Selected Publication List: (*Co-first author, #Correspondent author)

1.      Xiang J*, Su J*, Lan Q*, Zhao W, Zhou Y, Xu Y, Niu J, Xia S, Qi Q, Sidhu S, Lu L#, Miersch S#Yang B#. (2022) Antigenic mapping reveals sites of vulnerability on α-HCoV spike protein. Communications Biology, 5(1):1179

2.      Jia X*, Li Y*, Wang T, Bi L, Guo L, Chen Z, Zhang X, Ye S, Chen J, Yang B, Sun B. (2022) Discrete RNA-DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate-limiting steps. The EMBO Journal, 3:e111703

3.      Li X*, Zhou L*, Gao BQ*, Li G, Wang X, Wang Y, Wei J, Han W, Wang Z, Li J, Gao R, Zhu J, Xu W, Wu J, Yang B, Sun X#, Yang L#, Chen J#. (2022) Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure. Nature Communications, 13(1):1669

4.      Wang LJ*, Xue W*, Zhang HX*, Gao RZ*, Qiu HY*, Wei J, Zhou LN, Lei YN, Wu XC, Li X, Liu CF, Wu J, Chen QB, Ma HH, Huang XX, Cai C, Zhang Y, Yang B#, Yin H#, Yang L#, Chen J#. (2021) Eliminating genome-wide and transcriptome-wide off-target mutations by base editor. Nature Cell Biology, 23:552-563

5.      Shi X*, Wan Y*, Wang N*, Xiang J*, Wang T, Yang X, Wang J, Dong X, Dong L, Yan L, Li Y, Liu L, Hou S, Zhong Z, Wilson IA, Yang B, Yang G#, Lerner RA#. (2021) Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms. Nature Communications, 12(1):2547

6.      Meng B, Lan KK, Xie J, Lerner RA, Wilson IA#Yang B#. (2020) Inhibitory antibodies identify novel sites of therapeutic vulnerability in rhinovirus and other Enteroviruses. Proceedings of the National Academy of Sciences, 117 (24): 13499-13508

7.      Wang X*, Ding C*, Yu W*, Wang Y*, He S*, Yang B*, Xiong YC, Wei J, Li J, Liang J, Lu Z, Zhu W, Wu J, Zhou Z, Huang X, Liu Z#, Yang L#, Chen J#. (2020) Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response. Cell Report, 31(9):107723 

8.      Cui YR*, Wang SJ*, Chen J, Li J, Chen W, Wang S, Meng B, Zhu W, Zhang Z, Yang B, Jiang B, Yang G, Ma P#., Liu J#. (2020) Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides. Genome Biology, 21(1):51

9.      Xu JC*, Cui KJ*, Shen LQ, Shi J, Li LT, You LL, Fang CL, Zhao GP#, Feng Y#Yang B#, Zhang Y#. (2019) Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor. eLife, 8: e50928

10.   Yang L#Yang B#, Chen J#. (2019) One Prime for All Editing. Cell, 179(7):1448-1450

11.   Chen J#Yang B#, Yang L#. (2019) To BE or not to BE, that is the question. Nature Biotechnology, 37(5):520-522

12.   Yang B#, Yang L# and Chen J#(2019) Development and Application of Base Editors. The CRISPR Journal, 2: 91-104

13.   Zhao Q*, Ren C*, Liu L, Chen J, Shao Y, Sun N, Sun R, Kong Y, Ding X, Zhang X, Xu Y, Yang B, Yin Q#, Yang X#, Jiang B#. (2019) Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. Journal of Medicinal Chemistry, 62(20):9281-9298

14.   Wang Y*, Gao R*, Wu J, Xiong YC, Wei J, Zhang S, Yang B, Chen J#, Yang L#. (2019) Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs. Genome Biology, 20(1):218

15.   Xia S, Yan L, Xu W, Agrawal AS, Algaissi A, Tseng CK, Wang Q, Du L, Tan W, Wilson IA#, Jiang S#Yang B#, Lu L#. (2019) A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Science Advances, 5(4): eaav4580

16.   Yan L, Meng B, Xiang J, Wilson IA# & Yang B#. (2018) Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolution. Acta Crystallographica Section D, 74(Pt 9):841-851 

17.   Wang X*, Li J*, Wang Y*, Yang B*, Wei J, Wu J, Wang R, Huang X#, Chen J#, Yang L#. (2018) Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion. Nature Biotechnology, 36(10):946-949  

18.   Qiang M, Dong X, Zha Z, Zuo XK, Song XL, Zhao LX, Yuan C, Huang C, Tao PD, Hu Q, Li WG, Hu WH, Li J, Nie Y, Buratto D, Zonta F, Ma PX, Yu Z, Liu LL, Zhang Y, Yang B, Xie J, Xu TL, Qu ZH#, Yang G#, Lerner RA#. (2018) Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death. Proceedings of the National Academy of Sciences, 115(32): E7469-E7477

19.   Li X*, Wang Y*, Liu Y*, Yang B*, Wang X, Wei J, Lu Z, Zhang Y, Wu J, Huang X#, Yang L#, Chen J#. (2018) Base editing with a Cpf1-cytidine deaminase fusion. Nature Biotechnology, 36(4):324-327

20.   Lei L*, Chen H*, Xue W*, Yang B*, Hu B*, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Gao J, Sha J, Zhuang M, Huang X, Shen B#, Yang L#, Chen J#. (2018) APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks. Nature Structural & Molecular Biology, 25(1):45-52

21.   Yang B#, Li X, Lei L, Chen J#. (2017) APOBEC: From mutator to editor. Journal of Genetics and Genomics, 44(9):423-437

22.   Wang L*, Xue W*, Yan L*, Li X, Wei J, Chen M, Wu J, Yang B#, Yang L#, Chen J#. (2017) Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor. Cell Research, 27(10):1289-1292