​On July 7, a research team led by Research Associate Professor Zhang Heqiao and Distinguished Adjunct Professor Roger Kornberg (Lab of Structural Biochemistry) at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, published a research article in Cell. The study, titled “Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition,” elucidates the molecular mechanism by which non-nucleoside inhibitors suppress

On December 11, the Laboratory of Structural Biochemistry at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao, published a research article in Science Advances titled “Cryo-EM Structure of Nipah Virus RNA Polymerase Complex.” This study provides a detailed characterization of the structural features of the Nipah virus polymerase complex.

​Recently, the Laboratory of Structural Biochemistry at SIAIS, led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao, published a research article entitled “Class I histone deacetylase complex: structure and functional correlates” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a 3.2 Å resolution cryo-EM structure of the class I histone deacetylase (HDAC) complex.

​Recently, a group led by Distinguished Adjunct Professor Roger Kornberg and Research Associate Professor Zhang Heqiao of the laboratory of structure biochemistry at SIAIS, published a paper entitled “Structure of the NuA4 histone acetyltransferase complex” in the Proceedings of the National Academy of the Sciences (PNAS), reporting a near-atomic resolution structure of the NuA4 complex in eukaryotes obtained by cryo-electron microscopy (cryo-EM).