABL degraders by conjugating allosteric inhibitor. Liu, Haixia(1,3,5);Mi, Qianglong(1,2);Ding, xinyu(1,2,5);Lin, Chencen(1,3,5);Liu, Linyi(4);Ren, Chaowei(1,2,5);Shen, Shuting(1,2,5);Shao, Yubao(6);Chen, jinju(1);Zhou, yongqi(1);Ji, Liting(1);Zhang, Heqiao(1);Bai, Fang(1);Yang, Xiaobao(1,8);Yin, Qianqian(1);Jiang, Biao(1,7). 2022-08-04. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

  18. A history of the origin and development of Japanese Society for Neurochemistry and international cooperation and contribution. Mikoshiba, Katsuhiko(1,2). 2022-08-01. JOURNAL OF NEUROCHEMISTRY

  19. A Small Molecule Selected from a DNA-Encoded Library of Natural Products That Binds to TNF-alpha and Attenuates Inflammation In Vivo. Wang, Shuyue(1,2,3,4);Shi, Xiaojie(1);Li, Jie(1);Huang, Qianping(1,2,3,4);Ji, Qun(1);Yao, Ying(1,2,3,4);Wang, Tao(1,2,3,4);Liu, Lili(1);Ye, Min(5);Deng, Yun(6);Ma, Peixiang(1,7);Xu, Hongtao(1);Yang, Guang(1). 2022-07-25. ADVANCED SCIENCE

  20. Micropillar-based phenotypic screening platform uncovers involvement of HDAC2 in nuclear deformability. Martewicz, Sebastian(1);Zhu, Xi(1,2);Qu, Siqi(1,2);Cui, Meihua(1);Grespan, Eleonora(3);Luni, Camilla(4);Jiang, Biao(1);Yang, Guang(1);Elvassore, Nicola(1,5,6,7). 2022-07. BIOMATERIALS

  21. Structures of Omicron Spike complexes and implications for neutralizing antibody development. Hangtian Guo(1,2);Yan Gao(2,3);Tinghan Li(1);Tingting Li(4,5);Yuchi Lu(6);Le Zheng(1);Yue Liu(1);Tingting Yang(1);Feiyang Luo(4,5);Shuyi Song(4,5);Wei Wang(6);Xiuna Yang(2,3);Henry C. Nguyen(7);Hongkai Zhang(2,8);Ailong Huang(9);Aishun Jin(4,5);Haitao Yang(2,3);Zihe Rao(2,10);Xiaoyun Ji(1,6). 2022-05-03. CELL REPORTS

  22. Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Yao Zhao(1,2);Yan Zhu(1,2,3);Xiang Liu(4,5);Zhenming Jin(1,2);Yinkai Duan(1,2);Qi Zhang(1,2);Chengyao Wu(1,2);Lu Feng(1,2);Xiaoyu Du(1,2);Jinyi Zhao(1,2);Maolin Shao(1,2);Bing Zhang(1,2);Xiuna Yang(1,2);Lijie Wu(6);Xiaoyun Ji(7);Luke W. Guddat(8);Kailin Yang(9);Zihe Rao(1,2,4,5,10,11);Haitao Yang(1,2,12). 2022-04-19. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

  23. A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1. Yang, Yifeng(1);Lu, Wenwen(2);Ning, Mei(3,4);Zhou, Xianhao(1);Wan, Xinyao(1);Mi, Qianglong(1);Yang, Xiaoyan(2);Zhang, Di(3,4);Zhang, Yuanyuan(1);Jiang, Biao(1);He, Lin(3,4);Liu, Jia(1,2,5);Zou, Yan(2). 2022-04-04. COMMUNICATIONS BIOLOGY

  24. Recent advances in predicting protein–protein interactions with the aid of artificial intelligence algorithms. Li, Shiwei(1,2);Wu, Sanan(1,2);Wang, Lin(1,2);Li, Fenglei(1,2,3);Jiang, Hualiang(1,2,4);Bai, Fang(1,2,3). 2022-04. CURRENT OPINION IN STRUCTURAL BIOLOGY

  25. Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein. Wang, Lin(1,2);Wu, Yan(3);Yao, Sheng(4,5);Ge, Huan(6);Zhu, Ya(7);Chen, Kun(7);Chen, Wen-zhang(1);Zhang, Yi(1);Zhu, Wei(1);Wang, Hong-yang(2);Guo, Yu(8,9);Ma, Pei-xiang(1);Ren, Peng-xuan(1,2);Zhang, Xiang-lei(1,2);Li, Hui-qiong(1,2);Ali, Mohammad A.(10);Xu, Wen-qing(2);Jiang, Hua-liang(1,7);Zhang, Lei-ke(3);Zhu, Li-li(2,6);Ye, Yang(4,5);Shang, Wei-juan(3);Bai, Fang(1,2). 2022-04. ACTA PHARMACOLOGICA SINICA

  26. PUMILIO proteins promote colorectal cancer growth via suppressing p21. Gong, Yuanyuan(1,2,3);Liu, Zukai(1);Yuan, Yihang(4);Yang, Zhenzhen(1);Zhang, Jiawei(1);Lu, Qin(4);Wang, Wei(1);Fang, Chao(4,5);Lin, Haifan(6);Liu, Sanhong(1,7). 2022-03-25. NATURE COMMUNICATIONS

  27. Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue. Wang, Haofeng(1,2,3,4);Xiao, Yunjie(1,2,3,4,5);Chen, Xia(1);Zhang, Mengwen(6,7);Sun, Guangxin(6);Wang, Feng(1);Wang, Lin(2,3,4);Zhang, Hanxiao(1);Zhang, Xiaoyu(1,8,9);Yang, Xin(5);Li, Wenling(1);Wei, Yi(1);Yao, Deqiang(10);Zhang, Bing(2,3);Li, Jun(2,3);Cui, Wen(1,5);Wang, Fenghua(1);Chen, Cheng(1);Shen, Wei(2,3,4);Su, Dan(11,12,13);Bai, Fang(2,3,4);Huang, Jinhai(1);Ye, Sheng(1);Zhang, Lei(1);Ji, Xiaoyun(14);Wang, Wei(5);Wang, Zefang(1,9);Hochstrasser, Mark(6);Yang, Haitao(1,2,3,4,9). 2022-03-25. NATURE COMMUNICATIONS

