Haikun Liu Ph.D.

发布者:冯明静发布时间:2019-11-15浏览次数:34

  Haikun Liu Ph.D.

Distinguished Adjunct Professor

Principal Investigator

Lab of Cancer Stem Cell

Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University

Email: liuhk1@shanghaitech.edu.cn


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Biography                       

2019~   Adjunct professor, SIAIS, ShanghaiTech

2015~    Head of Division of Molecular Neurogenetics, DKFZ

2011~2015   Head of Helmholtz University Young Investigator Group-Normal and neoplastic CNS stem cells, German Cancer Research Center (DKFZ), DKFZ-ZMBH alliance, D-69120, Heidelberg, Germany.

2005~2010   Postdoc with Prof. Günther. Schütz in the Dept. Molecular Biology of the Cell I, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.

2000~2005   Ph.D student, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032. P.R.China. Ph.D granted on 30. July. 2005.

1996~2000   Shangdong Normal University.

 

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Selected Publications

  1. Rusu,P.,  Shao, C., Neuerburg, A., Acikgöz, A.A., Wu, Y., Zou, P., Phapale, P., Shankar, TS., Döring, K., Dettling, S., Körkel-Qu, H., Bekki, G., Costa, B., Guo, T., Friesen, O., Schlotter, M., Heikenwalder, M., Tschaharganeh, DF.,  Bukan, B., Kramer, G., Angel, P., Herold-Mende, C., Radlwimmer, B., Liu, H-K. (2019) GPD1 specifically marks dormant glioma stem cells with a distinct metabolic profile. Cell Stem Cell

  2. Venkataramani V, Tanev DI, Strahle C, Studier-Fischer A, Fankhauser L, Kessler T, Körber C, Kardorff M, Ratliff M, Xie R, Horstmann H, Messer M, Paik SP, Knabbe J, Sahm F, Kurz FT, Acikgöz AA, Herrmannsdörfer F, Agarwal A, Bergles DE, Chalmers A, Miletic H, Turcan S, Mawrin C, Hänggi D, Liu H-K, Wick W, Winkler F, Kuner T. (2019) Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature, 2019 Sep 18. doi: 10.1038/s41586-019-1564-x.

  3. Duman, C., Yaqubi, K., Hoffmann, A., Acikgöz, A.A., Korshunov, A., Bendszus, M., Herold-Mende, C., Liu, H.-K., and Alfonso, J. (2019). Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation. Cell Metabolism.https://doi.org/10.1016/j.cmet.2019.04.004

  4. Feng, W., Kawauchi, D., Koekel-Qu, H., Deng, H., Serger, E., Sieber, L., Lieberman, JA., Jimeno-Gonzalez, S., Lambo, S., Hanna, B., Harim, Y., Jansen, M., Neuerburg, A., Friesen, O., Zuckermann, M., Rajendran,V., Gronych, J., Ayrault, O., Korshunov, A., Jones, D., Kool, M., Northcott, P., Lichter, P., Cortes-Ledesma, F., Pfister, SM., Liu H-K. (2017) The chromatin remodeler Chd7 is indispensable for mamalian brain development through activation of a neuronal differentiation program. Nature Communications.14758 (2017)

  5. Feng, W., Liu, H-K. (2017) Revealing the hidden powers that fuel adult neurogenesis. Cell Stem Cell. 20 (2), 154-156

  6. Osswald, M., Jung, E., Sahm, F., Solecki, G., Venkataramani, V., Blaes, J., Weil, S., Horstmann, H., Wiestler, B., Syed, M., Huang, L., Ratliff, M., Karimian Jazi, K., Kurz, F. T., Schmenger, T., Lemke, D., Gommel, M., Pauli, M., Liao, Y., Haring, P., Pusch, S., Herl, V., Steinhauser, C., Krunic, D., Jarahian, M., Miletic, H., Berghoff, A. S., Griesbeck, O., Kalamakis, G., Garaschuk, O., Preusser, M., Weiss, S., Liu, H-K., Heiland, S., Platten, M., Huber, P. E., Kuner, T., von Deimling, A., Wick, W. and Winkler, F. (2015) Brain tumour cells interconnect to a functional and resistant network. Nature, 528, 93–98

  7. Zhu, Z., Kahn, A., Weiler, M., Blaes. J, Jestaedt L., Geibert M., Zou P., Gronych J., Bernhardt, O., Korshunov, A., Bugner, V., Lichter, P., Radlwimmer, B., Heiland S., Bendszus, M., Wick, W., Liu, H-K*. (2014) Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival. Cell Stem Cell,15, 185-198 

  8. Feng, W., Kahn, A., Bellvis P., Zhu, Z., Bernhardt, O., Herold-Mende, C., Liu, H-K. (2013). The chromatin remodeler CHD7 regulates adult neurogenesis via activation of  SoxC transcription factors.  Cell Stem Cell, 13, 62–72