2020

1. gem-Difluoromethylene Alkyne-Enabled Diverse C-H Functionalization and Application to the on-DNA Synthesis of Difluorinated Isocoumarins. Gao, Hui(3,4,5);Lin, Shuang(3,4,5);Zhang, Shuning(1,2);Chen, Weijie(3,4,5);Liu, Xiamen(3,4,5);Yang, Guang(1);Richard A. Lerner(6);Xu, Hongtao(1);Zhou, Zhi(3,4,5);Yi, Wei(3,4,5). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020. DOI:. 10.1002/anie.202013052

2. Coarse-Grained Parameters for Divalent Cations within the SIRAH Force Field. Klein, Florencia(1);Caceres, Daniela(2,3);Carrasco, Monica A.(2);Carlos Tapia, Juan(2);Caballero, Julio(3);Alzate-Morales, Jans(3);Pantano, Sergio(1,4). JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2020. DOI:. 10.1021/acs.jcim.0c00160

3. Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study. Zang, Xuefeng(1);Wang, Qian(2);Zhou, Hua(3);Liu, Sanhong(4,5);Xue, Xinying(6,7). INTENSIVE CARE MEDICINE. 2020. DOI:. 10.1007/s00134-020-06182-4

4. Tripterygium glycoside fraction n2 ameliorates adriamycin-induced nephrotic syndrome in rats by suppressing apoptosis. Wang, Xiao-wan(1);Tian, Rui-min(2);Yang, Yi-qi(1);Wang, Kai(1);Li, En-nian(1);Han, Xiao-dong(1);Bao, Kun(2);Mao, Wei(1);Xu, Hong-tao(3);Liu, Bo(1,4);Xu, Peng(2). JOURNAL OF ETHNOPHARMACOLOGY. 2020. DOI:. 10.1016/j.jep.2020.112789

5. Selection of Small Molecules that Bind to and Activate the Insulin Receptor from a DNA-Encoded Library of Natural Products. Xie, Jia(1);Wang, Shuyue(2,3,4,5);Ma, Peixiang(2);Ma, Fei(1,2,5);Li, Jie(2,3,4);Wang, Wei(2);Lu, Fengping(2);Xiong, Huan(2);Gu, Yuang(2,3,4,5);Zhang, Shuning(2,3,4,5);Xu, Hongtao(2);Yang, Guang(2);Lerner, Richard A.(1). ISCIENCE. 2020. DOI:. 10.1016/j.isci.2020.101197

6. Intravital three-dimensional bioprinting. Urciuolo, Anna(1,2,3);Poli, Ilaria(4);Brandolino, Luca(1,2);Raffa, Paolo(2,3);Scattolini, Valentina(2,3);Laterza, Cecilia(1,2);Giobbe, Giovanni G.(5);Zambaiti, Elisa(3);Selmin, Giulia(5);Magnussen, Michael(5);Brigo, Laura(2);De Coppi, Paolo(5,6);Salmaso, Stefano(7);Giomo, Monica(1);Elvassore, Nicola(1,2,5,8). NATURE BIOMEDICAL ENGINEERING. 2020. DOI:. 10.1038/s41551-020-0568-z

7. Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma. Xue, Xin-ying(1,2,3);Liu, Yu-xia(4);Wang, Chen(5);Gu, Xin-jin(6);Xue, Zhi-qiang(7);Zang, Xue-lei(8);Ma, Xi-dong(3);Deng, Hui(1);Liu, Rong(6);Pan, Lei(1);Liu, San-hong(5). SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2020. DOI:. 10.1038/s41392-020-0162-6

8. Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity. Zhang, Xiaotian(1,4);Jeong, Mira(1,2);Huang, Xingfan(3,7,8,17);Wang, Xue Qing(4);Wang, Xinyu(5);Zhou, Wanding(4);Shamim, Muhammad S.(3,6,7,8);Gore, Haley(4);Himadewi, Pamela(4);Liu, Yushuai(4);Bochkov, Ivan D.(3,9);Reyes, Jaime(1,2,9);Doty, Madison(10);Huang, Yung-Hsin(1,2,11);Jung, Haiyoung(1,2,12);Heikamp, Emily(1,2,13);Aiden, Aviva Presser(3,11,13);Li, Wei(14,15);Su, Jianzhong(5);Aiden, Erez Lieberman(3,7,8,9,16);Goodell, Margaret A.(1,2,9,13,15). MOLECULAR CELL. 2020. DOI:. 10.1016/j.molcel.2020.04.018

9. Engineering a 3D in vitro model of human skeletal muscle at the single fiber scale. Urciuolo, Anna(1,2,3);Serena, Elena(1,2);Ghua, Rusha(4);Zatti, Susi(1,2);Giomo, Monica(1,2);Mattei, Nicolo(1,2);Vetralla, Massimo(1,2);Selmin, Giulia(1);Luni, Camilla(5);Vitulo, Nicola(6);Valle, Giorgio(4);Vitiello, Libero(4,7);Elvassore, Nicola(1,2,5,8). PLOS ONE. 2020. DOI:. 10.1371/journal.pone.0232081

10. Exosomal piRNA profiling revealed unique circulating piRNA signatures of cholangiocarcinoma and gallbladder carcinoma. Gu, Xinjin(1);Wan, Chen(2);Deng, Hui(3);Qing, Chong(3);Liu, Rong(1);Liu, Sanhong(2);Xue, Xinying(3). ACTA BIOCHIMICA ET BIOPHYSICA SINICA. 2020. DOI:. 10.1093/abbs/gmaa028

