刘三宏 博士

发布者:冯明静发布时间:2019-11-14浏览次数:226

  刘三宏 博士

Research Associate Professor
Laboratory: Lab of stem cell
Research Interest: Molecular mechanism of tumor signaling pathway regulation; Non-coding RNA in cancer.

Email: liush@@shanghaitech.edu.cn

Tel: +86-21-20685133


Biography:

2015.3-present
Research associate professor, Molecular Cell Biology
Shanghai Institute for Advanced Immunochemical studies (SIAIS), ShanghaiTech University.
2012.12-2015.2
Associate professor, Co-PI, Molecular Cell Biology
Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine.
2010. 06-2012.12
Postdoc, Molecular Cell Biology
Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine.
2008. 02-2010. 05
Assistant Professor, Molecular Cell Biology
Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

2004-2007, Ph.D.
Graduate School of Chinese Academy of Agricultural Sciences, Beijing, China
2001-2004, M.S.
Graduate School of Chinese Academy of Agricultural Sciences, Beijing, China
1997-2001, B.S.
Henan Agricultural University, Henan, China


Selected Grants, Awards, & Honors:
1. National Natural Science Foundation of China(国家自然科学基金面上项目) (Grant No.: 81772798; 2018.01-2021.12).
2. The best poster award of the ShanghaiTech-SIAIS bioforum, 2016.
3. SANOFI-SIBS young scientist scholarship, 2014.

4. Wang Kuancheng International Conference Fellowship, 2013.
5. SANOFI-SIBS Post-doctoral Fellowship, 2012.
6. China Post-doctoral Fellowship, 2011.
7. Talent young scientist of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2009.


Publications:

1.      Xi Chen#, Chen Wang#, Yuhang Jiang, Qi Wang, Haohao Zhang, Yongxu Zhao, Yu Tao, Yiming Hu, Cuifeng Li, Junhaohui Huo, Deji Ye, Dandan Liu, Wenxia Jiang, Lingling Li, Mingliang Wang*, Sanhong Liu*, Xiaoren Zhang*. Bcl-3 promotes Wnt signaling through sustaining the acetylation of β-catenin at lysine 49 in colorectal cancer. Signal Transduction and Targeted Therapy, 2019 (In press).

2.      Xinying Xue#, Chen Wang#, Zhiqiang Xue#, Jiaxin Wen, Jun Han, Xidong Ma, Xuelei Zang, Hui Deng, Rui Guo, Idorenyin Polycarp Asuquo, Chong Qin, Haijiao Wang, Quansheng Gao*, Sanhong Liu*, Jianxin Wang*. Exosomal miRNA profiling before and after surgery revealed potential diagnostic and prognostic markers for lung adenocarcinoma. Acta Biochimica et Biophysica Sinica, 2019 (In press).

3.      Yuhang Jiang#, Qian Wu#, Jiang Y#, Li C#, Wu Q, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F, Zhang X.*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nature Communications, 2019 Jul 3;10(1):2935. doi: 10.1038/s41467-019-11002-5.

4.      Qi Wang#, Chen X#, Jiang Y, Liu S, Liu H, Sun X, Zhang H, Liu Z, Tao Y, Li C, Hu Y, Liu D, Ye D, Liu Y, Wang M, Zhang X*. The Histone H3 Lysine-27 trimethylation regulates chemosensitivity in colorectal cancer by targeting β-catenin. J Mol Cell Biol, 2019 May 8. pii: mjz032. doi: 10.1093/jmcb/mjz032.

5.      Sanhong Liu*#, Zifeng Wang#, Zukai Liu#, Shuo Shi, Zhaoran Zhang, Jiawei Zhang, Haifan Lin*. MiR-221/222 activate the Wnt/β-catenin signaling to promote triple negative breast cancer. J Mol Cell Biol, 2018 Aug 1; 10(4):302-315. doi: 10.1093/jmcb/mjy041.(Cover story)

6.      Yu Tao#, Zhanjie Liu#, Yingyong Hou#, Shouli Wang, Sanhong Liu, Yuhang Jiang, Dan Tan, Qiulin Ge, Cuifeng Li, Yiming Hu, Zhi Liu, Xi Chen, Qi Wang, Mingliang Wang*, and Xiaoren Zhang*. Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally up-regulating Bcl-3. Oncogene, 2018 Jul 4; doi: 10.1038/s41388-018-0363-4.