  28. KPT330 improves Cas9 precision genome- and base-editing by selectively regulating mRNA nuclear export. Cui, Yan ru(1);Wang, Shao jie(1);Ma, Tiancheng(2);Yu, Peihong(1,3);Chen, Jun(4);Guo, Taijie(2);Meng, Genyi(2);Jiang, Biao(1);Dong, Jiajia(2);Liu, Jia(1,5,6,7). 2022-03-17. COMMUNICATIONS BIOLOGY

  29. Probing the Allosteric Inhibition Mechanism of a Spike Protein Using Molecular Dynamics Simulations and Active Compound Identifications. Wang, Qian(4,5);Wang, Lin(1,2);Zhang, Yumin(3);Zhang, XiangLei(1,2);Zhang, Leike(3);Shang, Weijuan(3);Bai, Fang(1,2). 2022-02-24. JOURNAL OF MEDICINAL CHEMISTRY

  30. Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index. Wei, Xuan(1);Li, Lu(1);Wu, Yiwen(2);Liu, Jia(1,3). 2022-02-11. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

  31. Metal-Catalyzed One-Pot On-DNA Syntheses of Diarylmethane and Thioether Derivatives. Ma, Fei(1,2);Li, Jie(1);Zhang, Shuning(1);Gu, Yuang(1);Tan, Tingting(1);Chen, Wanting(1);Wang, Shuyue(1);Xu, Hongtao(1);Yang, Guang(1);Lerner, Richard A.(3). 2022-02-04. ACS CATALYSIS

  32. A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors. Ren, Peng-xuan(1,2);Shang, Wei-juan(3);Yin, Wan-chao(4);Ge, Huan(5);Wang, Lin(1,2);Zhang, Xiang-lei(1,2);Li, Bing-qian(1,2,6);Li, Hong-lin(5);Xu, Ye-chun(4,7);Xu, Eric H.(4,7);Jiang, Hua-liang(1,2,4,7);Zhu, Li-li(5);Zhang, Lei-ke(3);Bai, Fang(1,2). 2022-02. ACTA PHARMACOLOGICA SINICA

  33. Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago. Qiang, Min(1);Ma, Peixiang(1);Li, Yu(1,2,3,4);Liu, Hejun(5);Harding, Adam(6);Min, Chenyu(7);Wang, Fulian(1,2,3,4);Liu, Lili(1);Yuan, Meng(5);Ji, Qun(1);Tao, Pingdong(1,2,3,4);Shi, Xiaojie(1);Li, Zhean(1);Li, Teng(1,2,3,4);Wang, Xian(1,2,3,4);Zhang, Yu(2);Wu, Nicholas C.(5);Lee, Chang-Chun D.(5);Zhu, Xueyong(5);Gilbert-Jaramillo, Javier(6);Zhang, Chuyue(1,2,3,4);Saxena, Abhishek(1);Huang, Xingxu(2);Wang, Hou(8);James, William(6);Dwek, Raymond A.(9);Wilson, Ian A.(5,10);Yang, Guang(1,7);Lerner, Richard A.(11). 2022-01-05. ADVANCED SCIENCE

  34. IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors. Zou, Yan(1);Liu, Bo(2,3);Li, Long(1);Yin, Qinan(4);Tang, Jiaxing(1);Jing, Zhengyu(2,3);Huang, Xingxu(2);Zhu, Xuekai(1);Chi, Tian(2,5). 2022.1. CANCER LETTERS



2021

  1. Structural biology of SARS-CoV-2 and implications for therapeutic development. Haitao Yang(1);Zihe Rao(1,2,3,4). 2021-11. NATURE REVIEWS MICROBIOLOGY 10.1038/s41579-021-00630-8

  2. High-throughput screening identifies   established drugs as SARS-CoV-2 PLpro inhibitors. Zhao, Yao(1,2);Du, Xiaoyu(3,4);Duan, Yinkai(1,2);Pan, Xiaoyan(5);Sun, Yifang(6,7);You, Tian(1,2);Han, Lin(6,7);Jin, Zhenming(1,2,3,4);Shang, Weijuan(5);Yu, Jing(1,2);Guo, Hangtian(1,2);Liu, Qianying(6,7);Wu, Yan(5);Peng, Chao(8);Wang, Jun(1,2);Zhu, Chenghao(1,2);Yang, Xiuna(1,2);Yang, Kailin(9);Lei, Ying(1,2);Guddat, Luke W.(10);Xu, Wenqing(1,2,8);Xiao, Gengfu(5);Sun, Lei(6,7);Zhang, Leike(5);Rao, Zihe(1,2,3,4);Yang, Haitao(1,2). 2021-11. PROTEIN & CELL 10.1007/s13238-021-00836-9

  3. Rapid Assessment of Binding Affinity of   SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2  Receptor and to Neutralizing Biomolecules Based on Computer Simulations. Buratto, Damiano(1);Saxena, Abhishek(1);Ji, Qun(1);Yang, Guang(1);Pantano,  Sergio(1,2);Zonta, Francesco(1). 2021-11-11. FRONTIERS IN IMMUNOLOGY 10.3389/fimmu.2021.730099

  4. Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation. Liu HX(1,3,5);Ding XY(1,3,5);Liu LY(4);Mi QL(1,2);Zhao QJ(1);Shao YB(6);Ren CW(1,2);Chen JJ(1);Kong Y(1);Chou X(7);Elvassore Nicola(1);Yang XB(1);Yin QQ(1);Jiang B(1,7). 2021-11-05. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 10.1016/j.ejmech.2021.113645

  5. Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist. Mei, Hong(1,2);Zha, Zhao(1,2);Wang, Wei(1,2);Xie, Yusang(3,4);Huang, Yuege(1,2,5);Li, Wenping(1,2,5);Wei, Dong(6);Zhang, Xinxin(6);Qu, Jieming(3,4);Liu, Jia(1,2,7,8,9,10). 2021-10-22. GENOME BIOLOGY 10.1186/s13059-021-02513-w

  6. Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332. Zhao, Yao(1,2);Fang, Chao(3);Zhang, Qi(1,2,4,5);Zhang, Ruxue(6);Zhao, Xiangbo(3);Duan, Yinkai(1,2);Wang, Haofeng(1,2);Zhu, Yan(1,2);Feng, Lu(1,2);Zhao, Jinyi(1,2);Shao, Maolin(1,2);Yang, Xiuna(1,2);Zhang, Leike(6);Peng, Chao(7);Yang, Kailin(8);Ma, Dawei(3);Rao, Zihe(1,2,9,10,11);Yang, Haitao(1,2). 2021.  PROTEIN & CELL 10.1007/s13238-021-00883-2

