Postdoctoral research fellow
Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
Email: hanyb@@shanghaitech.edu.cn
Laboratory:Lab of Antibody Structure
Research Interest:
1) Structure elucidation of gut microbiome metabolic enzyme related with human disease, and developing new microbial-enzyme-targeted inhibitor.
2) Structure determination of immune-related protein, and protein engineering of novel therapeutic antibodies using structure-based approach (rational design) and/or directed evolution.
Biography:
2007 B.S. of Biological science, School of Life Sciences, YanTai University, Yantai, China
2010 M.S. of Microbiology, School of Bioengineering, East China University of Science and Technology, Shanghai, China
2016 Ph.D. of Biology, School of Life sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
2016-present Postdoctoral research fellow, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China
Representative Publications:
1.Yun-Bin Han, Liu-Qing Chen, Zhuo Li, Yu-Meng, Tan, Yan Feng and Guang-Yu Yang. Chen LQ, Li Z, Tan YM, Feng Y, Yang GY. Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase. J Biol Chem. 2017 Feb 8. [Epub ahead of print]
2.Fu-QiangMa, Michael Fischer, Yun-Bin Han, Stephen G. Withers, Yan Feng, Guang-Yu Yang.Substrate Engineering Enabling Fluorescence Droplet Entrapment for IVC-FACS-Based Ultrahigh-Throughput Screening.Analytical Chemistry. 2016,88(17):8587-95.
3. Feng-Tao Huang, Yun-Bin Han, Yan Feng, Guang-Yu Yang. A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production. Journal of Lipid Research. 2015, 56(9):1836-1842
4. Yun-Bin Han, Lie Wu, Jamie R. Rich, Feng-Tao Huang, Stephen G. Withers, Yan Feng, Guang-Yu Yang. Comprehensive characterization of sphingolipid ceramide N-deacylase for the synthesis and fatty acid remodeling of glycosphingolipids. Appl Microbiol Biotechnol. 2015, 99(16):6715-6726
5. Yun-Bin Han, Chen Huang, Yan Feng. Design of the enzymes and assembly of the novel synthetic pathways. Chinese Bulletin of Life Sciences. 2011, 23(09):869-874 (in Chinese)
6. Yun-Bin Han, Wen-Yu Zhou, Yuan Hu, Dong-Zhi Wei, Ya-Ling Shen, Shan-Zong Fang, Xiong-Xiong Jin, Feng-Qi Ye. Screening and identification of CAH-producing strain, enzyme properties of cephalosporin-C deacetylase and optimization of enzyme production. Industrial Microbiology. 2011, 41(2):1-6 (in chinese)
