祝献民 博士

发布者:冯明静发布时间:2019-12-12浏览次数:1437


    祝献民  博士

 

副研究员

邮件: zhuxm@@shanghaitech.edu.cn

研究方向:

利用单细胞测序和大鼠模式动物平台,聚焦哺乳动物组织器官分化和发育的基因调控机制,以及糖尿病和肿瘤等重大疾病的转化医学研究。 育背景:

上海科技大学,免疫化学研究所,副研究员

同济大学,生科院,副研究员

NIH/NHLBI,博士后

Drexel University,生物学,博士

中科院上海生物工程研究中心,生化与分子生物学,硕士

华东师范大学,生物化学,学士

 代表著作:

Jing Zhang, Haiping Zhang, Lele Zhang, Dianke Li, Mengfan Qi, Liping Zhang, Huansha Yu, Di Wang, Gening Jiang, Xujun Wang*, Xianmin Zhu*, Peng Zhang*. Single-cell transcriptome identifies drug-resistance signature and immunosuppressive microenvironment in metastatic small cell lung cancer. Adv Genet. 2022, 3: 2100060. 


Youjin Hu, Kevin Huang, Qiao Zeng, Yun Feng, Qiong Ke, Qin An, Lian-Ju Qin, YuGui Cui, Ying Guo, Dicheng Zhao, Yu Peng, Di Tian, Kun Xia, Yong Chen, Bin Ni, Jinmei Wang, Xianmin Zhu, Lai Wei, Yizhi Liu, Peng Xiang, Jia-Yin Liu*, Zhigang Xue*, Guoping Fan*. Single-cell analysis of nonhuman primate preimplantation development in comparison to humans and mice. Dev Dyn. 2021, 250(7):974-985. 


Di He, Di Wang, Ping Lu, Nan Yang, Zhigang Xue, Xianmin Zhu*, Peng Zhang*, Guoping Fan*. Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations. Oncogene. 2021; 40(2):355-368.

 

Ping Lu, Guang Yang, Lichun Jiang, Wen He, Wanwan Wu, Lingbin Qi, Shijun Shen, Junhua Rao, Peng Zhang, Zhigang Xue, Cizhong Jiang, Guoping Fan*, Xianmin Zhu*. Characterizing disease progression of nonalcoholic steatohepatitis in Leptin deficient rats by integrated transcriptome analysis. Experimental Biology and Medicine. 2021; 246(6):678-687.

 

Di He, Junhui Zhang, Wanwan Wu, Ning Yi, Wen He, Ping Lu, Bin Li, Nan Yang, Di Wang, Zhigang Xue, Peng Zhang, Guoping Fan*Xianmin Zhu*. A novel immunodeficient rat model supports human lung cancer xenografts. FASEB J. 2019, 33(1):140-150.

 

Ganlu Hu, Kevin Huang, Youjin Hu, Guizhen Du, Zhigang Xue, Xianmin Zhu*, and Guoping Fan*.  Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons. Sci Rep. 2016, 6: 31851.

 

Shuyang Xu#, Xianmin Zhu#,Hong Li#, Youtian Hu, Jinping Zhou, Di He, Yun Feng, Lina Lu, Guizhen Du, Youjin Hu, Tiancheng Liu, Zhen Wang, Guohui Ding, Jiayu Chen, Shaorong Gao, Fang Wu, Zhigang Xue, Yixue Li, and Guoping Fan*. The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat. Sci Rep. 2016, 6: 28508.

 

Youjin Hu, Kevin Huang, Qin An, Guizhen Du, Ganlu Hu, Jinfeng Xue, Xianmin Zhu, Cun-Yu Wang, Zhigang Xue* and Guoping Fan*. Simultaneous profiling of transcriptome and DNA methylome from a single cell. Genome Biol. 2016, 5;17(1):88.

 

Stephen S. Gisselbrecht, Luis Barrera, Martin Porsch, Preston W. Estep, Anastasia Vedenko, Anton Aboukhalil, Alexandre Palagi, Yongsok Kim, Xianmin Zhu, Brian Busser, Caitlin E. Gamble, Antonina Iagovitina, Alan M. Michelson, Martha L. Bulyk*. Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos. Nature Methods. 2013, 10(8): 774-80.

 

Xianmin Zhu, Shaad M. Ahmad, Anton Aboukhalil, Brian W. Busser, Yongsok Kim, Terese R. Tansey, Adrian Haimovich, Neal Jeffries, Martha L. Bulyk and Alan M. Michelson*. Differential regulation of mesodermal gene expression by Drosophila cell type- specific Forkhead transcription factors. Development. 2012, 139(8): 1457-66.

 

Xianmin Zhu, Neetu Singh, Christopher Donnelly, Pamela Boimel and Felice Elefant*. The cloning and characterization of histone acetyltransferase human homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 is essential for multicellular development. Genetics. 2007, 175(3): 1229-40.

 科研项目:

1. 上海市科学技术委员会, “科技创新行动计划”实验动物研究领域,22140900100,新型免疫系统人源化大鼠模型的建立和鉴定,2022-03  2025-03,90万元,在研,主持。

2. 国家自然科学基金委员会,面上项目,81570521,基于瘦素基因敲除大鼠模型的非酒精性脂肪肝的致病机制研究和实验性治疗,2016-012019-1257万元,结题,主持。

3. 科技部,国家重点基础研究发展计划(973计划),2015CB964702,全基因组解析干细胞肝系分化的调控网络、移植后种子细胞与宿主内环境的相互作用、及修复肝损伤的分子机制,2015-012019-12165万元,结题,参与。

4. 科技部,国家重点基础研究发展计划(973计划),2015CB964602,组织内环境对眼上皮成体干细胞增殖分化的影响及机理,2015-012019-12105万元,结题,参与。

5. 国家自然科学基金委员会,重点项目,81430026X染色体失活与异常胚胎发育相关性的分子机制研究,2015-012019-12320万元,结题,参与。

6. 上海科委,“科技创新行动计划”实验动物研究领域项目,15140903900,基于瘦素基因敲除的非酒精性脂肪肝大鼠模型的开发和实验性治疗,2015-072017-0925万元,结题,主持。

7. 教育部,“留学回国人员科研启动基金”,脆性X染色体综合征关键致病蛋白FMRP在神经细胞中转录调控机制的研究,20143.5万元,结题,主持。