石硕 博士
Research Assistant Professor

Address: Rm B506, Ren Building, 393 Middle Huaxia Road, Pudong, Shanghai, China

Phone: 0086-13020120165

Email: shishuo@@shanghaitech.edu.cn
Citizenship/Residency:

Guangdong Province, P.R.China

Languages:

Fluent in both spoken and written English and Chinese (Cantonese and Mandarin)

Education:

Ph.D. in Molecular Biology and Biochemistry

Key Laboratory of Oncology
Institute for Nutritional Sciences 09/2005 –01/2012
SIBS, Chinese Academy of Sciences Shanghai, China

B.S. in Biotechnology

College of Life Science 09/2000 – 07/2004
Huazhong University of Science and Technology Wuhan, China


Working Experiences:

Research Assistant Professor
Key Laboratory of Stem Cell
Shanghai Institute for Advanced Immunochemical Studies (SIAIS)                        
ShanghaiTech University Shanghai, China                                                                07/2017-Now

Senior Post-doctoral Fellow in Cancer and Stem Cell Research
Key Laboratory of Stem Cell
Shanghai Institute for Advanced Immunochemical Studies (SIAIS)                  
ShanghaiTech University Shanghai, China                                                          07/2014-07/2017

Post-doctoral Fellow in Stem Cell Research
Key Laboratory of Stem Cell and Regenerative Medicine
School of Biomedical Sciences                                    

Chinese University of Hong Kong,Hong Kong, China                                      02/2013-06/2014

Publications:

 (Corresponding author; * Contributed equally)

1. Wang HMHuang RLi NZhu JJLi ZHPeng CZhuang XRLin HFShi S#Huang PY#,“CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini” Cell Discover.  2021 Apr 19;7(1):25. doi: 10.1038/s41421-021-00265-2

2. Shi S, Yang ZZ, Liu SH, Yang F, Lin H, “PIWIL1 Promotes Gastric Cancer via a piRNA-Independent Mechanism” Proc Natl Acad Sci U S A. 2020 Aug 26; 202008724. doi: 10.1073/pnas.2008724117

3. Zhao JS, Shi S, Qu HY, Keckesova Z, Cao ZJ, Yang LX, Yu XF,      Feng LM, Shi Z, Xu DQ, Gao XF, You J, Li WB, Liang TB, Lu ZM, Feng XY, “Glutamine synthetase licenses APC/C-mediated mitotic progression to drive tumour growth” Nat Metab. 2022 Feb;4(2):239-253. doi:10.1038/s42255-021-00524-2. Epub 2022 Feb 10.

4. Wang C, Yang ZZ, Guo FH, Shi S, Han XS,  Zeng A, Lin H, Jing Q, “Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea” J Biol Chem. 2019 Jun 21;294(25):9873-9887. PMID: 31076507

5. Ma H, Zhao BL, Liu BY, Shi S, Gao DY, Zhang TC, Shi HJ, Li Z, Shum WW, Vitamin K2-Dependent GGCX and MGP are required for Homeostatic Calcium Regulation of Sperm MaturationiScience 2019 Apr 26; 14:210-225. PMID: 30981116

6. Liu S, Wang Z, Liu Z, Shi S, Zhang Z, Zhang J, Lin H, “miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer” J Mol Cell Biol. 2018 Aug 1;10(4):302-315. PMID: 30053090

7. Deng YZ, Cai Z, Shi S, Jiang H,  Shang YRMa NWang JJGuan DXChen TWRong YFQian ZYZhang EBFeng DZhou QLDu YNLiu DPHuang XXLiu LMChin ELi DSWang XFZhang XLXie D, “cilia loss sensitizes cells to transformation by activating the mevalonate pathway” J Exp Med. 2018 Jan 2;215(1):177-195. PMID: 29237705