  7. Structural and mechanistic insights into the complexes formed by Wolbachia cytoplasmic incompatibility factors. Xiao, Yunjie(1,2,3);Chen, Hongli(4);Wang, Haofeng(1,2,3,5);Zhang, Mengwen(4,6);Chen, Xia(1);Berk, Jason M.(4);Zhang, Lilin(1);Wei, Yi(1);Li, Wenling(1);Cui, Wen(1,5);Wang, Fenghua(1);Wang, Qianfan(1);Cui, Can(1);Li, Ting(1);Chen, Cheng(1);Ye, Sheng(1);Zhang, Lei(1);Ji, Xiaoyun(5,7);Huang, Jinhai(1);Wang, Wei(5);Wang, Zefang(1,8);Hochstrasser, Mark(4);Yang, Haitao(1,2,3,8). 2021-10-12. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 10.1073/pnas.2107699118

  8. Two novel strategies to overcome the resistance to ALK tyrosine kinase inhibitor drugs: Macrocyclic inhibitors and proteolysis‐targeting chimeras. Xiaoling Song(1);Hui Zhong(1,2);Xiaojuan Qu(1);Linsong Yang(2);Biao Jiang(1,3). 2021-09. MEDCOMM 10.1002/mco2.42

  9. Accurate Retention Time Prediction Based on Monolinked Peptide Information to Confidently Identify Cross-Linked Peptides. Huang, Rong(1,2);Zhu, Wei(1);Xu, Zili(1);Chen, Jiakang(1);Jiang, Biao(1);Chen, Hongli(1);Chen, Wenzhang(1). 2021-09-01. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 10.1021/jasms.1c00120

  10. Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels. Wang, Weiwei(1,2,3,4,5);Gao, Yan(1,2);Tang, Yanting(3);Zhou, Xiaoting(1,2,4,5);Lai, Yuezheng(3);Zhou, Shan(3);Zhang, Yuying(3);Yang, Xiuna(1,2);Liu, Fengjiang(1,2,4,5);Guddat, Luke W.(6);Wang, Quan(1,2);Rao, Zihe(1,2,3,7,8);Gong, Hongri(3). 2021-07-30. NATURE COMMUNICATIONS 10.1038/s41467-021-24924-w

  11. Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein. Li, Bingqian(1,2,3);Wang, Lin(1,2);Ge, Huan(4);Zhang, Xianglei(1,2);Ren, Penxuan(1,2);Guo, Yu(5,6);Chen, Wuyan(7);Li, Jie(7);Zhu, Wei(1,2);Chen, Wenzhang(1,2);Zhu, Lili(4);Bai, Fang(1,2). 2021-07-22. FRONTIERS IN   CHEMISTRY 10.3389/fchem.2021.659764

  12. Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile. Ren, Chaowei(1,2,3);Sun, Ning(1,4,5);Liu, Haixia(1,3,6);Kong, Ying(5,7);Sun, Renhong(1,4);Qiu, Xing(8);Chen, Jinju(7);Li, Yan(7);Zhang, Jianshui(7);Zhou, Yuedong(7);Zhong, Hui(1,9);Yin, Qianqian(1);Song, Xiaoling(1);Yang, Xiaobao(1);Jiang, Biao(1,6,8).2021-07-08.JOURNAL OF MEDICINAL CHEMISTRY 10.1021/acs.jmedchem.1c00373

  13. Coupling of N7-methyltransferase and 3'-5 ' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Yan, Liming(1,2,3);Yang, Yunxiang(1,5);Li, Mingyu(1);Zhang, Ying(1);Zheng, Litao(2,3,4);Ge, Ji(4);Huang, Yucen C.(1);Liu,   Zhenyu(1);Wang, Tao(1,2,3);Gao, Shan(1);Zhang, Ran(4);Huang, Yuanyun Y.(6);Guddat, Luke W.(7);Gao, Yan(2,3);Rao, Zihe(1,2,3,4,8,9,10,11);Lou, Zhiyong(1,11). 2021-06-24. CELL 10.1016/j.cell.2021.05.033

  14. Effective degradation of EGFR(L858R+T790M) mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems. Qu, Xiaojuan(1,2,6);Liu, Haixia(1,3,6);Song, Xiaoling(1);Sun, Ning(1);Zhong, Hui(1,4);Qiu, Xing(1,5);Yang, Xiaobao(1);Jiang, Biao(1,5). 2021-06-05. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 10.1016/j.ejmech.2021.113328

  15. Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M-pro. Wang, Zhengyuan(1);Zhao, Yao(2,3);Wang, Qingxing(4);Xing, Yangfei;Feng, Lu(2,3);Kong, Juan(2,3);Peng, Chao(5);Zhang, Leike(4);Yang, Haitao(2,3);Lu, Min(1). 2021-06-01. SIGNAL TRANSDUCTION AND TARGETED THERAPY 10.1038/s41392-021-00639-8

  16. Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations. Wang, Lijie(1,2,3,4);Xue, Wei(5);Zhang, Hongxia(6,7);Gao, Runze(1,2,3,4);Qiu, Houyuan(6,7);Wei, Jia(5);Zhou, Lina(1,2,3,4);Lei, Yun-Ni(1,5);Wu, Xiaocheng(6,7);Li, Xiao(8);Liu, Chengfang(1,2,3,4);Wu, Jing(1,2);Chen, Qiubing(6,7);Ma, Hanhui(1,2);Huang, Xingxu(1,2,3);Cai, Cheguo(8);Zhang, Ying(9);Yang, Bei(1);Yin, Hao(6,7);Yang, Li(5);Chen, Jia(1,2,3). 2021-05. NATURE CELL BIOLOGY 10.1038/s41556-021-00671-4

  17. Palladium-catalyzed one-pot phosphorylation of phenols mediated by sulfuryl fluoride dagger. Zhang, Yiyuan(1,2,3,4);Chen, Wanting(1,2,3,4);Tan, Tingting(1,2,3,4);Gu, Yuang(1,2,3,4);Zhang, Shuning(1,2,3,4);Li, Jie(1);Wang, Yan(1,2,3,4);Hou, Wei(5,6);Yang, Guang(1);Ma, Peixiang(1);Xu, Hongtao(1). 2021-05-07. CHEMICAL   COMMUNICATIONS 10.1039/d1cc00769f

