杨贝 博士

发布者：冯明静发布时间：2019-11-14浏览次数：1064

  杨贝 博士

课题组长, 研究员, 助理教授

Principal Investigator, Tenure-track Assistant Professor 

Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
Email: yangbei@shanghaitech.edu.cn
Tel: 021-20685590
Laboratory: Lab of Pathogenic Biology

Research Interest

Research in our lab focuses on several high-risk infectious diseases and their causative microbes, including respiratory viruses, HIV-1 and plasmodium. We are particularly interested in:

1)identifying novel sites of therapeutic and preventive vulnerabilities in these microbial pathogens;

2)rational screen and development of potential antivirals against their infections;

3)structure-guided engineering & functional reshaping of host factors for the treatment or prevention of these high-risk infectious diseases.

Expertise  

Integrative Structural Biology, Structural Proteomics 


Biography

2004 B.S.    National Talents Training Program, College of Life Sciences, Wuhan University

2010 Ph.D. of Biochemistry and Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science

2010-2013 Visiting Fellow, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S.

2013-2015 Postdoctoral Scholar, Department of Molecular and Cell Biology, University of California, Berkeley, U.S.

2015.11-2020.09 Co-PI, Research Associate Professor, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China

2020.09-present Principle investigator & Tenure-track assistant professor, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China


Selected Awards and Honors

2017  Young Scholar, Natural Science Foundation of China

2016  Pujiang Scholar, Science and Technology Commission of Shanghai Municipality

Selected Publications: (* co-first author, # correspondence author)      

  1. Wang LJ*, Xue W*, Zhang HX*, Gao RZ*, Qiu HY*, Wei J, Zhou LN, Lei YN, Wu XC, Li X, Liu CF, Wu J, Chen QB, Ma HH, Huang XX, Cai C, Zhang Y,Yang B#, Yin H#, Yang L#, Chen J#. (2021) Eliminating genome-wide and transcriptome-wide off-target mutations by base editor. Nature Cell Biology, DOI:10.1038/S41556-021-00671-4

  2. Shi X*, Wan Y*, Wang N*, Xiang J*, Wang T, Yang X, Wang J, Dong X, Dong L, Yan L, Li Y, Liu L, Hou S, Zhong Z, Wilson IA, Yang B, Yang G#, Lerner RA#.(2021) Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.Nature Communications, 12(1):2547

  3. Meng B, Lan KK, Xie J, Lerner RA, Wilson IA#, Yang B#. (2020) Inhibitory antibodies identify novel sites of therapeutic vulnerability in rhinovirus and other Enteroviruses. Proceedings of the National Academy of Sciences, 117 (24): 13499-13508

  4. Wang X*, Ding C*, Yu W*, Wang Y*, He S*, Yang B*, Xiong YC, Wei J, Li J, Liang J, Lu Z, Zhu W, Wu J, Zhou Z, Huang X, Liu Z#, Yang L#, Chen J#. (2020) Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response. Cell Report, 31(9):107723

  5. Cui YR*, Wang SJ*, Chen J, Li J, Chen W, Wang S, Meng B, Zhu W, Zhang Z, Yang B, Jiang B, Yang G, Ma P#., Liu J#. (2020) Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides. Genome Biology, 21(1):51

  6. Yang L#, Yang B#, Chen J#. (2019) One Prime for All Editing. Cell,179(7):1448-1450

  7. Xu JC*, Cui KJ*, Shen LQ, Shi J, Li LT, You LL, Fang CL, Zhao GP#, Feng Y#, Yang B#, Zhang Y#. (2019) Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor. eLife,8: e50928

  8. Zhao Q*, Ren C*, Liu L, Chen J, Shao Y, Sun N, Sun R, Kong Y, Ding X, Zhang X, Xu Y, Yang B, Yin Q#, Yang X#, Jiang B#. (2019) Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. Journal of Medicinal Chemistry, 62(20):9281-9298

  9. Wang Y*, Gao R*, Wu J, Xiong YC, Wei J, Zhang S, Yang B, Chen J#, Yang L#. (2019) Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs. Genome Biology, 20(1):218

  10. Xia S, Yan L, Xu W, Agrawal AS, Algaissi A, Tseng CK, Wang Q, Du L, Tan W, Wilson IA#, Jiang S#, Yang B#, Lu L#. (2019) A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Science Advances, 5(4): eaav4580

  11. Chen J#, Yang B#, Yang L#. (2019) To BE or not to BE, that is the question. Nature Biotechnology, 37(5):520-522

  12. Yang B#, Yang L# and Chen J#. (2019) Development and Application of Base Editors. TheCRISPR Journal, 2: 91-104

  13. Yan L, Meng B, Xiang J, Wilson IA# & Yang B#. (2018) Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86Å resolution. Acta Crystallographica Section D, 74(Pt 9):841-851

  14. Wang X*, Li J*, Wang Y*, Yang B*, Wei J, Wu J, Wang R, Huang X#, Chen J#, Yang L#. (2018) Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion. Nature Biotechnology, 36(10):946-949 

  15. Qiang M, Dong X, Zha Z, Zuo XK, Song XL, Zhao LX, Yuan C, Huang C, Tao PD, Hu Q, Li WG, Hu WH, Li J, Nie Y, Buratto D, Zonta F, Ma PX, Yu Z, Liu LL, Zhang Y, Yang B, Xie J, Xu TL, Qu ZH#, Yang G#, Lerner RA#. (2018) Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death. Proceedings of the National Academy of Sciences, 115(32): E7469-E7477

  16. Li X*, Wang Y*, Liu Y*, Yang B*, Wang X, Wei J, Lu Z, Zhang Y, Wu J, Huang X#, Yang L#, Chen J#. (2018) Base editing with a Cpf1-cytidine deaminase fusion. Nature Biotechnology, 36(4):324-327

  17. Lei L*, Chen H*, Xue W*, Yang B*, Hu B*, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Gao J, Sha J, Zhuang M, Huang X, Shen B#, Yang L#, Chen J#. (2018) APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks. Nature Structural & Molecular Biology, 25(1):45-52

  18. Wang L*, Xue W*, Yan L*, Li X, Wei J, Chen M, Wu J, Yang B#, Yang L#, Chen J#. (2017) Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor. Cell Research, 27(10):1289-1292

  19. Yang B#, Li X, Lei L, Chen J#. (2017) APOBEC: From mutator to editor. Journal of Genetics and Genomics, 44(9):423-437

  20. Yang B, Stjepanovic G, Shen Q, Martin A, Hurley JH#. (2015) Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation. Nature Structural & Molecular Biology, 22(6):492-8

  21. Hurley JH#, Yang B. (2014) Making sense of Vps4. The Journal of Molecular Biology, 426(3):503-6

  22. Yang B, Zhong C, Peng Y, Lai Z, Ding J#. (2010)Molecular mechanisms of off-on switch of activities of human IDH1 by tumor-associated mutation R132H. Cell Research, 20:1188-1200 (Cover story)

  23. Dong X*, Yang B*, Li Y, Zhong C, Ding J#. (2009) Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein. The Journal of Biological Chemistry, 284:23754-23764

  24. Dong X*, Zhou M*, Zhong C, Yang B, Shen N, Ding J#. (2009) Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase. Nucleic Acids Research, 38:1401-1412

  25. Shen N, Zhou M, Yang B, Yu Y, Dong X, Ding J#. (2008) Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states. Nucleic Acids Research, 36:1288-1299

  26. Shen N*, Guo L*, Yang B, Jin Y and Ding J#. (2006) Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity. Nucleic Acids Research, 34:3246-3258