实验室

  王权 博士

助理教授 课题组长

所在学院 免疫化学研究所

              生命科学与技术学院

研究方向 微生物生物能量代谢系统组成与结构；真核细胞线粒体与天然免疫；冷冻电子显微学

联系方式  wangq@@shanghaitech.edu.cn


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个人简介

2009年本科毕业于南开大学信息技术与科学学院；

2014年博士毕业于南开大学生命科学学院；

2014年至2018年在中国科学院生物物理研究所任助理研究员；

2014年至2015年在牛津大学牛津粒子成像中心访问；

2018年至2019年在中国科学院生物物理研究所任副研究员；

2019年至2020年在中国科学院生物物理研究所任研究员、课题组长；

2020年2月加入上海科技大学生命科学与技术学院/免疫化学研究所任助理教授、研究员。


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主要研究内容

致力于利用冷冻电子显微等成像技术，在多尺度下研究结核分枝杆菌、幽门螺旋杆菌等病原微生物能量代谢系统的分子组成、结构特征与功能机制，以及真核细胞“能量工厂”-线粒体在调节宿主天然免疫应对病原菌感染过程中的作用。同时，亦通过干预生物能量代谢系统，开展抗耐药菌和抗肿瘤的药物筛选与研发工作。相关成果在Science、PNAS等国际期刊发表。


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代表性论文

     Structural Biology

  1. Wang Q*, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P*, Rao Z* (2020). Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell. doi: https://doi.org/10.1016/j.cell.2020.05.034. [Representative Publication, Co-first Author]   

  2. Lu Zhang#; Yao Zhao#; Yan Gao; Lijie Wu; Ruogu Gao; Qi Zhang; Yinan Wang; Chengyao Wu; Fangyu Wu; Sudagar S. Gurcha; Natacha Veerapen; Sarah M. Batt; Wei Zhao; Ling Qin; Xiuna Yang; Manfu Wang; Yan Zhu; Bing Zhang; Lijun Bi; Xian’en Zhang; Haitao Yang; Luke W. Guddat; Wenqing Xu; Quan Wang*; Jun Li*; Gurdyal S. Besra*; Zihe Rao*, Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol, Science, eaba9102 (2020) doi:10.1126/science.aba9102. [Representative Publication, Co-corresponding Author]

  3. Yan Gao#; Liming Yan1#; Yucen Huang#; Fengjiang Liu#; Yao Zhao;  Lin Cao; Tao Wang; Qianqian Sun; Zhenhua Ming; Lianqi Zhang; Ji Ge; Litao Zheng; Ying Zhang; Haofeng Wang; Yan Zhu; Chen Zhu; Tianyu Hu; Tian Hua; Bing Zhang; Xiuna Yang; Jun Li; Haitao Yang; Zhijie Liu; Wenqing Xu; Luke W. Guddat; Quan Wang*; Zhiyong Lou*; Zihe Rao*, Structure of the RNA-dependent RNA polymerase from COVID-19 virus, Science, eabb7498 (2020) doi:10.1126/science.abb7498. [Representative Publication, Co-corresponding Author]

  4. Hongri Gong#; Jun Li#; Ao Xu#; Yanting Tang; Wenxin Ji; Ruogu Gao; Shuhui Wang; Lu Yu; Changlin Tian; Jingwen Li; Hsin Yung Yen; Sin Man Lam; Guanghou Shui; Xiuna Yang; Yuna Sun; Xuemei Li; Minze Jia; Cheng Yang; Biao Jiang; Zhiyong Lou; Carol V Robinson; Luet Lok Wong; Luke W Guddat; Fei Sun*; Quan Wang*; Zihe Rao*, An electron transfer path connects subunits of a mycobacterial respiratory supercomplex , Science, 2018.10.25, 362(6418): 0~eaat8923 [Representative Publication, Co-corresponding Author]

  5. Wenxia Liu#; Aijun Liu; Hailong Gao; Quan Wang; Limin Wang; Eberhard Warkentin; Zihe Rao; Hartmut Michel*; Guohong Peng*, Structural properties of the peroxiredoxin AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus, Biochimica et Biophysica Acta-General Subjects, 2018.12, 1862(12): 2797~2805