11. Establishment of SIAISi002-A, an induced pluripotent stem cell (iPSC) line from 39-year old healthy female donor with a family history of Alzheimer's disease (AD) and two copies of APOE4 gene. Yan, Yi(1,2);Qiu, Yinghui(1,2);Zhao, Aonan(1,2);Zhao, Jian(3,4);Wang, Ying(3);Deng, Yulei(1,2). STEM CELL RESEARCH. 2020. DOI:. 10.1016/j.scr.2020.101792

12. Bcl-3 promotes Wnt signaling by maintaining the acetylation of beta-catenin at lysine 49 in colorectal cancer. Chen, Xi(1);Wang, Chen(1,2);Jiang, Yuhang(1,3);Wang, Qi(1);Tao, Yu(1,3);Zhang, Haohao(1,3);Zhao, Yongxu(1);Hu, Yiming(1,3);Li, Cuifeng(1,3);Ye, Deji(1);Liu, Dandan(1);Jiang, Wenxia(1);Chin, Eugene Y.(1);Chen, Sheng(4);Liu, Yongzhong(5);Wang, Mingliang(6);Liu, Sanhong(1,2);Zhang, Xiaoren(1,3). SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2020. DOI:. 10.1038/s41392-020-0138-6

13. Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology. Hou, Wei(1,2);Liu, Bo(3,4);Xu, Hongtao(5). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2020. DOI:. 10.1016/j.ejmech.2020.112081

14. Exosomal miRNA profiling before and after surgery revealed potential diagnostic and prognostic markers for lung adenocarcinoma. Xue, Xinying(1,2);Wang, Chen(3);Xue, Zhiqiang(4);Wen, Jiaxin(4);Han, Jun(5);Ma, Xidong(6);Zang, Xuelei(7);Deng, Hui(2);Guo, Rui(2);Asuquo, Idorenyin Polycarp(8);Qin, Chong(2);Wang, Haijiao(2);Gao, Quansheng(9);Liu, Sanhong(3);Wang, Jianxin(1). ACTA BIOCHIMICA ET BIOPHYSICA SINICA. 2020. DOI:. 10.1093/abbs/gmz164

15. Establishment of SIAISi001-A, an induced pluripotent stem cell (iPSC) line from 66-year old mild cognitive impairment (MCI) with two copies of APOE4 gene. Yan, Yi(1,2);Qiu, Yinghui(1,2);Zhao, Aonan(1,2);Zhao, Jian(3);Wang, Ying(3);Deng, Yulei(1,2). STEM CELL RESEARCH. 2020. DOI:. 10.1016/j.scr.2020.101702

16. ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin(STAG1) from WAPL. Wutz, Gordana(1);Ladurner, Rene(1,15);St Hilaire, Brian Glenn(2,3,4);Stocsits, Roman R.(1);Nagasaka, Kota(1);Pignard, Benoit(1);Sanborn, Adrian(2,5);Tang, Wen(1);Varnai, Csilla(6,7);Ivanov, Miroslav P.(1,16);Schoenfelder, Stefan(6,17);van der Lelij, Petra(1);Huang, Xingfan(2,8,9,10);Duernberger, Gerhard(11,18);Roitinger, Elisabeth(11);Mechtler, Karl(1,11);Davidson, Iain Finley(1);Fraser, Peter(6,12);Lieberman-Aiden, Erez(2,3,4,8,13,14);Peters, Jan-Michael(1). ELIFE. 2020. DOI:. 10.7554/eLife.52091

17. Post-Translational Modifications at the Coarse-Grained Level with the SIRAH Force Field. Garay, Pablo G.(1);Barrera, Exequiel E.(1);Pantano, Sergio(1,2). JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2020. DOI:. 10.1021/acs.jcim.9b00900

18. An ultra-stable cytoplasmic antibody engineered for in vivo applications. Kabayama, Hiroyuki(1,2);Takeuchi, Makoto(1);Tokushige, Naoko(1);Muramatsu, Shin-ichi(3,4);Kabayama, Miyuki(5);Fukuda, Mitsunori(6);Yamada, Yoshiyuki(1);Mikoshiba, Katsuhiko(1,7,8). NATURE COMMUNICATIONS. 2020. DOI:. 10.1038/s41467-019-13654-9

19. Architecture of a SARS-CoV-2 mini replication and transcription complex. Yan, Liming(1);Zhang, Ying(2);Ge, Ji(2);Zheng, Litao(2);Gao, Yan(1,3,4);Wang, Tao(1);Jia, Zhihui(5);Wang, Haofeng(3,4);Huang, Yucen(1);Li, Mingyu(1);Wang, Quan(3,4);Rao, Zihe(1,2,3,4);Lou, Zhiyong(1). NATURE COMMUNICATIONS. 2020. DOI:. 10.1038/s41467-020-19770-1

20. Automated design and optimization of multitarget schizophrenia drug candidates by deep learning. Tan, Xiaoqin(1,2);Jiang, Xiangrui(3);He, Yang(3);Zhong, Feisheng(1,2);Li, Xutong(1,2);Xiong, Zhaoping(1,4,5);Li, Zhaojun(1,6);Liu, Xiaohong(1,4,5);Cui, Chen(1,2);Zhao, Qingjie(3);Xie, Yuanchao(3);Yang, Feipu(3);Wu, Chunhui(3);Shen, Jingshan(3);Zheng, Mingyue(1,2);Wang, Zhen(3);Jiang, Hualiang(1,2,4,5). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2020. DOI:. 10.1016/j.ejmech.2020.112572

21. Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase. Xu, Yechun(1,2);Jiang, Hualiang(1,2,3,4). PROTEIN & CELL. 2020. DOI:. 10.1007/s13238-020-00769-9

22. Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs. Yu, Bo(1,2);Li, Chenze(1,2);Chen, Peng(1,2);Li, Jia(3);Jiang, Hualiang(3,4,5);Wang, Dao-Wen(1,2). SCIENCE CHINA-LIFE SCIENCES. 2020. DOI:. 10.1007/s11427-020-1782-1

23. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Su, Hai-xia(1,2);Yao, Sheng(2,3);Zhao, Wen-feng(1,4,5);Li, Min-jun(6);Liu, Jia(2,3);Shang, Wei-juan(7);Xie, Hang(1);Ke, Chang-qiang(3);Hu, Hang-chen(1,2);Gao, Mei-na(1,2);Yu, Kun-qian(1,2);Liu, Hong(2,3);Shen, Jing-shan(1,2);Tang, Wei(1,2);Zhang, Lei-ke(7);Xiao, Geng-fu(7);Ni, Li(8,9);Wang, Dao-wen(8,9);Zuo, Jian-ping(2,3);Jiang, Hua-liang(1,2,10,11);Bai, Fang(10,11);Wu, Yan(7);Ye, Yang(2,3,11);Xu, Ye-chun(1,2). ACTA PHARMACOLOGICA SINICA. 2020. DOI:. 10.1038/s41401-020-0483-6

24. Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model. Zhao, Jihui(1,5);Cui, Rongrong(1,2);Wang, Lihao(1,6);Chen, Yingjia(1);Fu, Zunyun(1,2);Ding, Xiaoyu(1);Cui, Chen(1);Yang, Tianbiao(1);Li, Xutong(1);Xu, Yuan(1,7);Chen, Kaixian(1,2,3,4);Luo, Xiaomin(1);Jiang, Hualiang(1,2,3,4);Zheng, Mingyue(1,5). JOURNAL OF MEDICINAL CHEMISTRY. 2020. DOI:. 10.1021/acs.jmedchem.9b01895

25. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Dai, Wenhao(1,2);Zhang, Bing(3,4);Jiang, Xia-Ming(5);Su, Haixia(1,6);Li, Jian(1,6);Zhao, Yao(3,4);Xie, Xiong(1,6);Jin, Zhenming(3,4);Peng, Jingjing(1,6);Liu, Fengjiang(3,4);Li, Chunpu(1,6);Li, You(8);Bai, Fang(3,4);Wang, Haofeng(3,4);Cheng, Xi(1);Cen, Xiaobo(8);Hu, Shulei(1);Yang, Xiuna(3,4);Wang, Jiang(1,6);Liu, Xiang(9);Xiao, Gengfu(5);Jiang, Hualiang(1,3,4,6);Rao, Zihe(3,4);Zhang, Lei-Ke(5);Xu, Yechun(1,6);Yang, Haitao(3,4);Liu, Hong(1,6,7). SCIENCE. 2020. DOI:. 10.1126/science.abb4489

26. Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2). Zhang, Lu(1);Zhao, Yao(2,3,4);Gao, Ruogu(4,5);Li, Jun(3,4);Yang, Xiuna(3,4);Gao, Yan(9);Zhao, Wei(1,2);Gurcha, Sudagar S.;Veerapen, Natacha(10);Batt, Sarah M.;Besra, Kajelle Kaur;Xu, Wenqing(3,4);Bi, Lijun(7,8);Zhang, Xian'en(8);Guddat, Luke W.(11);Yang, Haitao(3,4);Wang, Quan(3,4,7,8);Besra, Gurdyal S.(10);Rao, Zihe(1,2,3,4,7,8,9). PROTEIN & CELL. 2020. DOI:. 10.1007/s13238-020-00726-6

27. Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis. Uyhazi, Katherine E.(1);Yang, Yiying(1,2,3);Liu, Na(1);Qi, Hongying(1);Huang, Xiao A.(1);Mak, Winifred(1,4);Weatherbee, Scott D.(5);de Prisco, Nicola(6,7,8);Gennarino, Vincenzo A.(6,7,8,9);Song, Xiaoling(2);Lin, Haifan(1,2,3,4,5). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. DOI:. 10.1073/pnas.1916471117

28. Host-mediated ubiquitination of a mycobacterial protein suppresses immunity. Wang, Lin(1);Wu, Juehui(1,2);Li, Jun(3,4);Yang, Hua(1);Tang, Tianqi(2);Liang, Haijiao(1,2);Zuo, Mianyong(2);Wang, Jie(1);Liu, Haipeng(1,5);Liu, Feng(1);Chen, Jianxia(1,5);Liu, Zhonghua(1);Wang, Yang(2);Peng, Cheng(2);Wu, Xiangyang(2);Zheng, Ruijuan(1);Huang, Xiaochen(1);Ran, Yajun(3,4);Rao, Zihe(3,4,6,7,8,9);Ge, Baoxue(1,2,5). NATURE. 2020. DOI:. 10.1038/s41586-019-1915-7

29. Meeting organometallic chemistry with drug discovery: C-H activation enabled discovery of a new ring system of 12H-Indazolo[2,1-a]cinnolin-12-ones with anti-proliferation activity. Zhang, Xiang(1);Bai, Ruisong(2,3);Xiong, Huan(4);Xu, Hongtao(4);Hou, Wei(2,3). BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2020. DOI:. 10.1016/j.bmcl.2019.126916

30. MeCas12a, a Highly Sensitive and Specific System for COVID-19 Detection. Ma, Peixiang(1);Meng, Qingzhou(2);Sun, Baoqing(3);Zhao, Bing(4);Dang, Lu(2);Zhong, Mingtian(5);Liu, Siyuan(6);Xu, Hongtao(1);Mei, Hong(1);Liu, Jia(1);Chi, Tian(6);Yang, Guang(1);Liu, Ming(3);Huang, Xingxu(6);Wang, Xinjie(1). ADVANCED SCIENCE. 2020. DOI:. 10.1002/advs.202001300

