副教授
邮箱：zhzhang0608@＠163.com
科研兴趣
分子毒理
教育及科研经历
2018-2019，访问教授，上海科技大学免疫化学研究所，大分子药物递呈实验室
2014-2018，博士后研究员，美国食品药品监督管理局，国家毒理学研究中心
2013-2014，博士后研究员，美国加州大学圣地亚哥分校
2013，生物化学与分子生物学博士，南开大学医学院
2010，免疫学硕士，南开大学医学院
2007，生物技术学士，河北经贸大学生物科学与工程学院
发表论文（*，通讯作者；#，共同第一作者）
27.Zhang Z, Ren Z, Chen S, Guo X, Liu F, Guo L, Mei N*. ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells. Archives of Toxicology 92(2):717-728.
26.Zhang Z, Yin J, Yang J, Shen W, Zhang C, Mou W, Luo J, Yan H, Sun P, Luo Y, Tian Y*, Xiang R*. miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/β-catenin signaling pathway. Oncotarget 7(46):75038-75051.
25.Zhang Z#, Chen S#, Mei H, Xuan J, Guo X, Couch L, Dobrovolsky VN, Guo L, Mei N*. Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Scientific Reports 5:14633.
24.Zhang Z, Yin J, Zhang C, Liang N, Bai N, Chang A, Liu Y, Li Z, Tan X, Li N, Lv D, Xiang R, Tian Y*, Liu C*. Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma. Cancer Biology & Therapy 13(6):435-442.
23.Zhang Z#, Chen Q#, Townsend TA, Mao C, You C, Yang W, Sun Z, Yu J, Yan H*. Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy. Molecular Medicine Reports 15(2):573-580.
22.Zhang Z, Li H, Manjanatha MG, Chen T, Mei N*. Neonatal exposure of 17β-estradiol has no effects on mutagenicity of 7,12-dimethylbenz [a] anthracene in reproductive tissues of adult mice. Genes and Environment 37:16.
21.Chen S#, Zhang Z#, Wu Y, Shi Q, Yan H, Mei N, Tolleson WH, Guo L*. Endoplasmic reticulum stress and store-operated calcium entry contribute to usnic acid-induced toxicity in hepatic cells. Toxicological Sciences 146(1):116-26.
20.Zhang Y#, Zhang Z#, Yan H*. Simvastatin inhibits ischemia/reperfusion injury-induced apoptosis of retinal cells via downregulation of the tumor necrosis factor-α/nuclear factor-κB pathway. International Journal of Molecular Medicine 36(2):399-405.
19.Zheng H#, Zhang Z#, Luo N, Liu Y, Chen Q, Yan H*. Increased Th17 cells and IL-17 in rats with traumatic optic neuropathy. Molecular Medicine Reports 10(4):1954-8.
18.Chen S, Zhang Z, Qing T, Ren Z, Yu D, Couch L, Ning B, Mei N, Shi L, Tolleson WH, Guo L*. Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells. Archives of Toxicology 91(3):1293-1307.
17.Yang J, Zhang Z, Chen C, Liu Y, Si Q, Chuang TH, Li N, Gomez-Cabrero A, Reisfeld RA, Xiang R, Luo Y*. MicroRNA -19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene. Oncogene 33(23):3014-23.
16.Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF 2nd, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson DA, Kipps TJ*. Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy. Proceedings of the National Academy of Sciences of the United States of America 111(48):7266-71.
15.Fang S, Meng X, Zhang Z, Wang Y, Liu Y, You C, Yan H*. Vorinostat modulates the imbalance of T cell subsets, suppresses macrophage activity, and ameliorates experimental autoimmune uveoretinitis. Neuromolecular Medicine 18(1):134–145.
14.Jiang F, Chen Q, Huang L, Wang Y, Zhang Z, Meng X, Liu Y, Mao C, Zheng F, Zhang J, Yan H*. TNFSF15 inhibits blood retinal barrier breakdown induced by diabetes. International Journal of Molecular Sciences 17(5): 615.
