课题组长（PI）、助理教授、研究员、博士生导师
所在学院: 免疫化学研究所、生命科学与技术学院
研究方向: 分子免疫学，肿瘤免疫学，免疫靶向治疗
联系方式: libin2@shanghaitech.edu.cn
教育经历：
2002.09-2006.07 佳木斯大学 本科
2009.09-2012.07 山东大学 硕士
2015.09-2022.11 蒙特利尔大学 博士
博士后经历：
2022.12-2026.06 Molecular Oncology Research Unit, Institut de recherches cliniques de Montréal 博士后
研究兴趣：
实验室致力于解析免疫系统的基本规律, 并将这些认识应用于开发新型肿瘤免疫疗法。目前已有原创免疫治疗靶点正在转化为 First-in-Class 抗肿瘤新药。主要研究内容:
1）T细胞新型免疫检查点的发现及相关药物研发；
2）调控T细胞耗竭的分子和细胞过程；
3）解析免疫相关疾病微环境，揭示免疫细胞在肿瘤免疫逃逸、动脉粥样硬化慢性炎症及组织损伤修复中的调控机制。
获得荣誉：
1. MCM Ph.D. Scholarship | 2016-2019
2. CSC Ph.D. Scholarship | 2015-2019
3. FESP Scholarship | 2015-2017
4. Bourse de recrutement de la Faculté de médecine | 2015
5. Excellent Graduation Thesis Award | 2006
专利：
Veillette, A.; Li, B.; Zhong, M. C.; Qian, J. (2025). Novel blocking anti-human SLAMF6 monoclonal antibodies as anti-cancer agents. US Patent
代表性论文:
1. Li, B.#, Zhong, M. C., Galindo, C. C., Dou, J., Qian, J., Tang, Z., Davidson, D., & Veillette, A. (2026). SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer. Nature, DOI: 10.1038/s41586-026-10106-5.
2. Zhu, K., Dou, J., Li, B., Qian, J., Zhong, M. C., Tang, Z., Lu, Y., & Veillette, A. (2025) CD2 and its ligands are involved in development and activation of MAIT cells. Journal of Experimental Medicine, 222(12), e20250431.
3. Li, R., Galindo, C. C., Davidson, D., Guo, H., Zhong, M. C., Qian, J., Li, B., Ruzsics, Z., Lau, C. M., O'Sullivan, T. E., Vidal, S. M., Sun, J. C., & Veillette, A. (2024) Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48. Cell Reports, 43(3), 113800.
4. Li, B.#, Lu, Y., Zhong, M. C., Qian, J., Li, R., Davidson, D., Tang, Z., Zhu, K., Argenty, J., de Peredo, A. G., Malissen, B., Roncagalli, R., & Veillette, A. (2022) Cis interactions between CD2 and its ligands on T cells are required for T cell activation. Science Immunology, 7(74), eabn6373.
5. Lee, J. S., Jeong, S. J., Kim, S., Chalifour, L., Yun, T. J., Miah, M. A., Li, B., Majdoubi, A., Sabourin, A., Keler, T., Guimond, J. V., Haddad, E., Choi, E. Y., Epelman, S., Choi, J. H., Thibodeau, J., Oh, G. T., & Cheong, C. (2018) Conventional Dendritic Cells Impair Recovery after Myocardial Infarction. Journal of Immunology, 201(6), 1784–1798.
6. Yun, T. J., Lee, J. S., Machmach, K., Shim, D., Choi, J., Wi, Y. J., Jang, H. S., Jung, I. H., Kim, K., Yoon, W. K., Miah, M. A., Li, B., Chang, J., Bego, M. G., Pham, T. N., Loschko, J., Fritz, J. H., Krug, A. B., Lee, S. P., Keler, T., … Cheong, C. (2016) Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Cell Metabolism, 23(5), 852–866.
