特聘教授 课题组长
所在学院 免疫化学研究所
研究方向 病毒学，免疫学，疫苗，抗体
联系方式 zhaojc@shanghaitech.edu.cn zhaojincun@gird.cn
教育经历
1997/09—2002/07，北京大学，学士
2002/09—2007/07，北京大学，博士
工作经历
2007/08—2012/08，University of Iowa，博士后
2012/09—2015/09，University of Iowa，助理研究科学家
2015/09—至今，广州医科大学，教授
2021/11—至今，上海科技大学生命科学与技术学院、免疫化学研究所，特聘教授
研究内容
长期从事人类新发突发呼吸系统传染病致病机制及相关预防、治疗方法研究。具体包括：
1. 呼吸系统病毒进化变异及与宿主相互作用机制研究
2. 呼吸系统病毒感染天然和获得性免疫应答研究
3. 呼吸系统传染病疫苗和抗体药物研发
奖励
1.《高被引科学家》，科睿唯安，2021年
2.国家杰出青年科学基金获得者，2020年
3.长江学者特岗，2020年
4.享受政府特殊津贴，2020年
5.《全国创新争先奖》，排名第三，2020年
代表性论文（#第一作者，*通讯作者）
1. Sun J#, Zhuang Z#, Zheng J#, Li K#, Wong RL#, Liu D#, Huang J#, He J#, Zhu A#, Zhao J#, Li X#, Xi Y#, Chen R, Alshukairi AN, Chen Z, Zhang Z, Chen C, Huang X, Li F, Lai X, Chen D, Wen L, Zhuo J, Zhang Y, Wang Y, Huang S, Dai J, Shi Y, Zheng K, Leidinger MR, Chen J, Li Y, Zhong N, Meyerholz DK, McCray PB Jr*, Perlman S*, Zhao J*. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 2020 Aug 6;182(3):734-743.e5.
2. Mok CKP#, Zhu A#, Zhao J#, Lau EHY, Wang J, Chen Z, Zhuang Z, Wang Y, Alshukairi AN, Baharoon SA, Wang W, Tan W, Liang W, Oladipo JO, Perera RAPM, Kuranga SA, Peiris M*, Zhao J*. T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study. Lancet Infect Dis. 2021 Mar;21(3):385-395.
3. Zhao J#, Alshukairi AN#, *, Baharoon SA, Ahmed WA, Bokhari AA, Nehdi AM, Layqah LA, Alghamdi MG, Al Gethamy MM, Dada AM, Khalid I, Boujelal M, Al Johani SM, Vogel L, Subbarao K, Mangalam A, Wu C, Ten Eyck P, Perlman S*, Zhao J*. Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol. 2017 Aug 4;2(14). pii: eaan5393.
4. Wang Y#, Zhang L#, Sang L#, Ye F#, Ruan S#, Zhong B#, Song T#, Alshukairi AN#, Chen R#, Zhang Z, Gan M, Zhu A, Huang Y, Luo L, Mok CK, Al Gethamy MM, Tan H, Li Z, Huang X, Li F, Sun J, Zhang Y, Wen L, Li Y, Chen Z, Zhuang Z, Zhuo J, Chen C, Kuang L, Wang J, Lv H, Jiang Y, Li M, Lin Y, Deng Y, Tang L, Liang J, Huang J, Perlman S, Zhong N, Zhao J*, Malik Peiris JS*, Li Y*, Zhao J*. Kinetics of viral load and antibody response in relation to COVID-19 severity. J Clin Invest. 2020 Oct 1;130(10):5235-5244.
5. Zhuang Z#, Lai X#, Sun J#, Chen Z#, Zhang Z#, Dai J#, Liu D#, Li Y#, Li F#, Wang Y, Zhu A, Wang J, Yang W, Huang J, Li X, Hu L, Wen L, Zhuo J, Zhang Y, Chen D, Li S, Huang S, Shi Y, Zheng K, Zhong N, Zhao J*, Zhou D*, Zhao J*. Mapping and role of T cell response in SARS-CoV-2-infected mice. J Exp Med. 2021 Apr 5;218(4):e20202187.
6. Wang Y#, Wang D#, Zhang L#, Sun W#, Zhang Z#, Chen W#, Zhu A#, Huang Y#, Xiao F, Yao J, Gan M, Li F, Luo L, Huang X, Zhang Y, Wong SS, Cheng X, Ji J, Ou Z, Xiao M, Li M, Li J, Ren P, Deng Z, Zhong H, Xu X, Song T, Mok CKP, Peiris M, Zhong N, Zhao J*, Li Y*, Li J*, Zhao J*. Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients. Genome Med. 2021 Feb 22;13(1):30.
7. Zhang Z#, Zeng E#, Zhang L#, Wang W#, Jin Y#, Sun J#, Huang S#, Yin W#, Dai J, Zhuang Z, Chen Z, Sun J, Zhu A, Li F, Cao W, Li X, Shi Y, Gan M, Zhang S, Wei P, Huang J, Zhong N, Zhong G*, Zhao J*, Wang Y*, Shao W*, Zhao J*. Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo. Cell Discov. 2021 Aug 12;7(1):65.
8. Zhong H#, Wang Y#, Shi Z#, Zhang L#, Ren H#, He W#, Zhang Z#, Zhu A#, Zhao J#, Xiao F#, Yang F, Liang T, Ye F, Zhong B, Ruan S, Gan M, Zhu J, Li F, Li F, Wang D, Li J, Ren P, Zhu S, Yang H, Wang J, Kristiansen K, Tun HM, Chen W, Zhong N, Xu X*, Li YM*, Li J*, Zhao J*. Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients. Cell Discov. 2021 Apr 13;7(1):23.
9. Zhao J#, *, Zhao J#, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S*. Airway Memory CD4 T Cells Orchestrate Protective Immunity against Emerging Human Respiratory Coronaviruses. Immunity. 2016 Jun 21;44(6):1379-91.
10. Zhao J#, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB Jr, Perlman S*. Rapid generation of a mouse model for Middle East Respiratory Syndrome.Proc Natl Acad Sci U S A. 2014 Apr; 111:4970-4975.
11. Zhao J#, Zhao J, Legge K, Perlman S*. Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest. 2011 Dec; 121:4921-4930.