  18. Selection of a picomolar antibody that  targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms. Xiaojie Shi(1);Yue Wan(1,2,3,4);Nan Wang(1,2,3,4);Jiangchao   Xiang(1,2,3,4);Tao Wang(1,2,3);Xiaofeng Yang(1);Ju Wang(1);Xuxue Dong(1,2,3);Liang Dong(1,2);Lei Yan(1);Yu Li(1,2,3);Lili Liu(1);Shinchen Hou(1);Zhenwei Zhong(1);Ian A. Wilson(6,7);Bei Yang(1);Guang Yang(1);Richard A. Lerner(1,5). 2021-05-05. NATURE COMMUNICATIONS 10.1038/s41467-021-22810-z

  19. Structure-based discovery of SIAIS001 as an oral bioavailability ALK degrader constructed from Alectinib. Ren, Chaowei(1,2,3);Sun, Ning(1);Kong, Ying(7);Qu, Xiaojuan(1,2,3);Liu, Haixia(1,4);Zhong, Hui(1,6);Song, Xiaoling(1);Yang, Xiaobao(1);Jiang, Biao(1,5). 2021-05-05. EUROPEAN JOURNAL OF MEDICINAL   CHEMISTRY 10.1016/j.ejmech.2021.113335

  20. Combretastatin A4-derived payloads for antibody-drug conjugates. Huang Rong(1,2);Shen, Yao(1);Xu, Zili(1,2);Wei, Ding(1,2,3);Song, Xiaoling(1);Jiang, Biao(1);Chen, Hongli(1). 2021-04-15. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 10.1016/j.ejmech.2021.113355

  21. Mediator structure and conformation change. Zhang, Heqiao(1,2);Chen, Dong-Hua(2);Mattoo, Rayees U. H.(2);Bushnell, David A.(2);Wang, Yannan(1);Yuan, Chao(1);Wang, Lin(1);Wang, Chunnian(1);Davis, Ralph E.(2);Nie, Yan(1);Kornberg, Roger D.(1,2). 2021-04-15. MOLECULAR CELL 10.1016/j.molcel.2021.01.022

  22. Structural basis for GTP-induced dimerization and antiviral functioin of guanylate-binding proteins. Cui, Wen(1,2,3);Braun, Elisabeth(4);Wang, Wei(3);Tang, Jinhong(1);Zheng, Yanyan(5);Slater, Benjamin(6);Li, Na(7);Chen, Cheng(1);Liu, Qingxiang(5);Wang, Bin(1);Li,Xiu(1);Duan, Yinkai(2);Xiao, Yunjie(1);Ti, Rujiao(1);Hotter, Dominik(4);Ji, Xiaoyun(3,8);Zhang, Lei(1);Cui, Jun(5);Xiong, Yong(6);Sauter, Daniel(4,9);Wang, Zefang(1,10);Kirchhoff, Frank(4);Yang, Haitao(1,2,10). 2021-04-13. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 10.1073/pnas.2022269118

  23. Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors. Lin, Tingting(1,2,3,4,5);Li, Jiacheng(3,5);Liu, Liping(3,5);Li, Yuanqing(3,5);Jiang, Hualiang(1,2,3,5);Chen, Kaixian(1,2,3,5);Xu, Pan(3);Luo, Cheng(1,2,3,5);Zhou, Bing(4,5). 2021-04-05. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 10.1016/j.ejmech.2021.113281

  24. Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster. Zhou, Xiaoting;Gao, Yan;Wang, Weiwei;Yang, Xiaolin;Yang, Xiuna;Liu, Fengjiang;Tang, Yanting;Lam, Sin Man;Shui, Guanghou;Yu, Lu;Tian, Changlin;Guddat, Luke W.;Wang, Quan;Rao, Zihe;Gong, Hongri. 2021-04-05. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 10.1073/pnas.2022308118

  25. Development of a Broadly Applicable Cas12a-Linked Beam Unlocking Reaction for Sensitive and Specific Detection of Respiratory Pathogens Including SARS-CoV-2. Wang, Yu(1,2);Liu, Donglan(3);Lin, Huihuang(4,5);Chen, Dingbin(3);Sun, Jing(3);Xie, Yusang(4,5);Wang, Xinjie(1);Ma, Peixiang(1);Nie, Yan(1);Mei, Hong(1);Zhao, Baihui(6);Huang, Xingxu(7);Jiang, Ge(1);Jiang, Xianxing(2);Qu, Jieming(4,5);Zhao, Jincun(3);Liu, Jia(1,3,7). 2021-03-19. ACS CHEMICAL  BIOLOGY 10.1021/acschembio.0c00840

  26. Antivirals with common targets against highly pathogenic viruses. Lu Lu;Su Shan;Yang Haitao;Jiang Shibo. 2021-03-18. CELL 10.1016/j.cell.2021.02.013

  27. Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis. Zheng, Qinheng(1);Xu, Hongtao(2);Wang, Hua(1,3);Du, Wen-Ge Han(4);Wang, Nan(2);Xiong, Huan(2);Gu, Yuang(2);Noodleman, Louis(4);Sharpless, K. Barry(1);Yang, Guang(2);Wu, Peng(3). 2021-03-17. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 10.1021/jacs.0c09306

  28. BAY 60-6583 Enhances the Antitumor Function of Chimeric Antigen Receptor-Modified T Cells Independent of the Adenosine A2b Receptor. Tang, Jiaxing(1,2,3,4);Zou, Yan(1);Li, Long(1);Lu, Fengping(1);Xu, Hongtao(1);Ren, Pengxuan(1);Bai, Fang(1);Niedermann, Gabriele(5,6,7);Zhu, Xuekai(1). 2021-03-12. FRONTIERS IN PHARMACOLOGY 10.3389/fphar.2021.619800

  29. Avidity-Based Selection of Tissue-Specific CAR-T Cells from a Combinatorial Cellular Library of CARs. Ma, Peixiang(1);Ren, Ping(1);Zhang, Chuyue(1,2,3,4);Tang, Jiaxing(1,2,3,4);Yu, Zheng(1);Zhu, Xuekai(1);Fan, Kun(1,2,3,4);Li, Guanglei(2);Zhu, Wei(1);Sang, Wei(5);Min, Chenyu(6);Chen, Wenzhang(1);Huang, Xingxu(2);Yang, Guang(1);Lerner, Richard A.(7). 2021-03. ADVANCED   SCIENCE 10.1002/advs.202003091

