副研究员 共同课题组长（Co-PI） 所在学院 免疫化学研究所 研究方向 病毒及真核生物转录调控 联系方式 zhanghq@@shanghaitech.edu.cn （请删除一个@） 教育背景
2013.09-2016.06 清华大学（导师：柴继杰教授），博士学位
2010.09-2013.06 中国科学院生物物理研究所，硕士学位
2006.09-2010.06 河北工业大学，学士学位 工作经历 2021.07-现在 上海科技大学免疫化学研究所结构生物化学实验室副研究员，Co-PI （2021.09开始） 2017.01-2021.07 上海科技大学免疫化学研究所结构生物化学实验室助理研究员 2016.07-2016.12 上海恒瑞医药有限公司高级研究员 2019.04-2020.09 美国斯坦福大学医学院结构生物学系访问副教授 2017.12-2018.06 美国斯坦福大学医学院结构生物学系访问副教授 研究兴趣 运用分子生物学、生物化学、细胞生物学、结构生物学等方法研究：（1）麻疹病毒、尼帕病毒等非节段负链RNA病毒（nsNSV）RNA复制、转录和动态调控的分子机制及后续抗病毒药物开发；（2）真核生物表观遗传修饰（如乙酰化、去乙酰化、甲基化、去甲基化）及其介导的基因转录调控分子机制。
获得荣誉
2016.06 清华大学-北京大学生命科学联合中心生命科学研究奖
2014.10 清华大学综合优秀奖学金
经费项目
2018.01-2020.12 国家自然科学基金青年项目（项目批准号：31700665）
2022.10-2023.12 山西省重点实验室开放项目（项目批准号：202104010910006）
代表性论文：
1. Wang, Y., Zhao, L., Zhang, Y., Gao, X., Wang, Y., Shi, W., Kornberg, R.D#., and Zhang, H#. (2025). Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition. Cell. doi: 10.1016/j.cell.2025.06.017. (#corresponding author). 2. Wang, Y., Zhao, L., Zhang, Y., Wang, Y., Tang, J., Liu, S., Gao, H., Zhang, X#., Zinzula, L#., Kornberg, R.D#., and Zhang, H#. (2024). Cryo-EM structure of Nipah virus RNA polymerase complex. Science Advances10(50), eadr7116. (#corresponding author). 3. Wang, X., Wang, Y., Liu, S., Zhang, Y., Xu, K., Ji, L., Kornberg, R.D#., and Zhang, H#. (2023). Class I histone deacetylase complex: Structure and functional correlates. Proc Natl Acad Sci U S A 120, e2307598120. (#corresponding author). 4. Ji, L., Zhao, L., Xu, K., Gao, H., Zhou, Y., Kornberg, R.D#., and Zhang, H#. (2022). Structure of the NuA4 histone acetyltransferase complex. Proc Natl Acad Sci U S A 119, e2214313119. (#corresponding author). 5. Zhang, H., Chen, D.H., Mattoo, R.U.H., Bushnell, D.A., Wang, Y., Yuan, C., Wang, L., Wang, C., Davis, R.E., Nie, Y., Kornberg, R.D. (2021). Mediator structure and conformation change. Molecular Cell 81, 1781-1788 e1784. 6. Wang, Y., Graham, L.A., Han, Z., Eves, R., Gruneberg, A.K., Campbell, R.L., Zhang, H#., and Davies, P.L.# (2020). Carrot 'antifreeze' protein has an irregular ice-binding site that confers weak freezing point depression but strong inhibition of ice recrystallization. Biochem J 477, 2179-2192. (#corresponding author). 7. Wang, Y., Zhang, F., Nie, Y#., Shang, G#., and Zhang, H#. (2019). Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis. Biochem Biophys Res Commun 516, 540-545. (#corresponding author). 8. Zhang, H*., Lin, X*., Han, Z., Qu, L.J., and Chai, J. (2016). Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs. Cell Res 26, 543-555. (*co-first author). 9. Zhang, H*., Lin, X*., Han, Z., Wang, J., Qu, L.J., and Chai, J. (2016). SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular Development. Mol Plant 9, 1406-1414. (*co-first author). 10. Zhang, H., Han, Z., Song, W., and Chai, J. (2016). Structural Insight into Recognition of Plant Peptide Hormones by Receptors. Mol Plant 9, 1454-1463. 11. Lu, D*., Shang, G*., Zhang, H*., Yu, Q*., Cong, X., Yuan, J., He, F., Zhu, C., Zhao, Y., Yin, K., et al. (2014). Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism. Mol Microbiol 92, 1092-1112. (*co-first author). 12. Zhang, X., Liu, W., Nagae, T.T., Takeuchi, H., Zhang, H., Han, Z., Higashiyama, T., and Chai, J. (2017). Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun 8, 1331. 13. Ma, C., Liu, Y., Bai, B., Han, Z., Tang, J., Zhang, H., Yaghmaiean, H., Zhang, Y., and Chai, J. (2017). Structural basis for BIR1-mediated negative regulation of plant immunity. Cell Res 27, 1521-1524. 14. Wu, Z., Liang, S., Song, W., Lin, G., Wang, W., Zhang, H., Han, Z., and Chai, J. (2017). Functional and Structural Characterization of a Receptor-Like Kinase Involved in Germination and Cell Expansion in Arabidopsis. Front Plant Sci 8, 1999. 15. Ma, R., Han, Z., Hu, Z., Lin, G., Gong, X., Zhang, H., Nasrallah, J.B., and Chai, J. (2016). Structural basis for specific self-incompatibility response in Brassica. Cell Res 26, 1320-1329. 16. Song, W., Liu, L., Wang, J., Wu, Z., Zhang, H., Tang, J., Lin, G., Wang, Y., Wen, X., Li, W., et al. (2016). Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Res 26, 674-685. 17. Liu, S., Wang, J., Han, Z., Gong, X., Zhang, H., and Chai, J. (2016). Molecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP.Structure 24, 1192-1200. 18. Wang, J., Li, H., Han, Z., Zhang, H., Wang, T., Lin, G., Chang, J., Yang, W., and Chai, J. (2015). Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature 525, 265-268. 19. Song, W., Wang, J., Han, Z., Zhang, Y., Zhang, H., Wang, W., Chang, J., Xia, B., Fan, S., Zhang, D., et al. (2015). Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nat Struct Mol Biol 22, 782-787. 20. Tang, J., Han, Z., Sun, Y., Zhang, H., Gong, X., and Chai, J. (2015). Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1. Cell Res 25, 110-120. 21. Albert, I., Bohm, H., Albert, M., Feiler, C.E., Imkampe, J., Wallmeroth, N., Brancato, C., Raaymakers, T.M., Oome, S., Zhang, H., et al. (2015). An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity. Nat Plants 1, 15140.
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