Selected Publication List: (*Co-first author, #Correspondent author)


Niu J*, Wang Q*, Zhao W*, Meng B*, Xu Y*, Zhang X, Feng Y, Qi Q, Hao Y, Zhang X, Liu Y, Xiang J, Shao Y# Yang B#. (2023) Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs. Nature Communications, 14(1):4676.

Zhao W*, Li J*, Wang X*, Xu W*, Gao BQ*, Xiang J, Hou Y, Liu W, Wu J, Qi Q, Wei J, Yang X, Lu L#, Yang L#, Chen J#Yang B#. (2023) Prime editor-mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS-CoV-2 variants. MedComm4:e356.

Han W, Qiu H, Sun S, Fu Z, Wang G, Qian X, Wang L, Zhai X, Wei J, Wang Y, Guo Y, Cao G, Ji R, Zhang Y, Ma H, Wang H, Zhao M, Wu J, Bi Li, Chen Q, Li Z, Yu L, Mou X, Yin H, Yang L#, Chen J#, Yang B#, Zhang Y#. (2023) Therapeutic base editing of HBG promoter to reactivate high level of γ-globin expression with no detectable off-target mutations. Cell Stem Cell, 30:1–16

 Sun S, Zhu R, Zhu M, Wang Q, Li N#, Yang B#.(2023) Visualization of conformational transition of GRP94 in solution. Life Science Alliance, 7(2):e202302051

Xiang J*, Su J*, Lan Q*, Zhao W, Zhou Y, Xu Y, Niu J, Xia S, Qi Q, Sidhu S, Lu L#, Miersch S#Yang B#. (2022) Antigenic mapping reveals sites of vulnerability on α-HCoV spike protein. Communications Biology, 5(1):1179

Jia X*, Li Y*, Wang T, Bi L, Guo L, Chen Z, Zhang X, Ye S, Chen J, Yang B, Sun B. (2022) Discrete RNA-DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate-limiting steps. EMBO Journal, 3:e111703

Li X*, Zhou L*, Gao BQ*, Li G, Wang X, Wang Y, Wei J, Han W, Wang Z, Li J, Gao R, Zhu J, Xu W, Wu J, Yang B, Sun X#, Yang L#, Chen J#. (2022) Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure. Nature Communications, 13(1):1669


Wang LJ*, Xue W*, Zhang HX*, Gao RZ*, Qiu HY*, Wei J, Zhou LN, Lei YN, Wu XC, Li X, Liu CF, Wu J, Chen QB, Ma HH, Huang XX, Cai C, Zhang Y, Yang B#, Yin H#, Yang L#, Chen J#. (2021) Eliminating genome-wide and transcriptome-wide off-target mutations by base editor. Nature Cell Biology, 23:552-563

Shi X*, Wan Y*, Wang N*, Xiang J*, Wang T, Yang X, Wang J, Dong X, Dong L, Yan L, Li Y, Liu L, Hou S, Zhong Z, Wilson IA, Yang B, Yang G#, Lerner RA#. (2021) Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms. Nature Communications, 12(1):2547

Meng B, Lan KK, Xie J, Lerner RA, Wilson IA#Yang B#. (2020) Inhibitory antibodies identify novel sites of therapeutic vulnerability in rhinovirus and other Enteroviruses. Proceedings of the National Academy of Sciences, 117 (24): 13499-13508

Wang X*, Ding C*, Yu W*, Wang Y*, He S*, Yang B*, Xiong YC, Wei J, Li J, Liang J, Lu Z, Zhu W, Wu J, Zhou Z, Huang X, Liu Z#, Yang L#, Chen J#. (2020) Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response. Cell Report, 31(9):107723 

Cui YR*, Wang SJ*, Chen J, Li J, Chen W, Wang S, Meng B, Zhu W, Zhang Z, Yang B, Jiang B, Yang G, Ma P#., Liu J#. (2020) Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides. Genome Biology, 21(1):51


Xu JC*, Cui KJ*, Shen LQ, Shi J, Li LT, You LL, Fang CL, Zhao GP#, Feng Y#Yang B#, Zhang Y#. (2019) Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor. eLife, 8: e50928

Xia S, Yan L, Xu W, Agrawal AS, Algaissi A, Tseng CK, Wang Q, Du L, Tan W, Wilson IA#, Jiang S#Yang B#, Lu L#. (2019) A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Science Advances, 5(4): eaav4580

Yang L#Yang B#, Chen J#. (2019) One Prime for All Editing. Cell, 179(7):1448-1450

Chen J#Yang B#, Yang L#. (2019) To BE or not to BE, that is the question. Nature Biotechnology, 37(5):520-522

Yang B#, Yang L# and Chen J#(2019) Development and Application of Base Editors. The CRISPR Journal, 2: 91-104

Zhao Q*, Ren C*, Liu L, Chen J, Shao Y, Sun N, Sun R, Kong Y, Ding X, Zhang X, Xu Y, Yang B, Yin Q#, Yang X#, Jiang B#. (2019) Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. Journal of Medicinal Chemistry, 62(20):9281-9298

Wang Y*, Gao R*, Wu J, Xiong YC, Wei J, Zhang S, Yang B, Chen J#, Yang L#. (2019) Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs. Genome Biology, 20(1):218

Yan L, Meng B, Xiang J, Wilson IA# & Yang B#. (2018) Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolution. Acta Crystallographica Section D, 74(Pt 9):841-851 

Wang X*, Li J*, Wang Y*, Yang B*, Wei J, Wu J, Wang R, Huang X#, Chen J#, Yang L#. (2018) Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion. Nature Biotechnology, 36(10):946-949  

Qiang M, Dong X, Zha Z, Zuo XK, Song XL, Zhao LX, Yuan C, Huang C, Tao PD, Hu Q, Li WG, Hu WH, Li J, Nie Y, Buratto D, Zonta F, Ma PX, Yu Z, Liu LL, Zhang Y, Yang B, Xie J, Xu TL, Qu ZH#, Yang G#, Lerner RA#. (2018) Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death. Proceedings of the National Academy of Sciences, 115(32): E7469-E7477

Li X*, Wang Y*, Liu Y*, Yang B*, Wang X, Wei J, Lu Z, Zhang Y, Wu J, Huang X#, Yang L#, Chen J#. (2018) Base editing with a Cpf1-cytidine deaminase fusion. Nature Biotechnology, 36(4):324-327

Lei L*, Chen H*, Xue W*, Yang B*, Hu B*, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Gao J, Sha J, Zhuang M, Huang X, Shen B#, Yang L#, Chen J#. (2018) APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks. Nature Structural & Molecular Biology, 25(1):45-52


  Wang L*, Xue W*, Yan L*, Li X, Wei J, Chen M, Wu J, Yang B#, Yang L#, Chen J#. (2017) Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor. Cell Research, 27(10):1289-1292

  Yang B#, Li X, Lei L, Chen J#. (2017) APOBEC: From mutator to editor. Journal of Genetics and Genomics, 44(9):423-437