  30. gem-Difluoromethylene Alkyne-Enabled Diverse C-H Functionalization and Application to the on-DNA Synthesis of Difluorinated Isocoumarins. Gao, Hui(3,4,5);Lin, Shuang(3,4,5);Zhang, Shuning(1,2);Chen, Weijie(3,4,5);Liu, Xiamen(3,4,5);Yang, Guang(1);Richard A. Lerner(6);Xu, Hongtao(1);Zhou, Zhi(3,4,5);Yi, Wei(3,4,5). 2021-01-25. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 10.1002/anie.202013052

  31. Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations. He, Di(1,2);Wang, Di(2);Lu, Ping(3);Yang, Nan(4);Xue, Zhigang(3);Zhu, Xianmin(1,2);Zhang, Peng(2);Fan, Guoping(1,5). 2021-01-14. ONCOGENE 10.1038/s41388-020-01528-0

  32. Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs. Wang, Chen(1);Lin,   Haifan(2,3). 2021-01-08. GENOME BIOLOGY 10.1186/s13059-020-02221-x

  33. Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Yan, Liming(1);Ge, Ji(2);Zheng, Litao(2);Zhang, Ying(1);Gao, Yan(1,3);Wang, Tao(1);Huang, Yucen(1);Yang, Yunxiang(1);Gao, Shan(1);Li, Mingyu(1);Liu, Zhenyu(1);Wang, Haofeng(3);Li, Yingjian(4);Chen, Yu(4);Guddat, Luke W.(5);Wang, Quan(3);Rao, Zihe(1,2,3);Lou, Zhiyong(1). 2021-01-07. CELL 10.1016/j.cell.2020.11.016

 


2020

  1. Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. Liu, Fengjiang(1,2,3);Liang, Jingxi(4);Zhang, Bing(1);Gao, Yan(1,5);Yang, Xiuna(1);Hu, Tianyu(1);Yang, Haitao(1);Xu, Wenqing(1);Guddat, Luke W.(6);Rao, Zihe(1,4,5,7). SCIENCE ADVANCES. 2020. DOI:. 10.1126/sciadv.abb9833

  2. Divinylsulfonamides enable the construction of homogeneous antibody–drug conjugates. Rong Huang(1,2);Yao Sheng(1);Ding Wei(1,2,3);Wenwen Lu(1,2);Hongli Chen(1);Biao Jiang(1). BIOORGANIC & MEDICINAL CHEMISTRY. 2020. DOI:. 10.1016/j.bmc.2020.115793

  3. Decision tree searching strategy to boost the identification of cross-linked peptides.. Huang, Rong(1,2);Gao, Xiuxia(1);Xu, Zili(1);Zhu, Wei(1);Wei, Ding(1,2);Jiang, Biao(1);Chen, Hongli(1);Chen, Wenzhang(1). ANALYTICAL CHEMISTRY. 2020. DOI:. 10.1021/acs.analchem.0c00452

  4. MeCas12a, a Highly Sensitive and Specific System for COVID-19 Detection. Ma, Peixiang(1);Meng, Qingzhou(2);Sun, Baoqing(3);Zhao, Bing(4);Dang, Lu(2);Zhong, Mingtian(5);Liu, Siyuan(6);Xu, Hongtao(1);Mei, Hong(1);Liu, Jia(1);Chi, Tian(6);Yang, Guang(1);Liu, Ming(3);Huang, Xingxu(6);Wang, Xinjie(1). ADVANCED SCIENCE. 2020. DOI:. 10.1002/advs.202001300

  5. Parabrachial neuron types categorically encode thermoregulation variables during heat defense. Wen Z. Yang(1,2,3);Xiaosa Du(1,2,4,5);Wen Zhang(4);Cuicui Gao(1,2,4,5);Hengchang Xie(1,2,4,5);Yan Xiao(6,7);Xiaoning Jia(1,2);Jiashu Liu(1,2);Jianhui Xu(8);Xin Fu(1,2,4,5);Hongqing Tu(1,2,4,5);Xiaoyu Fu(1,2,4,5);Xinyan Ni(1,2);Miao He(9);Jiajun Yang(6,7);Hong Wang(10);Haitao Yang(1,2);Xiao-hong Xu(4);Wei L. Shen(1,2). SCIENCE ADVANCES. 2020. DOI:. 10.1126/sciadv.abb9414

  6. PIWIL1 promotes gastric cancer via a piRNA-independent mechanism. Shi, Shuo(1);Yang, Zhen-Zhen(1);Liu, Sanhong(1);Yang, Fan(1);Lin, Haifan(2,3). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. DOI:. 10.1073/pnas.2008724117

  7. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo. Tao, Pingdong(1,2,3,4);Kuang, Yuanyuan(1,2,3,4);Li, Yu(1,2,3,4);Li, Wenping(1,2,3,4);Gao, Zibei(2);Liu, Lili(1);Qiang, Min(1);Zha, Zhao(1);Fan, Kun(1,2,3,4);Ma, Peixiang(1);Friedman, Jeffrey M.(5);Yang, Guang(1);Lerner, Richard A.(6). ADVANCED SCIENCE. 2020. DOI:. 10.1002/advs.202000818

  8. A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice. Kuang, Yuanyua(1,2,3,4);Zorzi, Veronica(5,6);Buratto, Damiano(1);Ziraldo, Gaia(5,6);Mazzarda, Flavia(5,7);Peres, Chiara(5,8);Nardin, Chiara(5,8);Salvatore, Anna Maria(5);Chiani, Francesco(5);Scavizzi, Ferdinando(5);Raspa, Marcello(5);Qiang, Min(1);Chu, Youjun(1);Shi, Xiaojie(1);Li, Yu(1,2,3,4);Liu, Lili(1);Shi, Yaru(1);Zonta, Francesco(1);Yang, Guang(1);Lerner, Richard A.(1,9);Mammano, Fabio(1,5,8). EBIOMEDICINE. 2020. DOI:. 10.1016/j.ebiom.2020.102825

  9. Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO. Yang, Xiaolin(1,2,3,8);Hu, Tianyu(1,2);Yang, Xiuna(1,2);Xu, Wenqing(1,2);Yang, Haitao(1,2);Guddat, Luke W.(7);Zhang, Bing(1,2);Rao, Zihe(1,2,4,5,6). JOURNAL OF MOLECULAR BIOLOGY. 2020. DOI:. 10.1016/j.jmb.2020.05.019

  10. Inhibitory antibodies identify unique sites of therapeutic vulnerability in rhinovirus and other enteroviruses. Meng, Bing(1);Lan, Keke(1,2);Xie, Jia(3);Lerner, Richard A.(3);Wilson, Ian A.(1,4,5);Yang, Bei(1). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. DOI:. 10.1073/pnas.1918844117