8. Zhang BL, Gao DY, Zhang XX, Shi S, Shum WW, “whole-cell Patch-clamp Recordings of Isolated Primary Epithelial Cells from the Epididymis” J Vis Exp. 2017; (126): 55700. PMID: 28809845

9Wang ZF, Liu N, Shi S, Liu S, Lin H, “The role of PIWIL4, an Argonaute Family Protein, in Breast Cancer” J Biol Chem. 2016 May 13;291(20):10646-58. 2016 Mar 8. PMID: 26957540

10. Tsang WH*, Wang B*, Wong WK*, Shi  S*, Chen X, He XJ, Gu  S, Hu JB, Wang CD, Liu PC, Lu G, Chen XF, Zhao H, Poon WS, Chan WY, Feng B, “Lif-dependent primitive neural stem cells derived from mouse ES cells represent a reversible stage of neural commitment” Stem Cell Research 2013 Jul 26. (*co-first authors). PMID: 23973799
11. 
Shi S, Deng YZ, Zhao JS, Ji XD, Shi J, Feng YX, Li G, Li JJ, Zhu D, Koeffler HP, Zhao Y, Xie D, “RACK1 Promotes Non-small-cell Lung Cancer Tumorigenicity through activating Sonic Hedgehog Signaling Pathway” J Biol Chem. 2012 Mar 9;287(11):7845-58. 2012 Jan 19. PMID: 22262830
12. Zhu D, 
Shi S, Wang H, Liao K, “Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes” Journal of Cell Science 2009 Aug 1;122(Pt 15):2760-8. PMID: 19596798
13. Ji XD, Li G, Feng YX, Zhao JS, Li JJ, Sun ZJ, 
Shi S, Deng YZ, Xu JF, Zhu YQ, Koeffler HP, Tong XJ, Xie D, “EphB3 Is Overexpressed in Non–Small-Cell Lung Cancer and Promotes Tumor Metastasis by Enhancing Cell Survival and Migration” Cancer Res; 71(3); 1156–66.  PMID: 21266352
14. Li G , Ji XD, Zhao JS, 
Shi S, Feng YX, Li JJ, Xie D, “EphB3 mediates kinase-dependent suppression of non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signaling complex” Nature commun. 2012 Feb 7;3:667. PMID: 22314363
15. Deng YZ, Fan Yao, Hu PT, Long LY, 
Shi S, Ji XD, Li G, Li JJ, Yong Liu, Xie D, “RACK1(Receptor for Activated PKC) suppresses gastric cancer tumorigenesis through negatively regulating Wnt/β-catenin signaling” Gastroenterology 2012 Jan 10. PMID: 22240482
16. Hayano T, Garg M, Yin D, Sudo M, Kawamata N,
 Shi S, Chien W, Ding LW, Leong G, Mori S, Xie D, Tan P, Koeffler HP, “SOX7 is down-regulated in lung cancer” J Exp Clin Cancer Res. 2013 Apr 4;32:17.PMID: 23557216
17.
Sun QY, Ding LW, Xiao JF, Chien WW, Lim SL, Hattori N, Goodglick L, Chia D, Mah V, Alavi M, Kim SR, Doan N, Said JWLoh XYXu LLiu LZHenry YHayano T, Shi S, Xie D, Lin DC, Koeffler HP, “SETDB1 accelerates tumorigenesis by regulating Wnt signaling pathway.”J Pathol. 2015 Mar; 235(4): 559–570. PMID: 25404354


Patents:

        PCT Patent

Title: Compositions and methods for treating cancer by inhibiting PIWIL4

Applicant: Haifan Lin, Zifeng Wang, Sanhong Liu, Shuo Shi

Applicant No.: 16/469,816

Chinese Patent/ PCT Patent

Title: PIWI /NMD 复合体蛋白在高表达PIWI 的癌症中的诊断与治疗

Applicant: Haifan Lin, Shuo Shi, Zhenzhen Yang

Applicant No.:202010359757.5/202110468466.4