Assistant Professor Principal Investigator Institute Shanghai Institute for Advanced Immunochemical Studies School of Life Science and Technology
Research Area
Microbial bioenergetics; Mitochondria in immunity; Structure Biology
Contact Info. wangq@shanghaitech.edu.cn
------------------------------------------------------------------------------------------------------------------ Biography
Dr. Wang received his BS degree (2005) and Ph.D. degree (2009) from Nankai University. He was a Research Assistant Professor in Institute of Biophysics, Chinese Academy of Sciences in Beijing from 2014-2018, and an Academic Visitor in the Division of Structural Biology in Nuffield Department of Clinical Medicine and Oxford Particle Imaging Centre of Oxford University, UK from 2014-2015. He rose to a Research Associate Professor (2018) and Research Professor (IBP Fellow, Principal Investigator, 2019) in Institute of Biophysics, Chinese Academy of Sciences. He joined ShanghaiTech University in 2020 as an Assistant Professor of School of Life Science and Technology and a Principal Investigator of Shanghai Institute for Advanced Immunochemical Studies (SIAIS).
------------------------------------------------------------------------------------------------------------------ Research Interests
Dr. Wang committed to studying the molecular composition, structural characteristics and functional mechanisms of the energy metabolism system of pathogenic microorganisms such as Mycobacterium tuberculosis and Helicobacter pylori at multiple scales by using cryo-electron microscopy and other imaging techniques. In addition, through interfering biological energy metabolism system, we carry out drug screening and development to fight the drug-resistant pathogens and tumors.
------------------------------------------------------------------------------------------------------------------ Publications Structural Biology Wang Q*, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P*, Rao Z* (2020). Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell. doi: https://doi.org/10.1016/j.cell.2020.05.034. [Representative Publication, Co-first Author] Lu Zhang#; Yao Zhao#; Yan Gao; Lijie Wu; Ruogu Gao; Qi Zhang; Yinan Wang; Chengyao Wu; Fangyu Wu; Sudagar S. Gurcha; Natacha Veerapen; Sarah M. Batt; Wei Zhao; Ling Qin; Xiuna Yang; Manfu Wang; Yan Zhu; Bing Zhang; Lijun Bi; Xian’en Zhang; Haitao Yang; Luke W. Guddat; Wenqing Xu; Quan Wang*; Jun Li*; Gurdyal S. Besra*; Zihe Rao*, Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol, Science, eaba9102 (2020) doi:10.1126/science.aba9102. [Representative Publication, Co-corresponding Author] Yan Gao#; Liming Yan1#; Yucen Huang#; Fengjiang Liu#; Yao Zhao; Lin Cao; Tao Wang; Qianqian Sun; Zhenhua Ming; Lianqi Zhang; Ji Ge; Litao Zheng; Ying Zhang; Haofeng Wang; Yan Zhu; Chen Zhu; Tianyu Hu; Tian Hua; Bing Zhang; Xiuna Yang; Jun Li; Haitao Yang; Zhijie Liu; Wenqing Xu; Luke W. Guddat; Quan Wang*; Zhiyong Lou*; Zihe Rao*, Structure of the RNA-dependent RNA polymerase from COVID-19 virus, Science, eabb7498 (2020) doi:10.1126/science.abb7498. [Representative Publication, Co-corresponding Author] Hongri Gong#; Jun Li#; Ao Xu#; Yanting Tang; Wenxin Ji; Ruogu Gao; Shuhui Wang; Lu Yu; Changlin Tian; Jingwen Li; Hsin Yung Yen; Sin Man Lam; Guanghou Shui; Xiuna Yang; Yuna Sun; Xuemei Li; Minze Jia; Cheng Yang; Biao Jiang; Zhiyong Lou; Carol V Robinson; Luet Lok Wong; Luke W Guddat; Fei Sun*; Quan Wang*; Zihe Rao*, An electron transfer path connects subunits of a mycobacterial respiratory supercomplex , Science, 