7.      Junhaohui Huo, Xi Chen, Haohao Zhang, Sanhong Liu, Xiaoren Zhang. Bcl-3 Promotes Proliferation and Chemosensitivity in BL1 Subtype of TNBC Cells. Acta Biochimica et Biophysica Sinica, 2018 Oct 5; doi: 10.1093/abbs/gmy117.

8.      Ran Chen#, Lunshan Wang#, Sanhong Liu, Xi Chen, Yiming Hu, Hanshao Liu, Haohao Zhang, Yuhang Jiang, Lingling Li, Dandan Liu, Xiaorong Pan, Lixin Wei, Xiaoren Zhang. Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease. Oncotarget, 2017 Oct 9; 8(57):97206-97216.

9.      Pengfei Chen#, Haohao Zhang#, Xiaohua Sun, Yiming Hu, Wenxia Jiang, Zhanjie Liu, Sanhong Liu, Xiaoren Zhang. MiR-449a modulates medullary thymic epithelial cell differentiation. Scientific Reports, 2017 Nov 21; 7(1):15915. doi: 10.1038/s41598-017-16162-2.

10.   Yingjie Zhu#, Guangyong Zheng#, Huichao Wang#, Yudong Jia, Ying Zhang, Yanfeng Tang, Wenlong Li, Yanan Fan, Xiaodong Zhang*, Youwen Liu*, Sanhong Liu*. Downregulated miR-29a/b/c during Contact Inhibition Stage Promote 3T3-L1 Adipogenesis by Targeting DNMT3A. PLoS One, 2017: 12(1): e0170636. doi: 10.1371/journal.pone.0170636.

11.   Qiulin Ge#, Sanhong Liu#, Zhihong Ai, Minfang Tao, Li Ma et alShanyun Wen, Miao Dai, Fei Liu, Hanshao Liu, Rongzhen Jiang, Zhuowei Xue, Yuhang Jiang, Xiaohua Sun, Yiming Hu, Yongxu Zhao, Xi Chen, Yu Tao, Xiaolu Zhu, Wenjing Ding, Bingqing Yang, Yufang Shi, Xiaoren Zhang, and Yincheng Teng. RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis.Cell Death & Disease, 2016, doi:10.1038/cddis.2016.309.

12.   Xi Chen#, Xinwei Cao#, Xiaohua Sun, Rong Lei, Pengfei Chen, Yongxu Zhao, Yuhang Jiang, Jie Yin, Ran Chen, Deji Ye, Qi Wang, Zhanjie Liu, Sanhong Liu, Chunyan Cheng, Jie Mao, Yingyong Hou, Mingliang Wang, Ulrich Siebenlist, Y Eugene Chin, Ying Wang, Liu Cao, Guohong Hu and Xiaoren Zhang. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death & Disease, 2016, 7, e2508; doi:10.1038/cddis.2016.405.

13.   Xinying Xue, Yuxia Liu, Yong Wang, Mingming Meng, Xuefeng Zang, Sheng Zhao,Xiaohua Sun, Kaifei Wang, Lei Cui, Lei Pan, Sanhong Liu*. MiR-21 and MiR-155 Promote Non-small Lung Cancer Progression by Targeting SOCS1, SOCS6, and PTEN. Oncotarget, 2016, doi: 10.18632/oncotarget.13022.