31. PIWIL1 promotes gastric cancer via a piRNA-independent mechanism. Shi, Shuo(1);Yang, Zhen-Zhen(1);Liu, Sanhong(1);Yang, Fan(1);Lin, Haifan(2,3). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. DOI:. 10.1073/pnas.2008724117

32. Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations. He, Di(1,2);Wang, Di(2);Lu, Ping(3);Yang, Nan(4);Xue, Zhigang(3);Zhu, Xianmin(1,2);Zhang, Peng(2);Fan, Guoping(1,5). ONCOGENE. 2020. DOI:. 10.1038/s41388-020-01528-0

33. Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton. Martewicz, Sebastian(1);Luni, Camilla(1);Zhu, Xi(1,2,3);Cui, Meihua(1);Hu, Manli(1);Qu, Siqi(1,2);Buratto, Damiano(1);Yang, Guang(1);Grespan, Eleonora(4);Elvassore, Nicola(1,5,6,7). CELLS. 2020. DOI:. 10.3390/cells9112509

34. Divinylsulfonamides enable the construction of homogeneous antibody–drug conjugates. Rong Huang(1,2);Yao Sheng(1);Ding Wei(1,2,3);Wenwen Lu(1,2);Hongli Chen(1);Biao Jiang(1). BIOORGANIC & MEDICINAL CHEMISTRY. 2020. DOI:. 10.1016/j.bmc.2020.115793

35. Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. Liu, Fengjiang(1,2,3);Liang, Jingxi(4);Zhang, Bing(1);Gao, Yan(1,5);Yang, Xiuna(1);Hu, Tianyu(1);Yang, Haitao(1);Xu, Wenqing(1);Guddat, Luke W.(6);Rao, Zihe(1,4,5,7). SCIENCE ADVANCES. 2020. DOI:. 10.1126/sciadv.abb9833

36. Decision tree searching strategy to boost the identification of cross-linked peptides.. Huang, Rong(1,2);Gao, Xiuxia(1);Xu, Zili(1);Zhu, Wei(1);Wei, Ding(1,2);Jiang, Biao(1);Chen, Hongli(1);Chen, Wenzhang(1). ANALYTICAL CHEMISTRY. 2020. DOI:. 10.1021/acs.analchem.0c00452

37. Inhibitory antibodies identify unique sites of therapeutic vulnerability in rhinovirus and other enteroviruses. Meng, Bing(1);Lan, Keke(1,2);Xie, Jia(3);Lerner, Richard A.(3);Wilson, Ian A.(1,4,5);Yang, Bei(1). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. DOI:. 10.1073/pnas.1918844117

38. Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury. Dong, Yixiao(1,2,3);Cui, Meihua(1);Qu, Ju(1);Wang, Xuechun(1);Kwon, Sun Hyung(2);Barrera, Janos(2);Elvassore, Nicola(1);Gurtner, Geoffrey C.(2). ACTA BIOMATERIALIA. 2020. DOI:. 10.1016/j.actbio.2020.03.040

39. Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance. Sun, Ning(1);Ren, Chaowei(1);Kong, Ying(5);Zhong, Hui(1,3);Chen, Jinju(5);Li, Yan(5);Zhang, Jianshui(5);Zhou, Yuedong(5);Qiu, Xing(2);Lin, Haifan(1,4);Song, Xiaoling(1);Yang, Xiaobao(1);Jiang, Biao(1,2). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2020. DOI:. 10.1016/j.ejmech.2020.112190

40. Iridium-catalyzed C-H amidation of s-tetrazines. Xiong, Huan(1);Gu, Yuang(1,2,3,4);Zhang, Shuning(1,2,3,4);Lu, Fengping(1);Ji, Qun(1);Liu, Lili(1);Ma, Peixiang(1);Yang, Guang(1);Hou, Wei(5,6);Xu, Hongtao(1). CHEMICAL COMMUNICATIONS. 2020. DOI:. 10.1039/d0cc01647k

41. A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries. Xu, Hongtao(1);Gu, Yuang(1,4,5,6);Zhang, Shuning(1,4,5,6);Xiong, Huan(1);Ma, Fei(1);Lu, Fengping(1);Ji, Qun(1);Liu, Lili(1);Ma, Peixiang(1);Hou, Wei(2,3);Yang, Guang(1);Lerner, Richard A.(7). ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2020. DOI:. 10.1002/anie.202003595

42. Beyond Family: Modeling Non-hereditary Heart Diseases With Human Pluripotent Stem Cell-Derived Cardiomyocytes. Martewicz, Sebastian(1);Magnussen, Michael(2);Elvassore, Nicola(1,2,3,4). FRONTIERS IN PHYSIOLOGY. 2020. DOI:. 10.3389/fphys.2020.00384

43. Bis(vinylsulfonyl)piperazines as efficient linkers for highly homogeneous antibody-drug conjugates. Huang, Rong(1,2);Sheng, Yao(1);Wei, Ding(1,2);Yu, Jianghui(1,2);Chen, Hongli(1);Jiang, Biao(1). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2020. DOI:. 10.1016/j.ejmech.2020.112080

44. A Synthetic Human Antibody Antagonizes IL-18R beta Signaling Through an Allosteric Mechanism. Liu, Shusu(1);Miersch, Shane(2);Li, Ping(1,3);Bai, Bingxin(1);Liu, Chunchun(1);Qin, Wenming(4);Su, Jie(1);Huang, Haiming(2,5);Pan, James(2);Sidhu, Sachdev S.(1,2);Wu, Donghui(1). JOURNAL OF MOLECULAR BIOLOGY. 2020. DOI:. 10.1016/j.jmb.2020.01.012

45. Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cell Culture Prevents UVB-Induced Skin Aging in Human Keratinocytes and Dermal Fibroblasts. Li, Lu(1,2);Ngo, Hien T. T.(2);Hwang, Eunson(2);Wei, Xuan(1);Liu, Ying(2);Liu, Jia(1);Yi, Tae-Hoo(2). INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. DOI:. 10.3390/ijms21010049

46. Rapid and sensitive detection of COVID-19 using CRISPR/Cas12a-based detection with naked eye readout, CRISPR/Cas12a-NER. Wang, Xinjie(1);Zhong, Mingtian(2);Liu, Yong(3,4);Ma, Peixiang(1);Dang, Lu(5);Meng, Qingzhou(5);Wan, Wenwei(6);Ma, Xiaodong(2);Liu, Jia(1);Yang, Guang(1);Yang, Zifeng(3);Huang, Xingxu(6);Liu, Ming(3). SCIENCE BULLETIN. 2020. DOI:. 10.1016/j.scib.2020.04.041

47. Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Chen, Xiaobo(1,2,3);Chen, Jiayue(1);Yan, Bing(1);Zhang, Wei(1);Guddat, Luke W.(4);Liu, Xiang(1);Rao, Zihe(1,2,3,5,6). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020. DOI:. 10.1073/pnas.2002835117

48. A DNA-encoded library for the identification of natural product binders that modulate poly (ADP-ribose) polymerase 1, a validated anti-cancer target. Li, Jie(1,2,3,4);Li, Yu(1,2,3,4);Lu, Fengping(1);Liu, Lili(1);Ji, Qun(1);Song, Ke(1);Yin, Qianqian(1);Lerner, Richard A.(5);Yang, Guang(1);Xu, Hongtao(1);Ma, Peixiang(1). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020. DOI:. 10.1016/j.bbrc.2020.04.022

49. Generation of an induced pluripotent stem cell line (SIAISi003-A) from a 79-year-old patient with Alzheimer's disease having APOE3/4 genetic background. Dai, Qiuting(1,2);Zhang, Wenxin(1,2);Guo, Jinghui(1,2);Di, Weihao(1,2);Zhao, Jian(1,2);Zhang, Bei(3);Wang, Ying(1). STEM CELL RESEARCH. 2020. DOI:. 10.1016/j.scr.2020.101949

50. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo. Tao, Pingdong(1,2,3,4);Kuang, Yuanyuan(1,2,3,4);Li, Yu(1,2,3,4);Li, Wenping(1,2,3,4);Gao, Zibei(2);Liu, Lili(1);Qiang, Min(1);Zha, Zhao(1);Fan, Kun(1,2,3,4);Ma, Peixiang(1);Friedman, Jeffrey M.(5);Yang, Guang(1);Lerner, Richard A.(6). ADVANCED SCIENCE. 2020. DOI:. 10.1002/advs.202000818

51. A potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice. Kuang, Yuanyua(1,2,3,4);Zorzi, Veronica(5,6);Buratto, Damiano(1);Ziraldo, Gaia(5,6);Mazzarda, Flavia(5,7);Peres, Chiara(5,8);Nardin, Chiara(5,8);Salvatore, Anna Maria(5);Chiani, Francesco(5);Scavizzi, Ferdinando(5);Raspa, Marcello(5);Qiang, Min(1);Chu, Youjun(1);Shi, Xiaojie(1);Li, Yu(1,2,3,4);Liu, Lili(1);Shi, Yaru(1);Zonta, Francesco(1);Yang, Guang(1);Lerner, Richard A.(1,9);Mammano, Fabio(1,5,8). EBIOMEDICINE. 2020. DOI:. 10.1016/j.ebiom.2020.102825

52. Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides. Cui, Yan-ru(1,2,3,4);Wang, Shao-jie(1);Chen, Jun(5);Li, Jie(1,2,3,4);Chen, Wenzhang(1);Wang, Shuyue(1,2,3,4);Meng, Bing(1);Zhu, Wei(1);Zhang, Zhuhong(6);Yang, Bei(1);Jiang, Biao(1);Yang, Guang(1);Ma, Peixiang(1);Liu, Jia(1). GENOME BIOLOGY. 2020. DOI:. 10.1186/s13059-020-01956-x

53. Parabrachial neuron types categorically encode thermoregulation variables during heat defense. Wen Z. Yang(1,2,3);Xiaosa Du(1,2,4,5);Wen Zhang(4);Cuicui Gao(1,2,4,5);Hengchang Xie(1,2,4,5);Yan Xiao(6,7);Xiaoning Jia(1,2);Jiashu Liu(1,2);Jianhui Xu(8);Xin Fu(1,2,4,5);Hongqing Tu(1,2,4,5);Xiaoyu Fu(1,2,4,5);Xinyan Ni(1,2);Miao He(9);Jiajun Yang(6,7);Hong Wang(10);Haitao Yang(1,2);Xiao-hong Xu(4);Wei L. Shen(1,2). SCIENCE ADVANCES. 2020. DOI:. 10.1126/sciadv.abb9414

54. Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO. Yang, Xiaolin(1,2,3,8);Hu, Tianyu(1,2);Yang, Xiuna(1,2);Xu, Wenqing(1,2);Yang, Haitao(1,2);Guddat, Luke W.(7);Zhang, Bing(1,2);Rao, Zihe(1,2,4,5,6). JOURNAL OF MOLECULAR BIOLOGY. 2020. DOI:. 10.1016/j.jmb.2020.05.019

55. Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Wang, Quan(1,2);Wu, Jiqin(3);Wang, Haofeng(1,2,4);Gao, Yan(5);Liu, Qiaojie(3);Mu, An(6,7);Ji, Wenxin(6,7);Yan, Liming(5);Zhu, Yan(1,2);Zhu, Chen(1,2);Fang, Xiang(3,6);Yang, Xiaobao(1,2);Huang, Yucen(5);Gao, Hailong(6,7);Liu, Fengjiang(1,2);Ge, Ji(5);Sun, Qianqian(1,2);Yang, Xiuna(1,2);Xu, Wenqing(1,2);Liu, Zhijie(1,2);Yang, Haitao(1,2);Lou, Zhiyong(5);Jiang, Biao(1,2);Guddat, Luke W.(8);Gong, Peng(3);Rao, Zihe(1,2,5,7). CELL. 2020. DOI:. 10.1016/j.cell.2020.05.034

56. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Gao, Yan(1,2,3,4);Yan, Liming(1,2);Huang, Yucen(1,2);Liu, Fengjiang(3,4);Zhao, Yao(3,4);Cao, Lin(5,6);Wang, Tao(1,2);Sun, Qianqian(3,4);Ming, Zhenhua(7);Zhang, Lianqi(1,2);Ge, Ji(1,2);Zheng, Litao(1,2);Zhang, Ying(1,2);Wang, Haofeng(3,4,8);Zhu, Yan(3,4);Zhu, Chen(3,4);Hu, Tianyu(3,4);Hua, Tian(3,4);Zhang, Bing(3,4);Yang, Xiuna(3,4);Li, Jun(3,4);Yang, Haitao(3,4);Liu, Zhijie(3,4);Xu, Wenqing(3,4);Guddat, Luke W.(9);Wang, Quan(3,4);Lou, Zhiyong(1,2);Rao, Zihe(1,2,3,4,5,6,10). SCIENCE. 2020. DOI:. 10.1126/science.abb7498

57. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Jin, Zhenming(1,2,3,4);Zhao, Yao(1,2);Sun, Yuan(5);Zhang, Bing(1,2);Wang, Haofeng(1,2,6);Wu, Yan(5);Zhu, Yan(1,2);Zhu, Chen(1,2);Hu, Tianyu(1,2);Du, Xiaoyu(1,2,3,4);Duan, Yinkai(1,2);Yu, Jing(1,2);Yang, Xiaobao(1,2);Yang, Xiuna(1,2);Yang, Kailin(7);Liu, Xiang(8);Guddat, Luke W.(9);Xiao, Gengfu(5);Zhang, Leike(5);Yang, Haitao(1,2);Rao, Zihe(1,2,3,4,8). NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2020. DOI:. 10.1038/s41594-020-0440-6

58. Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors. Jin, Zhenming(1,2,3,4);Du, Xiaoyu(3,4);Xu, Yechun(5);Deng, Yongqiang(6);Liu, Meiqin(7);Zhao, Yao(1,2);Zhang, Bing(1,2);Li, Xiaofeng(6);Zhang, Leike(7);Peng, Chao(8);Duan, Yinkai(1,2);Yu, Jing(1,2);Wang, Lin(1,2);Yang, Kailin(9);Liu, Fengjiang(1,2);Jiang, Rendi(7);Yang, Xinglou(7);You, Tian(1,2);Liu, Xiaoce(1,2);Yang, Xiuna(1,2);Bai, Fang(1,2);Liu, Hong(5);Liu, Xiang(10);Guddat, Luke W.(11);Xu, Wenqing(1,2,8);Xiao, Gengfu(7);Qin, Chengfeng(6);Shi, Zhengli(7);Jiang, Hualiang(1,2,5);Rao, Zihe(1,2,3,4,10);Yang, Haitao(1,2). NATURE. 2020. DOI:. 10.1038/s41586-020-2223-y

59. Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. Zhang, Lu(1,2,3,4);Zhao, Yao(1,2,3,5,6);Gao, Yan(7);Wu, Lijie(1,2,3);Gao, Ruogu(6,8,9);Zhang, Qi(1,2,3);Wang, Yinan(1,2,3,6);Wu, Chengyao(1,2,3);Wu, Fangyu(4);Gurcha, Sudagar S.(10);Veerapen, Natacha(10);Batt, Sarah M.(10);Zhao, Wei(4);Qin, Ling(1,2,3,12);Yang, Xiuna(1,2,3);Wang, Manfu(1,2,3);Zhu, Yan(1,2,3);Zhang, Bing(1,2,3);Bi, Lijun(8,9);Zhang, Xian'en(8,9);Yang, Haitao(1,2,3);Guddat, Luke W.(11);Xu, Wenqing(1,2,3);Wang, Quan(1,2,3,8,9);Li, Jun(1,2,3);Besra, Gurdyal S.(10);Rao, Zihe(1,2,3,4,7,8,9). SCIENCE. 2020. DOI:. 10.1126/science.aba9102

60. IP3 Receptor Plasticity Underlying Diverse Functions. Hamada, Kozo(1);Mikoshiba, Katsuhiko(1). ANNUAL REVIEW OF PHYSIOLOGY. 2020. DOI:. 10.1146/annurev-physiol-021119-034433

61. Intellectual disability-associated geneftsj1is responsible for 2 '-O-methylation of specific tRNAs. Li, Jing(1,2);Wang, Yan-Nan(3);Xu, Bei-Si(4);Liu, Ya-Ping(5);Zhou, Mi(1);Long, Tao(1);Li, Hao(1);Dong, Han(1);Nie, Yan(3);Chen, Peng R.(5);Wang, En-Duo(1,2);Liu, Ru-Juan(2). EMBO REPORTS. 2020. DOI:. 10.15252/embr.202050095

62. Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response. Wang, Xiao(1,2,3);Ding, Chengfeng(1,2,3);Yu, Wenxia(1,2,3);Wang, Ying(4);He, Siting(3,5);Yang, Bei(6);Xiong, Yi-Chun(4);Wei, Jia(4);Li, Jifang(1,2,3);Liang, Jiayi(1,2,3);Lu, Zongyang(1,2,3);Zhu, Wei(1);Wu, Jing(1);Zhou, Zhi(1);Huang, Xingxu(1,2);Liu, Zhen(5);Yang, Li(4);Chen, Jia(1,2). CELL REPORTS. 2020. DOI:. 10.1016/j.celrep.2020.107723

63. Intellectual disability-associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs. Jing Li(1,2);Yan-Nan Wang(3);Bei-Si Xu(4);Ya-Ping Liu(5);Mi Zhou(1);Tao Long(1);Hao Li(1);Han Dong(1);Yan Nie(3);Peng R. Chen(5);En-Duo Wang(1,2);Ru-Juan Liu(2). EMBO REPORTS. 2020. DOI:. -

64. Building vertically-structured, high-performance electrodes by interlayer-confined reactions in accordion-like, chemically expanded graphite. Dong, Lei(1,2,3,4,6);Zhang, Long(1,2);Lin, Shan(1,2,8);Chen, Zhongxin(3,4,5);Wang, Yannan(7);Zhao, Xiaoxu(3,4,5);Wu, Tianqi(1,2);Zhang, Jiajia(1,2);Liu, Wei(6);Lu, Hongbin(1,2);Loh, Kian Ping(3,4,5). NANO ENERGY. 2020. DOI:. 10.1016/j.nanoen.2020.104482

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7. Zhang, Yu#; Zhang, Xuefei#; Ba, Zhaoqing; Liang, Zhuoyi; Dring, Edward W.; Hu, Hongli; Lou, Jiangman; Kyritsis, Nia; Zurita, Jeffrey; Shamim, Muhammad S.; Aiden, Aviva Presser; Aiden, Erez Lieberman; Alt, Frederick W*. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. 2019 Sep 11. ISSN:0028-0836;  

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26. Li B#, Zhou X-H# Yang P-Y, Zhu L, Zhong Y, Cai Z, Jiang B, Cai X, Liu J*, Jiang X*. Photoactivatable Fluorogenic Labeling via Turn-On Click-Like Nitroso-Diene Bioorthogonal Reaction. Advanced Science. 2019 May 2. ISSN:2198-3844;  

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29. Bian Hu#, Yan Zou, Linlin Zhang, Jiaxing Tang, Gabriele Niedermann, Elke Firat, Xingxu Huang*, and Xuekai Zhu*. Nucleofection with Plasmid DNA for CRISPR/Cas9-Mediated Inactivation of Programmed Cell Death Protein 1 in CD133-Specific CAR T Cells. Human Gene Therapy. 2019 Apr 10. ISSN:1557-7422;   

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31. Shi X#, Xiao Z#, Zonta F, Wang W, Wan Y, Li Y, Wang N, Kuang Y, Du M, Dong J, Wang J, Yang G*. Somatic MIWI2 Hinders Direct Lineage Reprogramming From Fibroblast to Hepatocyte. Stem Cells. 2019 Feb 28. ISSN:1066-5099;  

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Martewicz S.*, Luni C.*, Serena E., Pavan P., Chen V. H.-S., Rampazzo A., Elvassore N. (2018) Transcriptomic characterization of a human in vitro model of arrhythmogenic cardiomyopathy under topological and mechanical stimuli. Ann Biomed Eng. doi: 10.1007/s10439-018-02134-8.

Prevedello L., Michielin F., Balcon M., Savio E., Pavan P., Elvassore N. (2018) A novel microfluidic platform for biomechano-stimulations on a chip. Ann Biomed Eng.<.em> doi: 10.1007/s10439-018-02121-z.

Dong, Y.; Rodrigues, M.; Kwon, S.H.; Li, X.; A, S.; Brett, E.A.; Elvassore, N.; Wang, W.; Gurtner, C.G.(2018) ‘Acceleration of diabetic wound regeneration using an in-situ-formed stem cell-based skin substitute’. Advanced Healthcare Materials, 7(17):e1800432. doi: 10.1002/adhm.201800432.

Hu Q., Luni C., Elvassore N. (2018) Microfluidics for secretome analysis under enhanced endogenous signaling. Biochem Bioph Res Co 497(2):480-484 doi: 10.1016/j.bbrc.2018.02.025.

Liu J*, Li J, Li J, Zhu L, Wang S-J, Wei X, Ma P-X* (2018) Delivery of superoxide dismutase using Cys2-His2 zinc-finger proteins. in Methods Mol Biol (Liu J Eds., Humana Press, Totowa) 1867, 113-123.

Liu J*, Liang Y-J, Ren P-L, Gaj T (2018) Manufacturing and delivering genome-editing proteins. in Methods Mol Biol (Liu J Eds., Humana Press, Totowa) 1867, 253-273.

ShanghaiTech Researchers Discover a New Electron Transfer Mechanism from a Mycobacterial Respiratory Supercomplex

Lab of stem cell biology reveals the mechanism of Wnt/β-catenin signaling pathway activation in triple negative breast cancer

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Zonta,F., Buratto, D., Crispino, G., Carrer, A., Bruno, F., Yang, G.,Mammano, F.,* and Pantano, S.,*. Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans. Front. Mol. Neurosci., 31 May 2018. https://doi.org/10.3389/fnmol.2018.00170

Yang, Z., Du, M., Wang, W., Xin, X., Ma, P., Zhang, H., Lerner, R. A., Affinity maturation of an TpoR targeting antibody in full-length IgG form for enhanced agonist activity. Protein engineering, design & selection : PEDS 2018. https://doi.org/10.1093/protein/gzy002

Martewicz S, Gabrel G, Campesan M, Canton M, Di Lisa F, Elvassore N. Live Cell Imaging in Microfluidic Device Proves Resistance to Oxygen/Glucose Deprivation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Anal Chem. 2018 Apr 9. doi: 10.1021/acs.analchem.7b05347.

