大分子药物递呈实验室助理研究员
邮箱：meihong@shanghaitech.edu.cn
地址：上海科技大学人字楼C101
科研兴趣
CRISPR基因组筛选
教育及科研经历
2022-至今，助理研究员，上海科技大学-免疫化学研究所
2017-2022，上海科技大学，免疫化学研究所，博士后
2011-2017，生物化学与分子生物学博士，中国科学院上海生命科学研究院
2007-20011，生物科学理学学士，湖南科技大学生命科学学院
发表论文（#, 共同第一作者; *, 通讯作者）
8. Gao J#, Mei H#, Sun J#, Li H#, Huang Y, Tang Y, Duan L, Liu D, Pang Y, Wang Q, Gao Y, Song K, Zhao J*, Zhang C*, Liu J* (2022) Neuropilin-1-mediated SARS-CoV-2 infection in bone marrow-derived macrophages inhibits osteoclast differentiation. Adv Biol, 2200007.
7. Mei H#, Zha Z#, Wang W#, Xie Y, Huang Y, Li W, Wei D, Zhang X, Qu J*, Liu J* (2021) Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist. Genome Biol 22, 297.
6. Wang Y#, Liu D#, Lin H#, Chen D, Sun J, Xie Y, Wang X, Ma P, Nie Y, Mei H, Zhao B, Huang X, Jiang X*, Qu J*, Liu J* (2021) Development of a broadly applicable Cas12a-linked beam unlocking reaction for sensitive and specific detection of respiratory pathogens including SARS-CoV-2. ACS Chem Biol 16, 491-500.
5. Ma P#, Meng Q#, Sun B, Zhao B, Dang L, Zhong M, Liu S, Xu H, Mei H, Liu J, Chi T, Yang G, Liu M*, Huang X*, Wang X*. (2020) MeCas12a, a highly sensitive and specific system for COVID-19 detection. Adv Sci 7, 2001300.
4. Yao PL, Zhuo S, Mei H, Chen XF, Li N, Zhu TF, Chen ST, Wang JM, Hou RX, Le YY*. Androgen alleviates neurotoxicity of β-amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ, CNS Neuroscience & Therapeutics, 2017, 23(11): 855-865.
3. Mei H, Yao PL, Wang SS, Li N, Zhu T, Chen X, Yang M, Zhuo S, Chen ST, Wang JM, Wang H, Le YY*. Chronic low-dose cadmium exposure impairs cutaneous wound healing through inhibiting early inflammatory responses after skin injury., Toxicological Science, 2017, 159(2): 327-338.
3. Zhuo S, Yang M, Zhao Y, Chen XF, Zhang F, Li Na, Yao PL, Zhu TF, Mei H, Wang S, Li S, Chen ST, Le YY*. MicroRNA-451 Negatively regulates hepatic glucose production and glucose homeostasis by targeting glycerol kinase-mediated gluconeogenesis, Diabetes, 2016, 65(11): 3276-3288.
1. Chen XF, Zhuo S, Zhu TF, Yao PL, Yang MM, Mei H, Li N, Wang JM, Chen ST, Richard D Ye, Li Y, Le YY*. Fpr2 Deficiency alleviates diet-induced Insulin resistance through reducing body weight gain and inhibiting inflammation mediated by macrophage chemotaxis and M1 polarization, Diabetes, 2019.6, 68(6): 1130-1142.
获资助项目
1. 中国博士后基金面上项目，2017M621551，《用CRISPR/Cas9筛选寨卡病毒受体》，2018.03-2019.06，5万，结题，负责人。
荣誉与奖项
2021，上海科技大学，优秀员工
2020，上海科技大学，优秀员工
2020，上海科技大学，COVID-19抗疫优秀员工