13.Meng X, Fang S, Zhang Z, Wang Y, You C, Zhang J, Yan H*. Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1–20 in mice. Cellular & Molecular Immunology 14(8):702-711.
12.Wang Y, Fan L, Meng X, Jiang F, Chen Q, Zhang Z, Yan H*. Transplantation of IL-10-transfected endothelial progenitor cells improves retinal vascular repair via suppressing inflammation in diabetic rats. Graefe's Archive for Clinical and Experimental Ophthalmology 254(10):1957-1965.
11.Liu Y, You C, Zhang Z, Zhang J, Yan H*. Roles of Treg/Th17 cell imbalance and neuronal damage in the visual dysfunction observed in experimental autoimmune optic neuritis chronologically. Neuromolecular Medicine 17(4):391-403.
10.Guo X, Chen S, Zhang Z, Dobrovolsky VN, Dial SL, Guo L, Mei N*. Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells. Chemico-Biological Interactions 235:27-36.
9.Wang Y, Chen Q, Zhang Z, Jiang F, Meng X, Yan H*. Interleukin-10 overexpression improves the function of endothelial progenitor cells stimulated with TNF-α through the activation of the STAT3 signaling pathway. International Journal of Molecular Medicine 35(2):471-7.
8.Chen S, Dobrovolsky VN, Liu F, Wu Y, Zhang Z, Mei N*, The role of autophagy in usnic acid-induced toxicity in hepatic cells. Toxicological Sciences 142(1):33-44.
7.Wang Y, Yuan Z, You C, Han J, Li H, Zhang Z, Yan H*. Overexpression p21WAF1/CIP1 in suppressing retinal pigment epithelial cells and progression of proliferative vitreoretinopathy via inhibition CDK2 and cyclin E. BMC Ophthalmology 14(1):144
6.Wang J, Chen S, Jiang F, You C, Mao C, Yu J, Han J, Zhang Z, Yan H*. Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomy. PLoS One 9(10):e110531.
5.Luo J, Zhao Q, Zhang W, Zhang Z, Gao J, Zhang C, Li Y, Tian Y*. A new panel of miRNAs provides a sensitive and specific tool for the diagnosis of breast cancer. Molecular Medicine Reports 10(2):785-9.
4.Bai N, Zhang C, Liang N, Zhang Z, Chang A, Yin J, Li Z, Luo N, Tan X, Luo N, Luo Y, Xiang R, Li X, Reisfeld RA, Stupack D, Lv D, Liu C*. Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53. Cancer Biology & Therapy 14(6):511-20.
3.Zhang Z and Tian Y*. Lymphocyte cytosolic protein 1 promotes the proliferation of diffuse large B-cell lymphoma cells. Academic Journal of Chinese PLA Medical School 34(10):1052-54.
2.Zhang C, Bai N, Chang A, Zhang Z, Yin J, Shen W, Tian Y, Xiang R, Liu C*. ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocyte. Cellular & Molecular Immunology 10(1):84-94.
1.Zhang C, Bai N, Zhang Z, Liang N, Dong L, Xiang R, Liu C*. TLR2 signaling subpathways regulate TLR9 signaling for the effective induction of IL-12 upon stimulation by heat-killed Brucella abortus. Cellular & Molecular Immunology 9(4):324-33.
专利
2.田亚平，张竹红。一种抑制原发性肝癌转移的新方法。专利号：ZL201210222212.5。
1.田亚平，张竹红。MiR-885-5p在制备判断原发性肝癌临床分期的诊断试剂中的用途。专利号：ZL201210222211.0。
获资助项目
1.国家自然科学基金青年基金项目，IL-10修饰的骨髓来源的神经干细胞对视网膜缺血再灌注损伤的作用及机制研究，81500743，21.6万，2016.01-2018.12，负责人。