  6. Kotecha Abhay#; Wang Quan; Dong Xianchi; Ilca Serban L; Ondiviela Marina; Zihe Rao; Seago Julian; Charleston Bryan; Fry Elizabeth E; Abrescia Nicola G A; Springer Timothy A*; Huiskonen Juha T*; Stuart David I*, Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus, Nature Communications, 2017.05.23, 8: 0~15408

  7. Dang, Minghao#; Wang, Xiangxi; Wang, Quan; Wang, Yaxin; Lin, Jianping; Sun, Yuna; Li, Xuemei; Zhang, Liguo; Lou, Zhiyong; Wang, Junzhi; Rao, Zihe*, Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71., Protein & Cell, 2014.9, 5(9): 692~703

  8. Li, Baobin#; Wang, Quan#; Pan, Xijiang; Fernandez de Castro, Isabel; Sun, Yuna; Guo, Yu; Tao, Xinwei; Risco, Cristina; Sui, Sen-Fang; Lou, Zhiyong*, Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation., Proceedings of the National Academy of Sciences of the United States of America, 2013.05.28, 110(22): 9048~9053 [Representative Publication, Co-first Author]

  9. Chen, Qingfeng#; Chen, Xiangsong#; Wang, Quan; Zhang, Faben; Lou, Zhiyong*; Zhang, Qifa*; Zhou, Dao-Xiu*, Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice., PLoS Genetics, 2013, 9(1)

  10. Chen, Qingfeng#; Wang, Quan; Xiong, Lizhong*; Lou, Zhiyong*, A structural view of the conserved domain of rice stress-responsive NAC1., Prot ein Cell, 2011.1, 2(1): 55~63

  11. Wang, Hui#; Morita, Masahiro; Yang, Xiuna; Suzuki, Toru; Yang, Wen; Wang, Jiao; Ito, Kentaro; Wang, Quan; Zhao, Cong; Bartlam, Mark*; Yamamoto, Tadashi*; Rao, Zihe, Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity., The EMBO Journal, 2010.8.4, 29 (15): 2566~2576

    Drug Discovery

  12. Dong, Jing#; Zhang, Yong; Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Yang, Cheng; Wang, Quan; Li, Xuemei*; Deng, Xuming*, Baicalin inhibits the lethality of Shiga-like toxin 2 in mice., Antimicrobial Agents and Chemotherapy, 2015.11, 59(11): 7054~7060

  13. Cao, Shujuan#; Yu, Liang; Mao, Jingyuan; Wang, Quan; Ruan, Jishou*, Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network., PLos One, 2015, 10(12)

  14. Shanshan Qin#; Yiran Ren#; Xu Fu; Jie Shen; Xin Chen; Quan Wang; Xin Bi; Wenjing Liu; Lixin Li; Guangxin Liang; Cheng Yang; Wenqing Shui*, Multiple ligand detection and affinity measurement by ultrafiltration and mass spectrometry analysis applied to fragment mixture screening, Analytica Chimica Acta, 2015.7.30, 886: 98~106

  15. Chen, Xin#; Qin, Shanshan; Chen, Shuai; Li, Jinlong; Li, Lixin; Wang, Zhongling; Wang, Quan; Lin, Jianping; Yang, Cheng; Shui, Wenqing*, A ligand-observed mass spectrometry approach integrated into the fragment-based lead discovery pipeline., Scientific Reports, 2015, 5: 8361~8361

  16. Dong, Jing#; Zhang, Yong; Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Li, Rui; Yang, Cheng; Wang, Quan; Li, Xuemei; Deng, Xuming*, Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization., Journal of Biological Chemistry, 2015.5.15, 290(20): 12899~12907

  17. Dazhi Liu#; Zhen Tian; Zhihui Yan; Lixin Wu; Yan Ma; Quan Wang; Wei Liu*; Honggang Zhou; Cheng Yang, Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors, Bioorganic & Medicinal Chemistry, 2013.6.1, 21(11): 2960~2967