Research Assistant Professor
Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
Email:xuyw@@shanghaitech.edu.cn
Laboratory:Lab of Antibody Structure
Research Interest:
Structural studies of the immune system using integrative structural biology techniques, including x-ray crystallography, electron microscopy, and et.al.
Biography:
2007.07B.S., School of Life Science and Technology, Soochow University, Suzhou, Jiangsu Province, P. R. China
2011.07M.S., Institutes of Biomedical Sciences (IBS) / Department of Chemistry, Fudan University, Shanghai, P. R. China
2017.01Ph.D., Genecenter, Department of biochemistry, Faculty for Chemistry and Pharmacy, Ludwig-Maximilian University of Munich (LMU), Munich, Germany (2014.07-2017.01, Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry (MPIbpc), Goettingen, Germany)
2017.02-2017.06Postdoctoral Fellow, Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry (MPIbpc), Goettingen, Germany
2017.11-presentResearch Assistant Professor, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China
Selected Publications: (* co-first author)
1.Xu, Y., Bernecky, C., Lee, C.T., Maier, K.C., Schwalb, B., Tegunov, D., Plitzko, J.M., Urlaub, H. & Cramer, P. Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex.Nat Commun8, 15741 (2017).
2. Zhang, Y., Yang, H., Guo, X., Rong, N., Song, Y.,Xu, Y., Lan, W., Zhang, X., Liu, M., Xu, Y. & Cao, C. The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.Protein Cell5, 837-50 (2014).
3. Fang, R., Chen, F., Dong, Z., Hu, D., Barbera, A.J., Clark, E.A., Fang, J., Yang, Y., Mei, P., Rutenberg, M., Li, Z., Zhang, Y.,Xu, Y., Yang, H., Wang, P., Simon, M.D., Zhou, Q., Li, J., Marynick, M.P., Li, X., Lu, H., Kaiser, U.B., Kingston, R.E., Xu, Y. & Shi, Y.G. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation.Mol Cell49, 558-70 (2013).
4. Guo, X.*,Xu, Y.*, Wang, P., Li, Z., Xu, Y. & Yang, H. Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B.Acta Crystallogr Sect F Struct Biol Cryst Commun67, 907-10 (2011). *Co-first author
5. Yang, H., Wang, P., Dong, Z., Li, X., Gong, R., Yang, Y., Li, Z.,Xu, Y.& Xu, Y. Crystallization and preliminary crystallographic analysis of nosiheptide- resistance methyltransferase from Streptomyces actuosus in complex with SAM.Acta Crystallogr Sect F Struct Biol Cryst Commun66, 579-82 (2010).
