Research Associate Professor
Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
Email: xulan@@shanghaitech.edu.cn
Tel: 021-20685598
Laboratory: Lab of Antibody Structure
Research Interest:
1) Protein engineering using structure-based approach and/or directed evolution, mainly focusing on its application in therapeutic protein drug design, and other biologically important process development. These include antibody engineering, API and biologics production process development and optimization.
2) Structure elucidation of immunological important biological processes, for example, Toll-like receptor-agonist and antagonist complexed structure and antibody-antigen complexed structure determination, with the goal to discover efficacious treatment for infectious, autoimmune diseases and cancer.
Biography:
1997 B.S. of Chemistry, Department of Chemistry, Peking University, Beijing, P.R.China
2002 Ph.D. of Chemistry, Department of Chemistry, University of Pennsylvania, Philadelphia, U.S.A.
2002-2006 Postdoctoral Fellow, Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, U.S.A.
2006-2008 Senior Scientist, Bioverdant, San Diego, CA, U.S.A.
2008-2012 Scientist, Amyris Biotechnology, Emeryville, CA, U.S.A.
2015-present Research Associate Professor, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China
Selected Patents:
Zhao, L.; Xu, L.; Westfall, P.; Main, A. (2012). Farnesyl pyrophosphate utilization screening method for use in the screening of terpene synthase variants. US 20120196315 A1 20120802.
Tucker, J. L., Xu, L., Yu, W., Scott, R.W., Zhao, L. and Ran, N. (2009). Chemoenzymatic processes for preparation of levetiracetam. WO 2009/009117.
Representative Publications:
1. Meadows, A.L., Hawkins, K.M., Tsegaye, Y., Antipov, E., Kim, Y., Raetz, L., Dahl, R.H., Tai, A., Mahatdejkul-Meadows, T., Xu, L.,Zhao, L., Dasika, M.S., Murarka, A., Lenihan, J., Eng, D., Leng, J.S., Liu, C.L., Wenger, J.W., Jiang, H., Chao, L., Westfall, P., Lai, J., Ganesan, S., Jackson, P., Mans, R., Platt, D., Reeves, C.D., Saija, P.R., Wichmann, G., Holmes, V.F., Benjamin, K., Hill, P.W., Gardner, T.S. and Tsong, A.E．(2016). Rewriting yeast central carbon metabolism for industrial isoprenoid production. Nature 537, 694-697.
2. Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G. P., Chenglong Li, C. L., Olson, A. J., Boger, D. L., and Wilson, I. A. (2007) Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase. J. Biol. Chem. 282, 13033-13046
3. Xu, L., Benson, S. D and Burnett, R. M. (2007) Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon. J. Struct. Biol. 157, 424-431
4. DeMartino, J. K., Hwang I, Xu, L., Wilson, I. A. and Boger, D. L. (2006) Discovery of a Potent, Nonpolyglutamatable Inhibitor of Glycinamide Ribonucleotide Transformylase. J. Med. Chem., 49, 2998-3002
5. Xu, L., Li, C., Olson, A. J. and Wilson, I. A. (2004). Crystal structure of avian AICAR transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. J. Biol. Chem. 279, 50555-50565
6. Li, C., Xu, L., Wolan, D. W., Wilson, I. A., and Olson, A. J. (2004). Successful virtual screening for human AICAR transformylase inhibitors against NCI diversity set using AutoDock. J. Med. Chem. 47, 6681-6690
7. Xu, L., Benson, S.D., Butcher, S.J., Bamford, D.H. and Burnett, R.M. (2003). The receptor binding protein P2 of PRD1, a virus targeting antibiotic-resistant bacteria, has novel fold suggesting multiple functions. Structure 11, 309-322
8. Xu, L., Butcher, S.J., Benson, S.D., Bamford, D.H. and Burnett, R.M. (2000). Crystallization and preliminary X-ray analysis of receptor-binding protein P2 of bacteriophage PRD1. J. Struct. Biol. 131, 159-163
