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Laboratories

  • Lab of Antibody Design
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  • Lab of Antibody Chemistry
  • Lab of Phenotypic Screening
  • Lab of Structure Biochemistry
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  • Publications

1. Zhang H., Du M., Xie J., Liu X., Sun J., Wang W., Xin X., Possani L.D., Yea K., and Lerner R.A. (2016) Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries. Angew Chem Int Ed Engl doi: 10.1002/anie.201603052.


1. K Yea, Zhang H K, Xie J, Jones T M, Lin C W, Francesconi W, Berton F, Fallahi M, Sauer K and Lerner R A. Agonist antibody that induces human malignant cells to kill one another. Proceedings of the National Academy of Sciences of the United States of America 112, E6158-E6165, doi:10.1073/pnas.1519079112 (2015).


2. Yea K, Xie J, Zhang H, Zhang W, Lerner RA. ”Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic.” Curr Opin Chem Biol. 2015 Jan 23;26C:1-7. doi: 10.1016/j.cbpa.2015.01.002. [Epub ahead of print] Review.


3. Xie J, Yea K, Zhang H, Moldt B, He L, Zhu J, Lerner RA. ”Prevention of cell death by antibodies selected from intracellular combinatorial libraries.” Chem Biol. 2014 Feb 20;21(2):274-83. doi: 10.1016/j.chembiol.2013.12.006. Epub 2014 Jan 16.


4. Yea K, Zhang H, Xie J, Jones TM, Yang G, Song BD, Lerner RA. “Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections.” Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14966-71. doi: 10.1073/pnas.1313671110. Epub 2013 Aug 26.










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