Research Associate Professor, Co-Principal Investigator
Laboratory: Cancer Stem Cell Lab
Research Interest: Molecular mechanisms of glioblastoma and druggable target identification Email: wuyh2@@shanghaitech.edu.cn
Biography
2020.4-present, Research associate professor,
Shanghai Institute for Advanced Immunochemical studies (SIAIS), ShanghaiTech University
2015. 01-2020.03, Postdoc
Supervisor: Prof. Peter Lichter
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
2011. 10-2014. 12, Postdoc
Supervisor: Prof. Günter Stalla
Research group of clinical neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany 2005-2011, Ph.D. Max Planck Institute of Psychiatry and Munich University, Munich, Germany
2002-2005, M.S.
Chinese Academy of Medical Sciences and Peking Union Medical College (PUMC), Beijing, China
March-June 2002, director office staff
Beijing Genomics Institute, Beijing, China
1997-2001, B.S.
Minzu University of China, Beijing, China
Selected Publications 1. Peng T*, Ma X*, Hua W*, Wang C, Chu Y, Sun M, Fermi V, Hamelmann S, Lindner K, Shao C, Zaman J, Tian W, Zhuo Y, Harim Y, Stöffler N, Hammann L, Xiao Q, Jin X, Warta R, Lotsch C, Zhuang X, Feng Y, Fu M, Zhang X, Zhang J, Xu H, Qiu F, Xie L, Zhang Y, Zhu W, Du Z, Salgueiro L, Schneider M, Eichhorn F, Lefevre A, Pusch S, Grinevich V, Ratliff M, Loges S, Bunse L, Sahm F, Xiang Y, Unterberg A, von Deimling A, Platten M, Herold-Mende C, Wu Y#, Liu HK#, Mao Y#. Individualized patient tumor organoids fully recapitulate human brain tumor ecosystems and predict patient response to therapy. Cell Stem Cell. 2025 Feb. 11. Co-Correspondence authorship
2.Xue J*, Chu Y*, Huang Y*, Chen M, Sun M, Fan Z, Wu Y#, Chen L#. A tumorigenicity evaluation platform for cell therapies based on brain organoids. Translational Neurodegeneration. 2024 October 26. Co-Correspondence authorship 3.Man KH*, Wu Y*, Gao Z, Spreng AS, Keding J, Mangei J, Boskovic P, Mallm JP, Liu HK, Imbusch CD, Lichter P, Radlwimmer B. SOX10 mediates glioblastoma cell-state plasticity. EMBO Rep. 2024 Sep. 16 joint first authorship 4. Costa AL, Doncevic D, Wu Y, Yang L, Man KH, Spreng AS, Winter H, Fletcher MNC, Radlwimmer B, Herrmann C. A new IDH-independent hypermethylation phenotype is associated with astrocyte-like cell state in glioblastoma. Genome Biol. 2025 Jul 3;26(1):192. 5.Fu M*, Zhao J*, Zhang L, Sheng Z, Li X, Qiu F, Feng Y, You M, Xu H, Zhang J, Zeng R, Huang Y, Li C, Chen W, Chen Z, Peng H, Li L, Wu Y, Ye D, Chi Y#, Hua W#, Mao Y#. Overcoming tyrosine kinase inhibitor resistance in lung cancer brain metastasis with CTLA4 blockade. Cancer Cell.2024 Nov 11;42(11):1882-1897.e7. 6. Fu M*, Zhang M*, Zhang L, Feng Y, Gao C, Xu H, Zhang J, Zhang H, Peng T, Chu Y, Wu Y, Wang P, Ye D#, Mao Y#, Hua W#. Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation. Cell Rep. 2025 Jan 28;44(1):115142.