14.   Sun Xiaohua#, Liu Sanhong#, Chen Pengfei, Fu Da Hou Yingyong, Hu Jin, Liu Zhi, Jiang Yuhang, Cao Xinwei, Cheng Chunyan, Chen Xi, Tao Yu, Li Cuifeng, Hu Yiming, Liu Zhanjie, Zhan Yu, Mao Jie, Wang Qi, Ma Yushui, Cong Xianlin, Sun Ran, Shi Yufang, Wang Mingliang, Zhang Xiaoren. MiR-449a inhibits colorectal cancer progression by targeting SATB2. Oncotarget, 2016, doi: 10.18632/oncotarget.10900.

15.   Wang Zifeng, Liu Na, Shi Shuo, Liu Sanhong*, Lin Haifan*. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. Journal of Biological Chemistry, 2016, doi: 10.1074/jbc.M116.723239. Evaluated by faculty of 1000.

16.   Zhi Liu, Wei Cao, Longxia Xu, Xi Chen, Yu Zhan, Qian Yang, Sanhong Liu, Pengfei Chen, Yuhang Jiang, Xiaohua Sun, Yu Tao, Yiming Hu, Cuifeng Li, Qi Wang, Ying Wang, Charlie Degui Chen, Yufang Shi, and Xiaoren Zhang. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol, 2015, doi:10.1093/jmcb/mjv022.

17.   Sanhong Liu#, Xiaohua Sun#, Mingliang Wang#, Yingyong Hou, Yu Zhan, Yuhang Jiang, Zhanjie Liu, Xinwei Cao, Pengfei Chen, Zhi Liu, Xi Chen, Yu Tao, Chen Xu, Jie Mao, Chunyan Cheng, Cuifeng Li, Yiming Hu, Lunshan Wang, Y Eugene Chin, Yufang Shi, Ulrich Siebenlist, Xiaoren Zhang. A microRNA 221– and 222–Mediated Feedback Loop Maintains Constitutive Activation of NFκB and STAT3 in colon Cancer Cells. Gastroenterology, 2014, 147: 847-859.

18.   Yingjie Zhu, Xiaodong Zhang, Xingpo Ding, Huichao Wang, Xiantao Chen, Hanzheng Zhao, Yudong Jia, Sanhong Liu* and Youwen Liu*. MiR-27 inhibits adipocyte differentiation via suppressing CREB expression. Acta Biochimica et Biophysica Sinica,2014, 46: 590-596.

19.   Zhanjie Liu#, Yuhang Jiang#, Yingyong Hou#, Yiming Hu, Xinwei Cao, Yu Tao, Chen Xu, Sanhong Liu, Shouli Wang, Lunshan Wang, Yufang Shi, Ulrich Siebenlist, Xiaoren Zhang. Bcl-3 promotes cell cycle progression through stabilizing c-Myc protein stability in human colon cancer.J Mol Cell Biol, 2013, 5(4):280-282.

20.   Sanhong Liu, Ying Yang and Jiarui Wu. TNFα-induced miR-155 up-regulation inhibits adipogenesis by down-regulating early adipogenic transcription factors. Biochemical and Biophysical Research Communications, 2011, 414: 618-624.

21.   Yongsheng Guan, Rachid Serraj, Sanhong Liu, Jianlong Xu, Jauhar Ali, Wensheng Wang, Elec Venus and Zhikang Li. Simultaneously improving drought tolerance and yield potential - a case study of rice. Journal of Experimental Botany, 2010, 61 (15): 4145-4156.

22.   Sanhong Liu#, Binying Fu#, Huaxue Xu, Linhua Zhu, Huqu Zhai, Zhikang Li. Cell death in response to osmotic and salt stresses in two rice (Oryza sativa L.) ecotypes. Plant Science, 2007, 172: 897-902.

23.   Liu Sanhong, Wang Kunbo, Song Guoli, Wang Chunying, Liu Fang, Li Shaohui, Zhang Xiangdi, Wang Yuhong. Primary investigation on GISH-NOR in cotton. Chinese Science Bulletin, 2005, 50 (5): 425-429.

# Co-first authors, * Corresponding author.