2018.10.25, 362(6418): 0~eaat8923 [Representative Publication, Co-corresponding Author] Wenxia Liu#; Aijun Liu; Hailong Gao; Quan Wang; Limin Wang; Eberhard Warkentin; Zihe Rao; Hartmut Michel*; Guohong Peng*, Structural properties of the peroxiredoxin AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus, Biochimica et Biophysica Acta-General Subjects, 2018.12, 1862(12): 2797~2805 Kotecha Abhay#; Wang Quan; Dong Xianchi; Ilca Serban L; Ondiviela Marina; Zihe Rao; Seago Julian; Charleston Bryan; Fry Elizabeth E; Abrescia Nicola G A; Springer Timothy A*; Huiskonen Juha T*; Stuart David I*, Rules of engagement between alpha v beta 6 integrin and foot-and-mouth disease virus, Nature Communications, 2017.05.23, 8: 0~15408 Dang, Minghao#; Wang, Xiangxi; Wang, Quan; Wang, Yaxin; Lin, Jianping; Sun, Yuna; Li, Xuemei; Zhang, Liguo; Lou, Zhiyong; Wang, Junzhi; Rao, Zihe*, Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71., Protein & Cell, 2014.9, 5(9): 692~703 Li, Baobin#; Wang, Quan#; Pan, Xijiang; Fernandez de Castro, Isabel; Sun, Yuna; Guo, Yu; Tao, Xinwei; Risco, Cristina; Sui, Sen-Fang; Lou, Zhiyong*, Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation., Proceedings of the National Academy of Sciences of the United States of America, 2013.05.28, 110(22): 9048~9053 [Representative Publication, Co-first Author] Chen, Qingfeng#; Chen, Xiangsong#; Wang, Quan; Zhang, Faben; Lou, Zhiyong*; Zhang, Qifa*; Zhou, Dao-Xiu*, Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice., PLoS Genetics, 2013, 9(1) Chen, Qingfeng#; Wang, Quan; Xiong, Lizhong*; Lou, Zhiyong*, A structural view of the conserved domain of rice stress-responsive NAC1., Prot ein Cell, 2011.1, 2(1): 55~63 Wang, Hui#; Morita, Masahiro; Yang, Xiuna; Suzuki, Toru; Yang, Wen; Wang, Jiao; Ito, Kentaro; Wang, Quan; Zhao, Cong; Bartlam, Mark*; Yamamoto, Tadashi*; Rao, Zihe, Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity., The EMBO Journal, 2010.8.4, 29 (15): 2566~2576 Drug Discovery Dong, Jing#; Zhang, Yong; Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Yang, Cheng; Wang, Quan; Li, Xuemei*; Deng, Xuming*, Baicalin inhibits the lethality of Shiga-like toxin 2 in mice., Antimicrobial Agents and Chemotherapy, 2015.11, 59(11): 7054~7060 Cao, Shujuan#; Yu, Liang; Mao, Jingyuan; Wang, Quan; Ruan, Jishou*, Uncovering the Molecular Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network., PLos One, 2015, 10(12) Shanshan Qin#; Yiran Ren#; Xu Fu; Jie Shen; Xin Chen; Quan Wang; Xin Bi; Wenjing Liu; Lixin Li; Guangxin Liang; Cheng Yang; Wenqing Shui*, Multiple ligand detection and affinity measurement by ultrafiltration and mass spectrometry analysis applied to fragment mixture screening, Analytica Chimica Acta, 2015.7.30, 886: 98~106 Chen, Xin#; Qin, Shanshan; Chen, Shuai; Li, Jinlong; Li, Lixin; Wang, Zhongling; Wang, Quan; Lin, Jianping; Yang, Cheng; Shui, Wenqing*, A ligand-observed mass spectrometry approach integrated into the fragment-based lead discovery pipeline., Scientific Reports, 2015, 5: 8361~8361 Dong, Jing#; Zhang, Yong; Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Li, Rui; Yang, Cheng; Wang, Quan; Li, Xuemei; Deng, Xuming*, Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization., Journal of Biological Chemistry, 2015.5.15, 290(20): 12899~12907 Dazhi Liu#; Zhen Tian; Zhihui Yan; Lixin Wu; Yan Ma; Quan Wang; Wei Liu*; Honggang Zhou; Cheng Yang, Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors, Bioorganic & Medicinal Chemistry, 2013.6.1, 21(11): 2960~2967
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