7. Wang C*, Sun M*, Shao C, Schlicker L, Zhuo Y, Harim Y, Peng T, Tian W, Stöffler N, Schneider M, Helm D, Chu Y, Fu B, Jin X, Mallm JP, Mall M, Wu Y, Schulze A, Liu HK. A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs. NPJ Precis Oncol. 2024 Jan 26;8(1):19. 8. Zhang J, Feng Y, Li G, Zhang J, Zhang X, Zhang Y, Qin Z, Zhuang D, Qiu T, Shi Z, Zhu W, Zhang R, Wu Y, Liu H, Cao D, Hua W, Mao Y. Distinct aneuploid evolution of astrocytoma and glioblastoma during recurrence. NPJ Precis Oncol. 2023 Sep 23;7(1):97. 9. Zhang J, Fu M, Wu J, Fan F, Zhang X, Li C, Yang H, Wu Y#, Yin Y#, Hua W#. The Anti-Glioma Effect of Juglone Derivatives through ROS Generation. Front Pharmacol. 2022 Jun 14;13:911760. Co-Correspondence authorship 10.Wu Y*, Fletcher M*, Gu Z*, Wang Q, Costa B, Bertoni A, Man KH, Schlotter M, Felsberg J, Mangei J, Barbus M, Gaupel AC, Wang W, Weiss T, Eils R, Weller M, Liu H, Reifenberger G, Korshunov A, Angel P, Lichter P, Herrmann C#, Radlwimmer B#. Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype. Nature Communications. 2020 Dec 18;11(1):6434. joint first authorship 11. Lucia K, Wu Y, Garcia JM, Barlier A, Buchfelder M, Saeger W, Renner U, Stalla GK, Theodoropoulou M. Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription. Oncogene. 2020 Apr;39(16):3367-3380. 12. Körber V, Yang J, Barah P, Wu Y, et al. Evolutionary trajectories of IDH-wild-type glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis. Cancer Cell. 2019 Apr 15;35(4):692-704.e12. 13. Rusu P, Shao C, Neuerburg A, Acikgöz AA, Wu Y, et al. GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile. Cell Stem Cell. 2019 Aug 1;25(2):241-257.e8. 14. Wu Y*, Patchev AV, Daniel G, Almeida OFX, Spengler D，Early Life stress reduces DNA methylation of the Pomc gene in male mice. Endocrinology. 2014 155 (5), 1751-1762 * Corresponding author 15. Wu Y, Tedesco L, Lucia K, Schlitter AM, Garcia JM, Esposito I, Auernhammer CJ, Theodoropoulou M, Arzt E, Renner U, Stalla GK. RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors. Oncotarget. 2016, 7 (36), 57878-57893 16. Wu Y, Utpadel D, Lange M, Kuhlen Stalla GK, Renner U. Regulation of vascular endothelial growth factor A (VEGF-A ) secretion in human meningiomas in vitro. J Neurooncol. 2014, 119 (2), 263-273 17. Curic S#, Wu Y#, Shan B, Schaaf C, Utpadel D, Lange M, Kuhlen D, Perone MJ, Arzt E, Stalla GK, Renner U. Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas. J Neurooncol. 2013 Jul;113 (3):385-96, # Co-first authors 18. Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmühl Y, Fischer D, Holsboer F, Wotjak CT, Almeida OF, Spengler D. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 2009 Dec; 12(12):1559-66. (cited 1050 times in Google Scholar) 19. Silva LS, Poschet G, Nonnenmacher Y, Becker HM, Sapcariu S, Gaupel AC, Schlotter M, Wu Y, Kneisel N, Seiffert M, Hell R, Hiller K, Lichter P, Radlwimmer B. Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype. EMBO Rep. 2017 Dec;18(12):2172-2185 20. Huang Z, Jones DTW, Wu Y, Lichter P, Zapatka M. confFuse: High-Confidence Fusion Gene Detection across Tumor Entities. Front Genet. 2017 Sep 29; 8:137. 21. Thewes V, Simon R, Hlevnjak M, Schlotter M, Schroeter P, Schmidt K, Wu Y, et al. The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer. Oncogene. 2017 Jul 20; 36(29):4124-4134. 22. Gerez J, Tedesco L, Bonfiglio JJ, Fuertes M, Barontini M, Silberstein S, Wu Y, et al. RSUME inhibits VHL and regulates its tumor suppressor function. Oncogene. 2015 Sep 10; 34(37):4855-66. 23. Murgatroyd C, Wu Y, Bockmühl Y, Spengler D. The Janus face of DNA methylation in aging. Aging (Albany NY). 2010 Mar 20; 2(2):107-10. 24. Murgatroyd C, Wu Y, Bockmühl Y, Spengler D. Genes learn from stress: How infantile trauma programs us for depression. Epigenetics. 2010 Apr 31; 5(3). (cited 121 times in Google Scholar) 25. Li D, Wu Y, Min D, Wang Z, Zheng J, Sun D, Ma X. The clinical value of denaturing high performance liquid chromatography in detecting mutations of breast cancer susceptibility gene-1, Chinese Journal of Laboratory Medicine. 2006, 29 (7) 26. Wu Y, Wang G, Wu E, Ma X. Recombinant and Identification of Macrophage Inhibitory Cytokine 1 in Pichia Yeast. Chinese Journal of Family Planning. 2005, 13 (7): 409-13
Independent journal reviewer: International Journal of Cancer, Journal of Alzheimer's Diseases, Frontiers in Molecular Neurosciences, Frontiers in Behaviour Neurosciences, Scientific Reports, Plos One
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