  11. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Wang, Quan(1,2);Wu, Jiqin(3);Wang, Haofeng(1,2,4);Gao, Yan(5);Liu, Qiaojie(3);Mu, An(6,7);Ji, Wenxin(6,7);Yan, Liming(5);Zhu, Yan(1,2);Zhu, Chen(1,2);Fang, Xiang(3,6);Yang, Xiaobao(1,2);Huang, Yucen(5);Gao, Hailong(6,7);Liu, Fengjiang(1,2);Ge, Ji(5);Sun, Qianqian(1,2);Yang, Xiuna(1,2);Xu, Wenqing(1,2);Liu, Zhijie(1,2);Yang, Haitao(1,2);Lou, Zhiyong(5);Jiang, Biao(1,2);Guddat, Luke W.(8);Gong, Peng(3);Rao, Zihe(1,2,5,7). CELL. 2020. DOI:. 10.1016/j.cell.2020.05.034

  12. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Jin, Zhenming(1,2,3,4);Zhao, Yao(1,2);Sun, Yuan(5);Zhang, Bing(1,2);Wang, Haofeng(1,2,6);Wu, Yan(5);Zhu, Yan(1,2);Zhu, Chen(1,2);Hu, Tianyu(1,2);Du, Xiaoyu(1,2,3,4);Duan, Yinkai(1,2);Yu, Jing(1,2);Yang, Xiaobao(1,2);Yang, Xiuna(1,2);Yang, Kailin(7);Liu, Xiang(8);Guddat, Luke W.(9);Xiao, Gengfu(5);Zhang, Leike(5);Yang, Haitao(1,2);Rao, Zihe(1,2,3,4,8). NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2020. DOI:. 10.1038/s41594-020-0440-6

  13. Rapid and sensitive detection of COVID-19 using CRISPR/Cas12a-based detection with naked eye readout, CRISPR/Cas12a-NER. Wang, Xinjie(1);Zhong, Mingtian(2);Liu, Yong(3,4);Ma, Peixiang(1);Dang, Lu(5);Meng, Qingzhou(5);Wan, Wenwei(6);Ma, Xiaodong(2);Liu, Jia(1);Yang, Guang(1);Yang, Zifeng(3);Huang, Xingxu(6);Liu, Ming(3). SCIENCE BULLETIN. 2020. DOI:. 10.1016/j.scib.2020.04.041

  14. A DNA-encoded library for the identification of natural product binders that modulate poly (ADP-ribose) polymerase 1, a validated anti-cancer target. Li, Jie(1,2,3,4);Li, Yu(1,2,3,4);Lu, Fengping(1);Liu, Lili(1);Ji, Qun(1);Song, Ke(1);Yin, Qianqian(1);Lerner, Richard A.(5);Yang, Guang(1);Xu, Hongtao(1);Ma, Peixiang(1). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020. DOI:. 10.1016/j.bbrc.2020.04.022

  15. Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer. Chen, Xi(1);Wang, Chen(1,2);Jiang, Yuhang(1,3);Wang, Qi(1);Tao, Yu(1,3);Zhang, Haohao(1,3);Zhao, Yongxu(1);Hu, Yiming(1,3);Li, Cuifeng(1,3);Ye, Deji(1);Liu, Dandan(1);Jiang, Wenxia(1);Chin, Eugene Y.(1);Chen, Sheng(4);Liu, Yongzhong(5);Wang, Mingliang(6);Liu, Sanhong(1,2);Zhang, Xiaoren(1,3). SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2020. DOI:. 10.1038/s41392-020-0138-6

  16. A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries. Xu, Hongtao(1);Gu, Yuang(1,4,5,6);Zhang, Shuning(1,4,5,6);Xiong, Huan(1);Ma, Fei(1);Lu, Fengping(1);Ji, Qun(1);Liu, Lili(1);Ma, Peixiang(1);Hou, Wei(2,3);Yang, Guang(1);Lerner, Richard A.(7). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020. DOI:. 10.1002/anie.202003595

  17. Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. Zhang, Lu(1,2,3,4);Zhao, Yao(1,2,3,5,6);Gao, Yan(7);Wu, Lijie(1,2,3);Gao, Ruogu(6,8,9);Zhang, Qi(1,2,3);Wang, Yinan(1,2,3,6);Wu, Chengyao(1,2,3);Wu, Fangyu(4);Gurcha, Sudagar S.(10);Veerapen, Natacha(10);Batt, Sarah M.(10);Zhao, Wei(4);Qin, Ling(1,2,3,12);Yang, Xiuna(1,2,3);Wang, Manfu(1,2,3);Zhu, Yan(1,2,3);Zhang, Bing(1,2,3);Bi, Lijun(8,9);Zhang, Xian'en(8,9);Yang, Haitao(1,2,3);Guddat, Luke W.(11);Xu, Wenqing(1,2,3);Wang, Quan(1,2,3,8,9);Li, Jun(1,2,3);Besra, Gurdyal S.(10);Rao, Zihe(1,2,3,4,7,8,9). SCIENCE. 2020. DOI:. 10.1126/science.aba9102

  18. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Dai, Wenhao(1,2);Zhang, Bing(3,4);Jiang, Xia-Ming(5);Su, Haixia(1,6);Li, Jian(1,6);Zhao, Yao(3,4);Xie, Xiong(1,6);Jin, Zhenming(3,4);Peng, Jingjing(1,6);Liu, Fengjiang(3,4);Li, Chunpu(1,6);Li, You(8);Bai, Fang(3,4);Wang, Haofeng(3,4);Cheng, Xi(1);Cen, Xiaobo(8);Hu, Shulei(1);Yang, Xiuna(3,4);Wang, Jiang(1,6);Liu, Xiang(9);Xiao, Gengfu(5);Jiang, Hualiang(1,3,4,6);Rao, Zihe(3,4);Zhang, Lei-Ke(5);Xu, Yechun(1,6);Yang, Haitao(3,4);Liu, Hong(1,6,7). SCIENCE. 2020. DOI:. 10.1126/science.abb4489

