Research Associate Professor
Laboratory: Lab of Antibody Design
Research Interest: Antibody design and antibody therapy
Email: yeak@@shanghaitech.edu.cn
Biography:Ph.D Life Science, POSTECH, Pohang, Republic of Korea
Postdoctoral Associate, Signaling Proteome Lab, POSTECH, Korea, 2008-2009
Postdoctoral Associate, Sanford-Burnham Medical Research Institute, US, 2009-2012
Senior Scientist, Scripps Korea Antibody Institute, Korea, 2012-2013
Research Associate Professor, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China, (-Visiting Investigator, The Scripps Research Institute, US) 2013-Present
Representative publication:Yea K, Xie J, Zhang H, Zhang W, Lerner RA. ”Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic.” Curr Opin Chem Biol. 2015 Jan 23;26C:1-7. doi: 10.1016/j.cbpa.2015.01.002. [Epub ahead of print] Review.
Kim D, Kim J, Yoon JH, Ghim J,
Yea K, Song P, Park S, Lee A, Hong CP, Jang MS, Kwon Y, Park S, Jang MH, Berggren PO, Suh PG, Ryu SH. ”CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice.” Diabetologia. 2014 Jul;57(7):1456-65. doi: 10.1007/s00125-014-3237-5. Epub 2014 Apr 18.
Xie J,
Yea K, Zhang H, Moldt B, He L, Zhu J, Lerner RA. ”Prevention of cell death by antibodies selected from intracellular combinatorial libraries.” Chem Biol. 2014 Feb 20;21(2):274-83. doi: 10.1016/j.chembiol.2013.12.006. Epub 2014 Jan 16.
Yea K, Zhang H, Xie J, Jones TM, Yang G, Song BD, Lerner RA. “Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections.” Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14966-71. doi: 10.1073/pnas.1313671110. Epub 2013 Aug 26.
Zhang H,
Yea K, Xie J, Ruiz D, Wilson IA, Lerner RA. “Selecting agonists from single cells infected with combinatorial antibody libraries.” Chem Biol. 2013 May 23;20(5):734-41. doi: 10.1016/j.chembiol.2013.04.012.
Kim BJ, Lee YS, Lee SY, Park SY, Dieplinger H,
Yea K, Lee SH, Koh JM, Kim GS. “Afamin stimulates osteoclastogenesis and bone resorption via Gi-coupled receptor and Ca2+/calmodulin-dependent protein kinase (CaMK) pathways.” J Endocrinol Invest. 2013 Nov;36(10):876-82. doi: 10.3275/8975. Epub 2013 May 22.
Xie J, Zhang H,
Yea K, Lerner RA. “Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells.” Proc Natl Acad Sci U S A. 2013 May 14;110(20):8099-104. doi: 10.1073/pnas.1306263110. Epub 2013 Apr 23.
