副研究员 共同课题组长（Co-PI） 所在学院 免疫化学研究所 研究方向 中介体复合物及组蛋白翻译后修饰介导的转录调控 联系方式 zhanghq@@shanghaitech.edu.cn （请删除一个@） 教育背景
2013.09-2016.06 清华大学（导师：柴继杰教授），博士学位
2010.09-2013.06 中国科学院生物物理研究所，硕士学位
2006.09-2010.06 河北工业大学，学士学位 工作经历 2021.07-现在 上海科技大学免疫化学研究所结构生物化学实验室副研究员，Co-PI （2021.09开始） 2017.01-2021.07 上海科技大学免疫化学研究所结构生物化学实验室助理研究员 2016.07-2016.12 上海恒瑞医药有限公司高级研究员 2019.04-2020.09 美国斯坦福大学医学院结构生物学系访问副教授 2017.12-2018.06 美国斯坦福大学医学院结构生物学系访问副教授
研究兴趣
运用生物化学、结构生物学及单分子方法研究转录起始过程中介体复合物的转录调控分子机制，以及转录起始复合物的动态组装及解聚过程。我同时会对组蛋白翻译后修饰相关复合物开展结构生物学研究。
获得荣誉
2016.06 清华大学-北京大学生命科学联合中心生命科学研究奖
2014.10 清华大学综合优秀奖学金
代表性论文： 1. Wang, X., Wang, Y., Liu, S., Zhang, Y., Xu, K., Ji, L., Kornberg, R.D#., and Zhang, H#. (2023). Class I histone deacetylase complex: Structure and functional correlates. Proc Natl Acad Sci U S A 120, e2307598120. (#corresponding author). 2. Ji, L., Zhao, L., Xu, K., Gao, H., Zhou, Y., Kornberg, R.D#., and Zhang, H#. (2022). Structure of the NuA4 histone acetyltransferase complex. Proc Natl Acad Sci U S A 119, e2214313119. (#corresponding author). 3. Zhang, H*., Chen, D.H., Mattoo, R.U.H., Bushnell, D.A., Wang, Y., Yuan, C., Wang, L., Wang, C., Davis, R.E., Nie, Y., Kornberg, R.D. (2021). Mediator structure and conformation change. Mol Cell 81, 1781-1788 e1784. (*first author). 4. Wang, Y., Graham, L.A., Han, Z., Eves, R., Gruneberg, A.K., Campbell, R.L., Zhang, H#., and Davies, P.L.# (2020). Carrot 'antifreeze' protein has an irregular ice-binding site that confers weak freezing point depression but strong inhibition of ice recrystallization. Biochem J 477, 2179-2192. (#corresponding author). 5. Wang, Y., Zhang, F., Nie, Y#., Shang, G#., and Zhang, H#. (2019). Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis. Biochem Biophys Res Commun 516, 540-545. (#corresponding author). 6. Zhang, H *., Lin, X *., Han, Z., Qu, L.J., and Chai, J. (2016). Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs. Cell Res 26, 543-555. (*co-first author). 7. Zhang, H *., Lin, X *., Han, Z., Wang, J., Qu, L.J., and Chai, J. (2016). SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular Development. Mol Plant 9, 1406-1414. (*co-first author). 8. Zhang, H *., Han, Z., Song, W., and Chai, J. (2016). Structural Insight into Recognition of Plant Peptide Hormones by Receptors. Mol Plant 9, 1454-1463. (*first author). 9. Lu, D*., Shang, G*., Zhang, H *., Yu, Q*., Cong, X., Yuan, J., He, F., Zhu, C., Zhao, Y., Yin, K., et al. (2014). Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism. Mol Microbiol 92, 1092-1112. (*co-first author). 10. Zhang, X., Liu, W., Nagae, T.T., Takeuchi, H., Zhang, H., Han, Z., Higashiyama, T., and Chai, J. (2017). Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun 8, 1331. 11. Ma, C., Liu, Y., Bai, B., Han, Z., Tang, J., Zhang, H., Yaghmaiean, H., Zhang, Y., and Chai, J. (2017). Structural basis for BIR1-mediated negative regulation of plant immunity. Cell Res 27, 1521-1524. 12. Wu, Z., Liang, S., Song, W., Lin, G., Wang, W., Zhang, H., Han, Z., and Chai, J. (2017). Functional and Structural Characterization of a Receptor-Like Kinase Involved in Germination and Cell Expansion in Arabidopsis. Front Plant Sci 8, 1999. 13. Ma, R., Han, Z., Hu, Z., Lin, G., Gong, X., Zhang, H., Nasrallah, J.B., and Chai, J. (2016). Structural basis for specific self-incompatibility response in Brassica. Cell Res 26, 1320-1329. 14. Song, W., Liu, L., Wang, J., Wu, Z., Zhang, H., Tang, J., Lin, G., Wang, Y., Wen, X., Li, W., et al. (2016). Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell Res 26, 674-685. 15. Liu, S., Wang, J., Han, Z., Gong, X., Zhang, H., and Chai, J. (2016). Molecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP.Structure 24, 1192-1200. 16. Wang, J., Li, H., Han, Z., Zhang, H., Wang, T., Lin, G., Chang, J., Yang, W., and Chai, J. (2015). Allosteric receptor activation by the plant peptide hormone phytosulfokine. Nature 525, 265-268. 17. Song, W., Wang, J., Han, Z., Zhang, Y., Zhang, H., Wang, W., Chang, J., Xia, B., Fan, S., Zhang, D., et al. (2015). Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nat Struct Mol Biol 22, 782-787. 18. Tang, J., Han, Z., Sun, Y., Zhang, H., Gong, X., and Chai, J. (2015). Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1. Cell Res 25, 110-120. 19. Albert, I., Bohm, H., Albert, M., Feiler, C.E., Imkampe, J., Wallmeroth, N., Brancato, C., Raaymakers, T.M., Oome, S., Zhang, H., et al. (2015). An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity. Nat Plants 1, 15140. 20. Wang, J., Wang, W., Song, W., Han, Z., Zhang, H., Chai, J., Wang, H., and Wang, J. (2015). An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data. Protein Cell 6, 919-923.
|