  19. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Gao, Yan(1,2,3,4);Yan, Liming(1,2);Huang, Yucen(1,2);Liu, Fengjiang(3,4);Zhao, Yao(3,4);Cao, Lin(5,6);Wang, Tao(1,2);Sun, Qianqian(3,4);Ming, Zhenhua(7);Zhang, Lianqi(1,2);Ge, Ji(1,2);Zheng, Litao(1,2);Zhang, Ying(1,2);Wang, Haofeng(3,4,8);Zhu, Yan(3,4);Zhu, Chen(3,4);Hu, Tianyu(3,4);Hua, Tian(3,4);Zhang, Bing(3,4);Yang, Xiuna(3,4);Li, Jun(3,4);Yang, Haitao(3,4);Liu, Zhijie(3,4);Xu, Wenqing(3,4);Guddat, Luke W.(9);Wang, Quan(3,4);Lou, Zhiyong(1,2);Rao, Zihe(1,2,3,4,5,6,10). SCIENCE. 2020. DOI:. 10.1126/science.abb7498

  20. Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors. Jin, Zhenming(1,2,3,4);Du, Xiaoyu(3,4);Xu, Yechun(5);Deng, Yongqiang(6);Liu, Meiqin(7);Zhao, Yao(1,2);Zhang, Bing(1,2);Li, Xiaofeng(6);Zhang, Leike(7);Peng, Chao(8);Duan, Yinkai(1,2);Yu, Jing(1,2);Wang, Lin(1,2);Yang, Kailin(9);Liu, Fengjiang(1,2);Jiang, Rendi(7);Yang, Xinglou(7);You, Tian(1,2);Liu, Xiaoce(1,2);Yang, Xiuna(1,2);Bai, Fang(1,2);Liu, Hong(5);Liu, Xiang(10);Guddat, Luke W.(11);Xu, Wenqing(1,2,8);Xiao, Gengfu(7);Qin, Chengfeng(6);Shi, Zhengli(7);Jiang, Hualiang(1,2,5);Rao, Zihe(1,2,3,4,10);Yang, Haitao(1,2). NATURE. 2020. DOI:. 10.1038/s41586-020-2223-y

  21. Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury. Dong, Yixiao(1,2,3);Cui, Meihua(1);Qu, Ju(1);Wang, Xuechun(1);Kwon, Sun Hyung(2);Barrera, Janos(2);Elvassore, Nicola(1);Gurtner, Geoffrey C.(2). ACTA BIOMATERIALIA. 2020. DOI:. 10.1016/j.actbio.2020.03.040

  22. Iridium-catalyzed C-H amidation of s-tetrazines. Xiong, Huan(1);Gu, Yuang(1,2,3,4);Zhang, Shuning(1,2,3,4);Lu, Fengping(1);Ji, Qun(1);Liu, Lili(1);Ma, Peixiang(1);Yang, Guang(1);Hou, Wei(5,6);Xu, Hongtao(1). CHEMICAL COMMUNICATIONS. 2020. DOI:. 10.1039/d0cc01647k

  23. Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis. Uyhazi, Katherine E.(1);Yang, Yiying(1,2,3);Liu, Na(1);Qi, Hongying(1);Huang, Xiao A.(1);Mak, Winifred(1,4);Weatherbee, Scott D.(5);de Prisco, Nicola(6,7,8);Gennarino, Vincenzo A.(6,7,8,9);Song, Xiaoling(2);Lin, Haifan(1,2,3,4,5). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. DOI:. 10.1073/pnas.1916471117

  24. Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance. Sun, Ning(1);Ren, Chaowei(1);Kong, Ying(5);Zhong, Hui(1,3);Chen, Jinju(5);Li, Yan(5);Zhang, Jianshui(5);Zhou, Yuedong(5);Qiu, Xing(2);Lin, Haifan(1,4);Song, Xiaoling(1);Yang, Xiaobao(1);Jiang, Biao(1,2). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2020. DOI:. 10.1016/j.ejmech.2020.112190

  25. Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides. Cui, Yan-ru(1,2,3,4);Wang, Shao-jie(1);Chen, Jun(5);Li, Jie(1,2,3,4);Chen, Wenzhang(1);Wang, Shuyue(1,2,3,4);Meng, Bing(1);Zhu, Wei(1);Zhang, Zhuhong(6);Yang, Bei(1);Jiang, Biao(1);Yang, Guang(1);Ma, Peixiang(1);Liu, Jia(1). GENOME BIOLOGY. 2020. DOI:. 10.1186/s13059-020-01956-x

  26. Bis(vinylsulfonyl)piperazines as efficient linkers for highly homogeneous antibody-drug conjugates. Huang, Rong(1,2);Sheng, Yao(1);Wei, Ding(1,2);Yu, Jianghui(1,2);Chen, Hongli(1);Jiang, Biao(1). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2020. DOI:. 10.1016/j.ejmech.2020.112080

  27. A Synthetic Human Antibody Antagonizes IL-18R beta Signaling Through an Allosteric Mechanism. Liu, Shusu(1);Miersch, Shane(2);Li, Ping(1,3);Bai, Bingxin(1);Liu, Chunchun(1);Qin, Wenming(4);Su, Jie(1);Huang, Haiming(2,5);Pan, James(2);Sidhu, Sachdev S.(1,2);Wu, Donghui(1). JOURNAL OF MOLECULAR BIOLOGY. 2020. DOI:. 10.1016/j.jmb.2020.01.012

  28. Host-mediated ubiquitination of a mycobacterial protein suppresses immunity. Wang, Lin(1);Wu, Juehui(1,2);Li, Jun(3,4);Yang, Hua(1);Tang, Tianqi(2);Liang, Haijiao(1,2);Zuo, Mianyong(2);Wang, Jie(1);Liu, Haipeng(1,5);Liu, Feng(1);Chen, Jianxia(1,5);Liu, Zhonghua(1);Wang, Yang(2);Peng, Cheng(2);Wu, Xiangyang(2);Zheng, Ruijuan(1);Huang, Xiaochen(1);Ran, Yajun(3,4);Rao, Zihe(3,4,6,7,8,9);Ge, Baoxue(1,2,5). NATURE. 2020. DOI:. 10.1038/s41586-019-1915-7

  29. IP3 Receptor Plasticity Underlying Diverse Functions. Hamada, Kozo(1);Mikoshiba, Katsuhiko(1). ANNUAL REVIEW OF PHYSIOLOGY. 2020. DOI:. 10.1146/annurev-physiol-021119-034433



2019

  1. Yang Zhang#, Xiaodan Sun#, Yangyang Qian, Hongfei Yi, Ke Song, Huanhu Zhu, Francesco Zonta, Weizhong Chen, Quanjiang Ji, Shane Miersch, Sachdev S Sidhu*, Donghui Wu*. A potent anti-SpuE antibody allosterically inhibits type III secretion system and attenuates virulence of Pseudomonas aeruginosa. Journal of Molecular Biology, Volume 431, Issue 24, 6 December 2019, Pages 4882-4896