Piao Z., Wang W., Wei Y., Zonta F., Wan C., Bai J., Wu S., Wang X., Fang J.*, Characterization of an acetohydroxy acid synthase mutant conferring tolerance to imidazolinone herbicides in rice (Oryza sativa). Planta, 2017 Nov 18. doi: 10.1007/s00425-017-2817-2

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Mao D., Dr. Liang Y., Liu Y., Zhou X., Ma J., Prof. Jiang B.*, Prof. Liu J.*, Prof. Ma D.*, Acid-Labile Acyclic Cucurbit[n]uril Molecular Containers for Controlled Release - Angewandte Chemie International Edition DOI: 10.1002/anie.201707164

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Liu H., Saxena A., Sidhu S.S.*, and Wu D.H*. (2017) Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds. Front Immunol 8:38 doi: 10.3389/fimmu.2017.00038.

Han Y.B., Chen L.Q., Li Z., Tan Y.M., Feng Y., and Yang G.Y. (2017) Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase. J Biol Chem  doi: 10.1074/jbc.M116.763821.

Saxena A and Wu D.H*. (2016) Advances in Therapeutic Fc Engineering � Modulation of IgG-Associated Effector Functions and Serum Half-life. Front. Immunol. 7:580. doi: 10.3389/fimmu.2016.00580

Liu J. and Shui S.L. (2016) Delivery methods for site-specific nucleases: Achieving the full potential of therapeutic gene editing. J Control Release 244(Pt A):83-97 doi: 10.1016/j.jconrel.2016.11.014.

Scattolini V., Luni C., Zambon A., Galvanin S., Gagliano O., Ciubotaru C.D., Avogaro A., Mammano F., Elvassore N., and Fadini G.P. (2016) Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures. Diabetes Ther 7(4):679-693 doi: 10.1007/s13300-016-0210-y.

Ceriani F., Pozzan T., and Mammano F. (2016) Critical role of ATP-induced ATP release for Ca2+ signaling in nonsensory cell networks of the developing cochlea. Proc Natl Acad Sci U S A 113(46):E7194-E7201 doi: 10.1073/pnas.1616061113.

Cali T., Frizzarin M., Luoni L., Zonta F., Pantano S., Cruz C., Bonza M.C., Bertipaglia I., Ruzzene M., De Michelis M.I., Damiano N., Marin O., Zanni G., Zanotti G., Brini M., Lopreiato R., and Carafoli E. (2016) The ataxia related G1107D mutation of the plasma membrane Ca2+ ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process. Biochim Biophys Acta 1863(1):165-173 doi: 10.1016/j.bbadis.2016.09.007.

Gaj T., Sirk S.J., Shui S.-l., and Liu J. (2016) Genome-Editing Technologies: Principles and Applications. Cold Spring Harbor Perspectives in Biology:a023754 doi: 10.1101/cshperspect.a023754.

Orlandini E.*, Baiesi M., Zonta F. (2016) How Local Flexibility Affects Knot Positioning in Ring Polymers. Macromolecules (online)  doi: 10.1021/acs.macromol.6b00712.

Wang W*, Ma P*, Dong H, Krause HJ, Zhang Y, Willbold D, Offenhaeusser A, Gu Z.(2016) A Magnetic Nanoparticles Relaxation Sensor for Protein-Protein Interaction Detection at Ultra-Low Magnetic Field. Biosens Bioelectron. 80:661-665. doi: 10.1016/j.bios.2016.02.037.

Zhang H., Du M., Xie J., Liu X., Sun J., Wang W., Xin X., Possani L.D., Yea K., and Lerner R.A. (2016) Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries. Angew Chem Int Ed Engl  doi: 10.1002/anie.201603052.

Liu S.S., Wei X., Ji Q., Xin X., Jiang B*., and Liu J*. (2016) A facile and efficient transposon mutagenesis method for generation of multi-codon deletions in protein sequences. J Biotechnol 227:27-34 doi: 10.1016/j.jbiotec.2016.03.038.

Gagliano O., Elvassore N., and Luni C. (2016) Microfluidic technology enhances the potential of human pluripotent stem cells. Biochem Biophys Res Commun  473(3):683-687 doi: 10.1016/j.bbrc.2015.12.058.

Chen H., Han C., Wu J., Liu X., Zhan Y., Chen J., Chen Y., Gu R., Zhang L., Chen S., Jia J., Zhen X., Zheng L.T., and Jiang B. (2016) Accessible Method for the Development of Novel Sterol Analogues with Dipeptide-like Side Chains That Act as Neuroinflammation Inhibitors. ACS Chem Neurosci 7(3):305-315 doi: 10.1021/acschemneuro.5b00256.

Wang Z., Liu N., Shi S., Liu S., and Lin H. (2016) The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. J Biol Chem  doi: 10.1074/jbc.M116.723239.

Peng J.C., Valouev A., Liu N., and Lin H. (2016) Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins. Nat Genet 48(3):283-291 doi: 10.1038/ng.3486.

Folda A., Citta A., Scalcon V., Cali T., Zonta F., Scutari G., Bindoli A., and Rigobello M.P. (2016) Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State. Sci Rep 6:23071 doi: 10.1038/srep23071.