储佑君 博士

发布者:冯明静发布时间:2019-12-23浏览次数:161

  Youjun Chu, Ph.D.

Engineer

Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University

Email:chuyj@@shanghaitech.edu.cn


Education

2007.9-2013.7              University of Science & Technology of China, Ph.D. in Cell Biology

2011.11-2012.12           Morehouse School of Medicine (U.S.A.), Joint Ph.D. student with China Scholarship Council scholarship

2003.9-2007.7             Heilongjiang University, Bachelor in Biotechnology

EMPLOYMENTS

2015.11-Now               Shanghai Institute for Advanced Immunochemical Studies (ShanghaiTech University)       

2013.9- 2015.9              State Key Laboratory of Molecular Biology (Chinese Academy of Sciences)   Postdoctoral Research Fellow in Biochemistry & Molecular Biology

2007.5-2013.7               Anhui Key Laboratory of Cellular Dynamics & Chemical Biology (USTC) 

2011.11-2012.12           Confocal & Fluorescent Imaging Core (MSM)        

Publications:

1.  Chu Y, Yao PY, Wang W, Wang D, Wang Z, Zhang L, Huang Y, Ke Y, Ding X, Yao X. Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J Mol Cell Biol 3, 260-7 (2011).

2.  Zhao L, Jin C, Chu Y, Varghese C, Hua S, Yan F, Miao Y, Liu J, Mann D, Ding X, Zhang J, Wang Z, Dou Z, Yao X. Dimerization of CPAP orchestrates centrosome cohesion plasticity. J Biol Chem 285, 2488-97 (2010).

3.  Zhang L, Shao H, Huang Y, Yan F, Chu Y, Hou H, Zhu M, Fu C, Aikhionbare F, Fang G, Ding X, Yao X. PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity. J Biol Chem 286, 3033-46 (2011).

4.  Chu L, Zhu T, Liu X, Yu R, Bacanamwo M, Dou Z, Chu Y, Zou H, Gibbons GH, Wang D, Ding X, Yao X.. SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis. J Mol Cell Biol 4, 331-40 (2012).

5.  Wang X, Zhuang X, Cao D, Chu Y, Yao P, Liu W, Liu L, Adams G, Fang G, Dou Z, Ding X, Huang Y, Wang D, Yao X. Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules. J Biol Chem 287, 39380-90 (2012).

6. Ward T, Wang M, Liu X, Wang Z, Xia P, Chu Y, Wang X, Liu L, Jiang K, Yu H, Yan M, Wang J, Hill DL, Huang Y, Zhu T, Yao X. Regulation of a dynamic interaction between two microtubule-binding proteins, EB1 and TIP150, by the mitotic factor PCAF orchestrates kinetochore microtubule plasticity and chromosome stability during mitosis. J Biol Chem 288, 15771-85 (2013).

7. Miao H, Jia Y, Xie S, Wang X, Zhao J, Chu Y, Zhou Z, Shi Z, Song X, Li L. Domain of caprin-2 in canonical wnt signaling. J Biol Chem 289, 34104-34113 (2014).

8. Shao H, Huang Y, Zhang L, Yuan K, Chu Y, Dou Z, Jin C, Garcia-Barrio M, Liu X, Yao X. Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore biorientation and faithful chromosome segregation. Sci Rep 5:12204 (2015).

9. Duan H, Wang C, Wang M, Gao X, Yan M, Akram S, Peng W, Zou H, Wang D, Zhou J, Chu Y, Dou Z, Barrett G, Green HN, Wang F, Tian R, He P, Wang W, Liu X, Yao X. Phosphorylation of PP1 regulator Sds22 by PLK1 ensures accurate chromosome segregation. J Biol Chem 291(40), 21123-36 (2016).

10. Xu L, Carrer A, Zonta F, Qu Z, Ma P, Li S, Ceriani F, Buratto D, Crispino G, Zorzi V, Ziraldo G, Bruno F, Nardin C, Peres C, Mazzarda F, Salvatore AM, Raspa M, Scavizzi F, Chu Y, Xie S, Yang X, Liao J, Liu X, Wang W, Wang S, Yang G, Lerner RA, Mammano F. Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders. Front Mol Neurosci. Sep 22;10:298(2017).