  2. Wang S#, Zhou K, Yang X, Zhang B, Zhao Y, Xiao Y, Yang X, Yang H, Guddat LW, Li J, Rao Z. LW, Li J*, Rao Z*. Structural insights into substrate recognition by the type VII secretion system. Protein & Cell. 2019 Nov 23. ISSN:1674-8018

  3. Zhang S, Xiong H, Lu F, Ma F, Gu Y, Ma P*, Xu H*, Yang G*. Synthesis of N-Acyl Sulfamates from Fluorosulfonates and Potassium Trimethylsilyloxyl Imidates. J Org Chem. 2019 Nov 12. ISSN:0022-3263

  4. Wang N#, Zhao D#, Wang J#, Zhang Y#, Wang M, Gao Y, Li F, Wang J, Bu Z*, Rao Z*, Wang X*. Architecture of African swine fever virus and implications for viral assembly. Science. 2019 Nov 1. ISSN:0033-3131

  5. Zhao, Quanju1#; Ren, Chaowei#; Liu, Linyi#; Chen, Jinju; Shao, Yubao; Sun, Ning; Sun, Renhong; Kong, Ying; Ding, Xinyu; Zhang, Xianfang; Xu, Youwei; Yang, Bei; Yin, Qianqian*; Yang, Xiaobao*; Jiang, Biao*. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. Journal of Medicinal Chemistry. 2019 Oct 2. ISSN:0022-2623

  6.  Xu H#.Ma F#.Wang N.Hou W.Xiong H.Lu F, Li J.Wang S.Ma P.Yang G*.Lerner RA*. DNA-Encoded Libraries: Aryl Fluorosulfonates as Versatile Electrophiles Enabling Facile On-DNA Suzuki, Sonogashira, and Buchwald Reactions. Advanced Science. 2019 Sep 30. ISSN:2198-3844

  7. Wang M#, Guo X#, Yang X, Zhang B, Ren J, Liu A, Ran Y, Yan B, Chen F, Guddat LW, Hu J*, Li J* and Rao Z. Mycobacterial dynamin-like protein IniA mediates membrane fission. Nat Commun. 2019 Aug 29. ISSN:2041-1723

  8. Wang, Yannan#;  Zhang, Fan;  Nie, Yan*;  Shang, Guijun*;  Zhang, Heqiao*. Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis. Biochemical and Biophysical Research Communications. 2019 Aug 20. ISSN:0006-291X

  9. Yang Z, Wan Y, Tao P, Qiang M, Dong X, Lin CW, Yang G, Zheng T*, Lerner RA*. A cell-cell interaction format for selection of high-affinity antibodies to membrane proteins. Proc Natl Acad Sci U S A. 2019 Jul 23. ISSN:0027-8424

  10. Wang Chen#, Yang Zhenzhen, Guo Fanghao, Shi Shuo, Han Xiaoshuai, Zeng An, Lin Haifan*, Jing Qing*. Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea. J Biol Chem. 2019 Jun 21. ISSN:0021-9258

  11. Rong Huang,# Wei Zhu,# Yue Wu,# Jiakang Chen, Jianghui Yu, Biao Jiang,* Hongli Chen * and Wenzhang Chen*. A novel mass spectrometry-cleavable, phosphatebased enrichable and multi-targeting protein cross-linker. Chemical Science. 2019 May 23. ISSN:1452-3981

  12.  Ma P#, Xu H#, Li J#, Lu F, Ma F, Wang S, Xiong H, Wang W, Buratto D, Zonta F, Wang N, Liu K, Hua T, Zhi-jie Liu, Yang G*, Lerner RA*. Functionality independent DNA encoding of complex natural products. Angew Chem Int Ed Engl. 2019 May 22. ISSN:1433-7851

  13. Rong Huang, Zhihong Li, Jianghui Yu, Hongli Chen,* and Biao Jiang*. H2O‑Regulated Chemoselectivity in Oxa-Versus Aza-Michael Reactions. Organic Letters. 2019 May 16. ISSN:1523-7060

  14. W. Hou, B. Liu*, H. Xu*. Triptolide: medicinal chemistry, chemical biology and clinical progress. Eur. J. Med. Chem. 2019 May 13. ISSN:0223-5234 

  15. Qiu, Xing#; Sun, Ning#; Kong, Ying; Li, Yan; Yang, Xiaobao*; Jiang, Biao* . Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Organic Letters. 2019 May 8. ISSN:1523-7060

  16. Li B#, Zhou X-H# Yang P-Y, Zhu L, Zhong Y, Cai Z, Jiang B, Cai X, Liu J*, Jiang X*. Photoactivatable Fluorogenic Labeling via Turn-On Click-Like Nitroso-Diene Bioorthogonal Reaction. Advanced Science. 2019 May 2. ISSN:2198-3844

  17. Xia S#, Yan L#, Xu W, Agrawal AS, Algaissi A, Tseng CK, Wang Q, Du L, Tan W, Wilson IA*, Jiang S*, Yang B*, Lu L*. A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Science Advances. 2019 Apr 10. ISSN:2375-2548  

  18. Bian Hu#, Yan Zou, Linlin Zhang, Jiaxing Tang, Gabriele Niedermann, Elke Firat, Xingxu Huang*, and Xuekai Zhu*. Nucleofection with Plasmid DNA for CRISPR/Cas9-Mediated Inactivation of Programmed Cell Death Protein 1 in CD133-Specific CAR T Cells. Human Gene Therapy. 2019 Apr 10. ISSN:1557-7422  

  19. Shi X#, Xiao Z#, Zonta F, Wang W, Wan Y, Li Y, Wang N, Kuang Y, Du M, Dong J, Wang J, Yang G*. Somatic MIWI2 Hinders Direct Lineage Reprogramming From Fibroblast to Hepatocyte. Stem Cells. 2019 Feb 28. ISSN:1066-5099  

  20. Gagliano O#, Luni C#, Qin W, Bertin E, Torchio E, Galvanin S, Urciuolo A, Elvassore N*.. Microfluidic reprogramming to pluripotency of human somatic cells. Nat Prot. 2019. ISSN:1745-2473 

  21. Zhang B#, Li J#*, Yang X, Wu L, Zhang J, Yang Y, Zhao Y, Zhang L, Yang X, Yang X, Cheng X, Liu Z, Jiang B, Jiang H, Guddat LW, Yang H*, Rao Z*. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24. ISSN: 0092-8674